Analysing the contributions of lower limb muscles to eccentric cycling using musculoskeletal modeling and simulation.

Eccentric (ECC) cycling, compared to traditional concentric cycling, has been shown to improve muscle strength and neuromuscular control at a lower metabolic cost. Despite the popularity of this exercise in the sports and rehabilitation contexts, there is a gap in our knowledge of which muscles are behaving eccentrically during ECC cycling. To this end, we used a musculoskeletal model and computer simulations to calculate joint kinematics and muscle lengths during ECC cycling. Movements were recorded using 3D motion capture technology while cycling eccentrically on a custom-built semi-recumbent ergometer. The software Opensim was used to calculate joint kinematics and muscle lengths from recorded movements. We found that among the primary knee extensors, it was predominantly the Vastii muscles that acted eccentrically in the ECC cycling phase, with other lower limb muscles showing mixed eccentric/concentric activation. Additionally, the muscle force-length and force-velocity factors in the ECC phase suggest that changes to the participant's pose and pedaling speed may elicit larger active muscle forces. Our work provides an interesting application of musculoskeletal modeling to ECC cycling, and an alternative way to help understand in-vivo muscle mechanics during this activity.

Reliability and Variability of Lower Limb Muscle Activation as Indicators of Familiarity to Submaximal Eccentric Cycling.

Submaximal eccentric (ECC) cycling exercise is commonly used in research studies. No previous study has specified the required time naïve participants take to familiarize with submaximal ECC cycling. Therefore, we designed this study to determine whether critical indicators of cycling reliability and variability stabilize during 15 min of submaximal, semi-recumbent ECC cycling (ECC cycling). Twenty-two participants, aged between 18-51 years, volunteered to complete a single experimental session. Each participant completed three peak eccentric torque protocol (PETP) tests, nine countermovement jumps and 15 min of submaximal (i.e., 10% peak power output produced during the PETP tests) ECC cycling. Muscle activation patterns were recorded from six muscles (rectus femoris, RF; vastus lateralis, VL; vastus medialis, VM; soleus, SOL; medial gastrocnemius, GM; tibialis anterior, TA), during prescribed-intensity ECC cycling, using electromyography (EMG). Minute-to-minute changes in the reliability and variability of EMG patterns were examined using intra-class correlation coefficient (ICC) and variance ratios (VR). Differences between target and actual power output were also used as an indicator of familiarization. Activation patterns for 4/6 muscles (RF, VL, VM and GM) became more consistent over the session, the RF, VL and VM increasing from moderate (ICC = 0.5-0.75) to good (ICC = 0.75-0.9) reliability by the 11th minute of cycling and the GM good reliability from the 1st minute (ICC = 0.79, ICC range = 0.70-0.88). Low variability (VR ≤ 0.40) was maintained for VL, VM and GM from the 8th, 8th and 1st minutes, respectively. We also observed a significant decrease in the difference between actual and target power output (χ2 14 = 30.895, p = 0.006, W = 0.105), expressed primarily between the 2nd and 3rd minute of cycling (Z = -2.677, p = 0.007). Indicators of familiarization during ECC cycling, including deviations from target power output levels and the reliability and variability of muscle activation patterns stabilized within 15 min of cycling. Based upon this data, it would be reasonable for future studies to allocate ∼ 15 min to familiarize naïve participants with a submaximal ECC cycling protocol.

Use of planar covariation in lower limb kinematics to characterize adaptations of running after cycling in elite triathletes.

Purpose: To characterize alterations of lower limb intersegmental coordination during the acute phase of running after cycling among highly trained triathletes using an analysis of planar covariation. Methods: Nine highly trained triathletes completed a control run (CR) and a run after transitioning from cycling exercise (transition run, or TR condition) on a motorized treadmill at a self-selected pace. Sagittal plane kinematics were recorded using a 3D Vicon motion capture system. Intersegmental coordination of the thigh, shank and foot segments of the right lower limb and run loop planarity were calculated during running before cycling and at four different times after the end of cycling. Results: PCA showed a significant within-subject phase shift of the run loop planarity (F = 6.66, P = 0.01). Post hoc analysis showed significance median differences increase for u 3t parameter between CRSS vs. TR30 (P = 0.01), TRt1/2 (P = 0.01) and TRMRT (P = 0.01). No difference for u 3t parameter existed between CRSS vs. TRSS. Conclusion: Prior variable-cadence, moderate intensity cycling has a significant effect on run loop planarity and therefore intersegmental coordination during the acute transition phase among highly trained triathletes. However, alterations to lower limb coordination are corrected by the 3rd minute after the beginning of the post cycle run. We suggest that planar covariation can be used as a more sensitive measure of cycling-induced variations in running to characterize adaptation in elite and importantly, developing athletes.

