ABSTRACT
Palladium-catalyzed asymmetric intermolecular Mizoroki-Heck reaction for the construction of a chiral quaternary carbon center is developed, affording 2,2-disubstituted 2,5-dihydrofurans in high yield with excellent enantioselectivity. The products are easily converted into the corresponding butenolides with retention of enantioselectivity.
Subject(s)
Carbon/chemistry , Furans/chemical synthesis , Organometallic Compounds/chemistry , Palladium/chemistry , Catalysis , Furans/chemistry , Molecular Structure , StereoisomerismABSTRACT
A new strategy for the construction of a C=C-CF3 subunit has been developed via CuBr-catalyzed domino cyclization-trifluoromethylation of homopropargyl amines with Umemoto's reagent. 4-Trifluoromethyl-2,3-dihydro-pyrroliums were produced in high yields. The usefulness of these products has been demonstrated by the transformation of them into various other trifluoromethylated molecules.
Subject(s)
Amines/chemistry , Pyrroles/chemical synthesis , Amines/chemical synthesis , Bromides/chemistry , Catalysis , Copper/chemistry , Cyclization , Halogenation , Methylation , Pyrroles/chemistryABSTRACT
Pd-catalyzed asymmetric allylic alkylation of nitroalkanes and monosubstituted allylic substrates was performed to afford products with two adjacent chiral centers and with excellent regio-, diastereo-, and enantioselectivities. The usefulness of the protocol in organic synthesis was demonstrated by transformation of the product to an optically active homoallylamine, a 2,3-disubstituted tetrahydropyridine, and an α,ß-disubstituted amino acid derivative.