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3.
J Reprod Med ; 51(5): 399-404, 2006 May.
Article in English | MEDLINE | ID: mdl-16779987

ABSTRACT

OBJECTIVE: To assess the feasibility of applying postoperative objective criteria for preoperative evaluation of scheduled gynecologic cases. STUDY DESIGN: A preoperative evaluation program was introduced in which all surgeons were asked to voluntarily submit a 1-page case summary questionnaire for each elective gynecologic surgical procedure. A committee of departmental peers reviewed each submission for appropriateness of indications and completeness of preoperative evaluation. Cases were evaluated against quality assessment criteria sets created by the American College of Obstetricians and Gynecologists. Reviewed summaries were categorized as either meeting criteria, not meeting criteria but appropriate, not meeting criteria or no pertinent criteria available for the procedure planned. RESULTS: In all, 2,005 elective gynecologic surgical procedures were performed by 70 active surgeons during the 1-year study period; 1,166 procedures (58%) were reported. Of 70 surgeons, 57 reported at least 1 procedure, but only 6 were 100% compliant with their surgical submissions. In total, 1,008 procedures (86% of reported cases) met the criteria or were deemed appropriate by committee review. In 166 instances, additional information was requested from and provided by the surgeon before the case could be adjudicated. CONCLUSION: A voluntary program of preoperative surgical case review for scheduled gynecologic procedures appeared feasible but resulted in only modest initial participation.


Subject(s)
Gynecologic Surgical Procedures , Peer Review, Health Care , Preoperative Care/methods , Academic Medical Centers , Community-Institutional Relations , Feasibility Studies , Female , Guidelines as Topic , Gynecologic Surgical Procedures/methods , Humans , Quality Control
4.
Am J Med Genet A ; 131(2): 179-85, 2004 Dec 01.
Article in English | MEDLINE | ID: mdl-15523614

ABSTRACT

Ring chromosome 7 is a rare but well documented chromosomal aberration in man. So far at least 14 cases have been reported in the literature showing a variable but distinct pattern of phenotypic characteristics in affected individuals. Besides others, skin findings as pigmented naevi are especially frequent. Loss of chromosomal material from the terminal chromosome arms in the structurally abnormal ring chromosome 7 as well as somatic mosaicism with loss or gain of chromosome 7 has been suggested to be responsible for the clinical symptoms. We now report another case of a ring chromosome 7 in a 14-year-old boy with multiple remarkable congenital naevi, where we could demonstrate for the first time somatic mosaicism showing significant gain of chromosome 7 within a highly proliferating melanocytic congenital naevus (MCN).


Subject(s)
Chromosomes, Human, Pair 7 , Nevus, Pigmented/congenital , Nevus, Pigmented/genetics , Ring Chromosomes , Abnormalities, Multiple/genetics , Adolescent , Cytogenetic Analysis , Humans , In Situ Hybridization, Fluorescence , Lymphocytes , Male , Mosaicism
5.
Melanoma Res ; 14(4): 269-76, 2004 Aug.
Article in English | MEDLINE | ID: mdl-15305157

ABSTRACT

The purpose of the study was to evaluate whether signal-enhanced color Doppler sonography (CDS) is superior to native CDS in detection of characteristic vascularity patterns that are important for the differentiation between benign and malignant lymphadenopathy in patients with cutaneous melanomas. Twenty-two melanoma patients presenting with 24 structures suspicious for metastases in B-Mode sonography were examined using native and signal-enhanced CDS in a prospective two-center study. Presumptive sonographic diagnoses were compared with results of histopathological and follow-up examinations. Signal-enhanced CDS gave additional information about vascularization of lymph node metastases and reactive lymph nodes, which was indicative for the differential diagnosis in 12 of 24 examinations. For lymph node metastases, signal enhancement improved the visualization of accessory peripheral vessels in four of 10 examinations. Concerning reactive lymph nodes, hilar vessels in part with branching to the lymph node periphery could be better identified after application of the contrast enhancer in eight of 13 examinations. Signal-enhanced CDS is demonstrated as an important additional diagnostic tool for improved differentiation between malignant and reactive lymph nodes and may be of special value in preventing unnecessary lymphadenectomy in small reactive lymph nodes.


Subject(s)
Lymphatic Metastasis/diagnostic imaging , Melanoma/diagnostic imaging , Melanoma/pathology , Skin Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Female , Fibroadenoma/diagnostic imaging , Fibroadenoma/pathology , Follow-Up Studies , Humans , Inflammation/diagnostic imaging , Inflammation/pathology , Lymphatic Metastasis/pathology , Male , Melanoma/blood supply , Middle Aged , Skin Neoplasms/blood supply , Skin Neoplasms/diagnostic imaging , Ultrasonography, Doppler, Color
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