Piloting a full-year, optics-based high school course on quantum computing.

Quantum computing was once regarded as a mere theoretical possibility, but recent advances in engineering and materials science have brought practical quantum computers closer to reality. Currently, representatives from industry, academia, and governments across the world are working to build the educational structures needed to produce the quantum workforce of the future. Less attention has been paid to growing quantum computing capacity at the high school level. This article details work at The University of Texas at Austin to develop and pilot the first full-year high school quantum computing class. Over the course of two years, researchers and practitioners involved with the project learned several pedagogical and practical lessons that can be helpful for quantum computing course design and implementation at the secondary level. In particular, we find that the use of classical optics provides a clear and accessible avenue for representing quantum states and gate operators and facilitates both learning and the transfer of knowledge to other Science, Technology, and Engineering (STEM) skills. Furthermore, students found that exploring quantum optical phenomena prior to the introduction of mathematical models helped in the understanding and mastery of the material.

A Semi-recumbent Eccentric Cycle Ergometer Instrumented to Isolate Lower Limb Muscle Contractions to the Appropriate Phase of the Pedal Cycle.

Eccentric (ECC) cycling is used in rehabilitation and sports conditioning settings. We present the construction and mode of operation of a custom-built semi-recumbent ECC cycle designed to limit the production of lower limb muscle activity to the phase of the pedal cycle known to produce ECC contractions. A commercially available semi-recumbent frame and seat (Monarch, 837E Semi-recumbent Bike, Sweden) were used to assemble the ergometer. An electrical drive train system was constructed using individual direct drive servo motors. To avoid active muscle activation occurring during the non-ECC pedaling phase of cycling, a "trip" mechanism was integrated into the drivetrain system using a servo-driven regenerative braking mechanism based on the monitoring of the voltage produced over and above a predetermined threshold produced by the motors. The servo drive internal (DC bus) voltage is recorded and internally monitored during opposing (OPP) and non-opposing (N-OPP) phases of the pedal cycle. To demonstrate that the cycle functions as desired and stops or "trips" when it is supposed to, we present average (of 5 trials) muscle activation patterns of the principal lower limb muscles for regular ECC pedal cycles in comparison with one pedal cycle during which the muscles activated outside the desired phase of the cycle for a sample participant. This semi-recumbent ECC cycle ergometer has the capacity to limit the occurrence of muscle contraction only to the ECC phase of cycling. It can be used to target that mode of muscle contraction more precisely in rehabilitation or training studies.

Reliability of a Protocol to Elicit Peak Measures Generated by the Lower Limb for Semi-recumbent Eccentric Cycling.

Semi-recumbent eccentric (ECC) cycling is increasingly used in studies of exercise with healthy and clinical populations. However, workloads are generally prescribed using measures obtained during regular concentric cycling. Therefore, the purpose of the study was to quantify the reliability of measures derived from a protocol that elicited peak ECC torque produced by the lower limb in a semi-recumbent position. Experiments were carried out on a dynamometer in a seated, semi-recumbent position identical to that of a custom-built ECC cycle, a modified Monark recumbent cycle. Thirty healthy participants completed two testing sessions. Each session comprised three series of six repetitions of a peak ECC torque protocol (PETP) on an isokinetic dynamometer. Absolute and relative reliability of peak torque, power, angle of peak torque, and work (recorded for each repetition) was determined using coefficient of variation (CV) and intraclass correlation coefficient (ICC), respectively. Ratings of perceived exertion (RPE), muscle soreness, and perceived effort (PE) were recorded pre-PETP, immediately post-PETP, and 1-min post each PETP. The protocol showed absolute reliability values <15% for mean peak (CV = 10.6-12.1) torque, power (CV = 10.4-12.3), angle of peak torque (CV = 1.2-1.4), and work (CV = 9.7-12.1). Moderate to high between-test relative reliability is reported for mean and highest torque (ICC = 0.84-0.95; ICC = 0.88-0.98), power (ICC = 0.84-0.94; ICC = 0.89-0.98), and work (ICC = 0.84-0.93; ICC = 0.88-0.98), respectively. Within-session peak torque, peak power, and peak work showed high relative reliability for mean (ICC = 0.92-0.95) and highest (ICC = 0.92-0.97) values. Overall, the PETP test provides a reliable way of determining peak ECC torque specific to semi-recumbent ECC cycling that may be used to prescribe workloads for this form of exercise.

