Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas.

Colorectal cancer is a common malignancy, and the incidence and mortality rates continue to rise. An important factor in the emergence of inflammation-induced colorectal carcinogenesis is elevated cyclooxygenase-2. Prostaglandin E2 (PGE2) over-production is frequently equated with cyclooxygenase-2 gene over-expression. PGE2 can be assessed by measuring the level of prostaglandin's main metabolite, PGE-M, in urine. Colorectal adenoma is a precancerous lesion that can lead to colorectal cancer. We conducted research to evaluate the association between urinary levels of the PGE-M and the risk of colorectal adenomas. In a western Chinese population, we identified 152 cases of adenoma and 152 controls patients without polyps. Adenoma cases were categorized into control, low-risk and high-risk groups. There was no significant change in PGE-M levels, between the control group and the low-risk adenoma group. In the high-risk group, the PGE-M levels were 23% higher than the control group. When compared to people with the lowest urine PGE-M levels (first quartile), people with greater urinary PGE-M levels had a higher chance of developing high-risk colorectal adenomas, with an adjusted odds ratio (95% CI) of 1.65 (0.76-3.57) in the fourth quartile group, (p= 0.013). We conclude urinary PGE-M is associated with the risk of developing high-risk adenomas. Urinary PGE-M level may be used as a non-invasive indicator for estimating cancer risk.

Lightweight Deep Learning Model for Marketing Strategy Optimization and Characteristic Analysis.

The business model of traditional market is declining day by day, and people's consumption cognition has risen to a new level with the leap in science and technology. Enterprises need to adjust and optimize their marketing strategies in time according to the new consumption characteristics, so as to smoothly adapt to the environmental changes in the Internet age. This paper briefly analyzes the relationship between sales development and psychology and constructs a fusion model that can predict preferences with the help of neural network structure of the deep learning method. Describe user portraits and characteristics, analyze users' purchasing behavior and credit literacy, and push related products combined with a hash algorithm to achieve accurate e-commerce marketing purposes. The results show that (1) the model constructed in this paper and five different models are used for multi-modal recognition analysis: the accuracy is 79.56%, the recall rate is 77.43%, F1 is 0.785, and the error value can be reduced to about 0.18 by epoch iteration; the model is superior and has great use value. (2) Using the model to extract user attribute features and predict certain preferences, 13 topics and weight ratios are obtained for users of a certain platform, and the portrait model of each user is constructed. (3) According to the portrait optimization, 8 different marketing strategies are obtained, and the marketing effect is remarkable, fluctuating between 69% and 82%, and the income situation is also satisfactory. The final model design is reasonable and the data performance is good, which provides an intelligent and efficient dynamic strategy service for enterprises.

Subsequently enhanced CPP to morphine following chronic but not acute footshock stress associated with corticosterone mechanism in rats.

The purpose of this study was to determine the morphine-induced place preference in rats pre-exposed to footshock stress and corticosterone (CORT). The authors also studied the involvement of dopamine mechanisms in the CORT-induced place preference. The results showed that chronic footshock or CORT exposure but not acute footshock or CORT exposure similarly potentiated the conditioned place preference to morphine. The CORT-induced conditioned place preference were established only with high and middle dose (5, 3 mg/kg) CORT. The dopamine levels in NAc of rats injected with CORT (5, 3, 1 mg/kg, i.p.) increased significantly. The findings suggest that the increase of dopamine levels in NAc induced by CORT might be the medium between stress and morphine.