1.
Org Biomol Chem
; 8(20): 4524-6, 2010 Oct 21.
Article
in English
| MEDLINE
| ID: mdl-20733976
ABSTRACT
A highly efficient enantioselective α-amination of branched aldehydes with azadicarboxylates promoted by chiral proline-derived amide thiourea bifunctional catalysts was developed for the first time, affording the adducts bearing quaternary stereogenic centers with excellent yields (up to 99%) and enantioselectivities (up to 97% ee).