Randomising stimulus intensity improves the variability and reliability of the assessment of corticospinal excitability.

BACKGROUND: Advances in the control of transcranial magnetic stimulation (TMS) have enabled greater randomisation of stimulus intensity. It is unclear if such randomisation improves assessments of corticospinal excitability. NEW METHOD: We recorded the amplitude of TMS-induced motor evoked potentials (MEPs) from the first dorsal interosseous muscle of eleven participants, during three TMS protocols: blocks of increasing intensity (IB), randomised blocks (RB) and inter-stimulus randomisation (IR). Stimulus intensities from 90 to 140% of active motor threshold described corticospinal input-output (I/O) properties. The experiment was repeated in five participants. RESULTS: Although MEP amplitudes did not differ between IB, RB and IR stimulation protocols, variability was lowest in the IR protocol, compared to IB and RB protocols. Reliability was highest in the IR protocol, compared to IB and IR protocols. COMPARISON WITH EXISTING METHODS: Randomising TMS intensity between each trial produces less variable and more reliable estimates of corticospinal excitability than previously used blocked protocols and produces the same I/O measures. CONCLUSIONS: Inter-trial randomization of TMS intensities appears to be the most reliable method for constructing I/O curves at multiple time points and decreases the variability of responses.

Global Corticospinal Excitability as Assessed in A Non-Exercised Upper Limb Muscle Compared Between Concentric and Eccentric Modes of Leg Cycling.

This study investigated the effects of eccentric (ECC) and concentric (CON) semi-recumbent leg cycling on global corticospinal excitability (CSE), assessed through the activity of a non-exercised hand muscle. Thirteen healthy male adults completed two 30-min bouts of moderate intensity ECC and CON recumbent cycling on separate days. Power output (POutput), heart rate (HR) and cadence were monitored during cycling. Global CSE was assessed using transcranial magnetic stimulation to elicit motor-evoked potentials (MEP) in the right first dorsal interosseous muscle before ('Pre'), interleaved (at 10 and 20 mins, t10 and t20, respectively), immediately after (post, P0), and 30-min post exercise (P30). Participants briefly stopped pedalling (no more than 60 s) while stimulation was applied at the t10 and t20 time-points of cycling. Mean POutput, and rate of perceived exertion (RPE) did not differ between ECC and CON cycling and HR was significantly lower during ECC cycling (P = 0.01). Group mean MEP amplitudes were not significantly different between ECC and CON cycling at P0, t10, t20, and P30 and CON (at P > 0.05). Individual participant ratios of POutput and MEP amplitude showed large variability across the two modes of cycling, as did changes in slope of stimulus-response curves. These results suggest that compared to 'Pre' values, group mean CSE is not significantly affected by low-moderate intensity leg cycling in both modes. However, POutput and CSE show wide inter-participant variability which has implications for individual neural responses to CON and ECC cycling and rates of adaptation to a novel (ECC) mode. The study of CSE should therefore be analysed for each participant individually in relation to relevant physiological variables and account for familiarisation to semi-recumbent ECC leg cycling.

The Rise of Elite Short-Course Triathlon Re-Emphasises the Necessity to Transition Efficiently from Cycling to Running.

