Postmarketing pharmacokinetic and pharmacodynamic equivalence of generic and brand atenolol in Egypt.

Concerns have been raised regarding the postmarketing quality of generic drugs. This study assessed the pharmacokinetic and pharmacodynamic equivalence of generic and brand atenolol tablets in 24 healthy male volunteers in a single-dose, open, randomized, two-period crossover study under fasting conditions. Blood samples were collected for 24 h post dosing and assayed for atenolol using HPLC. Blood pressure and heart rate were measured at baseline and throughout blood sampling. The mean plasma concentration-time curves for both products were similar. Pharmacokinetic and statistical analysis indicated bioequivalence based on the mean ratios of log-transformed Cmax and AUC values. Both products had similar time courses of pharmacodynamic activity with a significant fall in blood pressure and heart rate (maximum after ~5 h) followed by a gradual increase towards baseline. Both products were well tolerated. Both atenolol products were bioequivalent in the postmarketing setting and can be used interchangeably in clinical practice.

Postmarketing pharmacokinetic and pharmacodynamic equivalence of generic and brand atenolol in Egypt

Concerns have raised regarding the postmarketing quality of generic drugs. This study assessed the pharmacokinetic and pharmacodynamic equivalence of generic and brand atenolol tablets in 24 healthy male volunteers in a single-dose, open, randomized, two-period crossover study under fasting conditions. Blood samples were collected for 24 h post dosing and assayed for atenolol using HPLC. Blood pressure and heart rate were measured at baseline and throughout blood sampling. The mean plasma concentration-time curves for both products were similar. Pharmacokinetic and statistical analysis indicated bioequivalence based on the mean ratios of log-transformed Cmax and AUC values. Both products had similar time courses of pharmacodynamic activity with a significant fall in blood pressure and heart rate [maximum after ~5 h] followed by a gradual increase towards baseline. Both products were well tolerated. Both atenolol products were bioequivalent in the postmarketing setting and can be used interchangeably in clinical practice

Psychometric properties of the pressure to move scale in relocated american older adults: further evaluation.

The number of elders who relocate to retirement communities is increasing exponentially, and their ability to exercise free choice, personal control, and autonomy has been associated with relocation adjustment and positive outcomes in regard to physical, emotional, and social well-being. Although a measure of relocation controllability (the degree of personal control associated with the move) exists, there is limited evidence of its psychometric adequacy. This study tested the reliability and validity of the Pressure to Move Scale (PTMS). A convenience sample of 104 American elders who relocated to six Northeast Ohio retirement communities was recruited. Study participants completed the nine-item PTMS and two validation measures during structured interviews. Cronbach's alpha was .71. Homogeneity was supported by item-to-total correlations between .30 and .70, except for two items. Deletion of the item asking about the elder's first impression of relocation improved the alpha to .74. The PTMS was correlated in the expected direction with positive cognitions (r = -.37, p < .01) and relocation adjustment (r = -.62, p < .01), indicating convergent validity. Factor extraction generated three factors, the first reflecting "internal" control factors and the second reflecting "external" control factors; a third factor, containing two items with low item-to-total correlations, reflected another level of "external" control. With preliminary evidence of its reliability and validity, this scale can be a useful tool for screening for pressure to move or involuntary relocation among older adults so that negative outcomes associated with relocation can be prevented through tailored interventions.

Reasons for relocation to retirement communities: a qualitative study.

The purpose of this qualitative study is to understand the reasons why elders move to retirement communities and what living in retirement communities is like from the perspective of relocated elders. Several themes emerged following qualitative analysis. The themes reflect three categories, labeled as "pushing" factors, "pulling" factors, and "overlapping" factors. Pushing factors included own or spouse's failing health, getting rid of responsibilities, not helped, facility closed out, and loneliness. Pulling factors were location, familiarity and reputation of the facility, security, and joining friends. The third category reflected both pushing and pulling factors, which overlapped and constituted their reason for moving. The findings help to inform the planning of tailored interventions to address elders' special needs or concerns associated with relocation.

Loneliness: a concept analysis.

TOPIC: Loneliness is a universal human experience recognized since the dawn of time, yet it is unique for every individual. Loneliness can lead to both depression and low self-esteem. PURPOSE: This article explicates the concept of loneliness through the examination of its conceptual definition and uses, defining attributes, related concepts, and empirical referents. SOURCES OF INFORMATION: Literature review using hand search and database were used as sources of information. CONCLUSION: Because loneliness is commonly encountered in nursing situations, the information provided will serve as a framework for assessment, planning, intervention, and evaluation of clients.

Happiness: theoretical and empirical considerations.

TOPIC: Although happiness is important in maintaining health, few studies of happiness can be found in the nursing literature. PURPOSE: This paper explicates the concept of happiness through examination of its defining attributes, antecedents, consequences, and measurement. SOURCES OF INFORMATION: Literature review using hand search, and databases were used as sources of information. CONCLUSION: The information provided can be used in clinical practice so that nursing strategies can be developed and tested to help people to become happy and healthy.