Transitioning efficiently between cycling and running is considered an indication of overall performance, and as a result the cycle-run (C-R) transition is one of the most researched areas of triathlon. Previous studies have thoroughly investigated the impact of prior cycling on running performance. However, with the increasing number of short-course events and the inclusion of the mixed relay at the 2020 Tokyo Olympics, efficiently transitioning from cycle-run has been re-emphasised and with it, any potential limitations to running performance among elite triathletes. This short communication provides coaches and sports scientists a review of the literature detailing the negative effects of prior variable-cycling on running performance experienced among elite, short-course and Olympic distance triathletes; as well as discussing practical methods to minimise any negative impact of cycling on running performance. The current literature suggests that variable-cycling negatively effects running ability in at least some elite triathletes and that improving swimming performance, drafting during cycling and C-R training at race intensity could improve an athlete's triathlon running performance. It is recommended that future research clearly define the performance level, competitive format of the experimental population and use protocols that are specific to the experimental population in order to improve the training and practical application of the research findings.

Is Moderate Intensity Cycling Sufficient to Induce Cardiorespiratory and Biomechanical Modifications of Subsequent Running?

Walsh, JA, Dawber, JP, Lepers, R, Brown, M, and Stapley, PJ. Is moderate intensity cycling sufficient to induce cardiorespiratory and biomechanical modifications of subsequent running? J Strength Cond Res 31(4): 1078-1086, 2017-This study sought to determine whether prior moderate intensity cycling is sufficient to influence the cardiorespiratory and biomechanical responses during subsequent running. Cardiorespiratory and biomechanical variables measured after moderate intensity cycling were compared with control running at the same intensity. Eight highly trained, competitive triathletes completed 2 separate exercise tests; (a) a 10-minute control run (no prior cycling) and, (b) a 30-minute transition run (TR) (preceded by 20-minute of variable cadence cycling, i.e., run versus cycle-run). Respiratory, breathing frequency (fb), heart rate (HR), cost of running (Cr), rate constant, stride length, and stride frequency variables were recorded, normalized, and quantified at the mean response time (MRT), third minute, 10th minute (steady state), and overall for the control run (CR) and TR. Cost of running increased (p ≤ 0.05) at all respective times during the TR. The V[Combining Dot Above]E/V[Combining Dot Above]CO2 and respiratory exchange ratio (RER) were significantly (p < 0.01) elevated at the MRT and 10th minute of the TR. Furthermore, overall mean increases were recorded for Cr, V[Combining Dot Above]E, V[Combining Dot Above]E/V[Combining Dot Above]CO2, RER, fb (p < 0.01), and HR (p ≤ 0.05) during the TR. Rate constant values for oxygen uptake were significantly different between CR and TR (0.48 ± 0.04 vs. 0.89 ± 0.15; p < 0.01). Stride length decreased across all recorded points during the TR (p ≤ 0.05) and stride frequency increased at the MRT and 3 minutes (p < 0.01). The findings suggest that at moderate intensity, prior cycling influences the cardiorespiratory response during subsequent running. Furthermore, prior cycling seems to have a sustained effect on the Cr during subsequent running.

Neuromuscular and physiological variables evolve independently when running immediately after cycling.

During the early period of running after cycling, EMG patterns of the leg are modified in only some highly trained triathletes. The majority of studies have analysed muscle EMG patterns at arbitrary, predetermined time points. The purpose of this study was to examine changes to EMG patterns of the lower limb at physiologically determined times during the cycle-run transition period to better investigate neuromuscular adaptations. Six highly trained triathletes completed a 10 m in isolated run (IR), 30 min of rest, then a 20 min cycling procedure, before a 10 min transition run (C-R). Surface EMG activity of eight lower limb muscles was recorded, normalised and quantified at four time points. Oxygen uptake and heart rate values were also collected. Across all muscles, mean (± SD) EMG patterns, demonstrated significant levels of reproducibility for each participant at all four time points (α < 0.05; r = 0.52-0.97). Mean EMG patterns during C-R correlated highly with the IR patterns (α < 0.05). These results show that EMG patterns during subsequent running are not significantly affected by prior cycling. However, variability of muscle recruitment activity does appear to increase during C-R transition when compared to IR.