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1.
Micromachines (Basel) ; 14(11)2023 Nov 20.
Article in English | MEDLINE | ID: mdl-38004985

ABSTRACT

The liquid cooling system of lithium battery modules (LBM) directly affects the safety, efficiency, and operational cost of lithium-ion batteries. To meet the requirements raised by a factory for the lithium battery module (LBM), a liquid cooling plate with a two-layer minichannel heat sink has been proposed to maintain temperature uniformity in the module and ensure it stays within the temperature limit. This innovative design features a single inlet and a single outlet. To evaluate the performance of the liquid cooling system, we considered various discharge rates while taking into account the structure, flow rate, and temperature of the coolant. Our findings indicate that at a mass outflow rate of 20 g/s, a better cooling effect and lower power consumption can be achieved. An inlet temperature of 20 °C, close to the initial temperature of the battery string, may be the most appropriate because a higher temperature of the coolant will cause a higher temperature of LBM, so far as to exceed the safe threshold value. In the case of larger rate discharge, the design of a double-layer MCHS at the bottom and an auxiliary one at the side can effectively reduce the maximum temperature LBM (within 28 °C) and maintain the temperature difference in the single cell at approximately 4 °C. In the case of non-constant discharges, the temperature difference between cells increases with the maximum temperature. When the discharge rate is reduced, the large temperature difference helps the temperature to drop rapidly. This can provide guidance for the design of cooling systems for the LBM.

2.
Sensors (Basel) ; 23(17)2023 Aug 25.
Article in English | MEDLINE | ID: mdl-37687873

ABSTRACT

The performance of the calorimetric microflow sensor is closely related to the thermal sensing part design, including structure parameter, heater temperature, and operation environment. In this paper, several measures to enhance the performance of the calorimetric microflow sensor were proposed and further verified by numerical simulations. The results demonstrate that it is more favorable to reduce the negative impact of flow separation as the space between detectors and heater is set to be 1.6 µm so as to improve the accuracy of the sensor. With an appropriate gap, the front arranged obstacle of the upstream detector can effectively widen the measure range of the sensor, benefiting from the decrease in upstream viscous dissipation. Compared to a cantilever structure, the resonances can be effectively suppressed when the heater and detectors are designed as bridge structures. In particular, the maximum amplitude of the bridge structure is only 0.022 µm at 70 sccm, which is 53% lower than that of the cantilever structure. The optimized sensor widens the range by 14.3% and significantly increases the sensitivity at high flow rates. Moreover, the feasibility of the improved measures is also illustrated via the consistency of the trend between the simulation results and experimental ones.

3.
Micromachines (Basel) ; 14(5)2023 Apr 25.
Article in English | MEDLINE | ID: mdl-37241555

ABSTRACT

Heterogeneous integration (HI) is a rapidly developing field aimed at achieving high-density integration and miniaturization of devices for complex practical radio frequency (RF) applications. In this study, we present the design and implementation of two 3 dB directional couplers utilizing the broadside-coupling mechanism and silicon-based integrated passive device (IPD) technology. The type A coupler incorporates a defect ground structure (DGS) to enhance coupling, while type B employs wiggly-coupled lines to improve directivity. Measurement results demonstrate that type A achieves <-16.16 dB isolation and <-22.32 dB return loss with a relative bandwidth of 60.96% in the 6.5-12.2 GHz range, while type B achieves <-21.21 dB isolation and <-23.95 dB return loss in the first band at 7-13 GHz, <-22.17 dB isolation and <-19.67 dB return loss in the second band at 28-32.5 GHz, and <-12.79 dB isolation and <-17.02 dB return loss in the third band at 49.5-54.5 GHz. The proposed couplers are well suited for low cost, high performance system-on-package radio frequency front-end circuits in wireless communication systems.

4.
Neural Netw ; 163: 146-155, 2023 Jun.
Article in English | MEDLINE | ID: mdl-37054513

ABSTRACT

Deep neural networks are enjoying unprecedented attention and success in recent years. However, catastrophic forgetting undermines the performance of deep models when the training data are arrived sequentially in an online multi-task learning fashion. To address this issue, we propose a novel method named continual learning with declarative memory (CLDM) in this paper. Specifically, our idea is inspired by the structure of human memory. Declarative memory is a major component of long-term memory which helps human beings memorize past experiences and facts. In this paper, we propose to formulate declarative memory as task memory and instance memory in neural networks to overcome catastrophic forgetting. Intuitively, the instance memory recalls the input-output relations (fact) in previous tasks, which is implemented by jointly rehearsing previous samples and learning current tasks as replaying-based methods act. In addition, the task memory aims to capture long-term task correlation information across task sequences to regularize the learning of the current task, thus preserving task-specific weight realizations (experience) in high task-specific layers. In this work, we implement a concrete instantiation of the proposed task memory by leveraging a recurrent unit. Extensive experiments on seven continual learning benchmarks verify that our proposed method is able to outperform previous approaches with tremendous improvements by retaining the information of both samples and tasks.


Subject(s)
Learning , Neural Networks, Computer , Humans , Cognition , Mental Recall , Machine Learning
5.
J Prosthet Dent ; 129(1): 230-233, 2023 Jan.
Article in English | MEDLINE | ID: mdl-34011442

ABSTRACT

The digital fabrication of a maxillary obturator with a 3D-printed polyetheretherketone (PEEK) framework is described. Digital oral data were scanned for the computer-aided design (CAD) of the framework and the 3D printing of a preliminary resin cast. The framework was accurately printed from a PEEK filament material. A secondary impression was made to fabricate the definitive cast. The PEEK framework exhibited precise fit, excellent retention, and reduced weight compared with a typical metal framework.


Subject(s)
Maxillofacial Prosthesis , Polymers , Benzophenones , Polyethylene Glycols , Computer-Aided Design , Printing, Three-Dimensional , Ketones
6.
IEEE J Biomed Health Inform ; 27(2): 854-865, 2023 02.
Article in English | MEDLINE | ID: mdl-35259124

ABSTRACT

Edge intelligent computing is widely used in the fields, such as the Internet of Medical Things (IoMT), which has advantages, including high data processing efficiency, strong real-time performance and low network delay. However, there are many problems including privacy disclosure, limited calculation force, as well as scheduling and coordination issues. Federated learning can greatly improves training efficiency. However, due to the sensitive nature of the healthcare data, the aforementioned approach of transferring the patient's data to the servers may create serious security and privacy issues. Therefore, this article proposes a Privacy Protection Scheme for Federated Learning under Edge Computing (PPFLEC). First of all, we propose a lightweight privacy protection protocol based on a shared secret and weight mask, which is based on a random mask scheme of secret sharing. It is more accurate and efficient than,homomorphic encryption. It can not only protect gradient privacy without losing model accuracy, but also resist equipment dropping and collusion attacks between devices. Second, we design an algorithm based on a digital signature and hash function, which achieves the integrity and consistency of the message, as well as resisting replay attacks. Finally, we propose a periodic average training strategy, compared with differential privacy to prove that our scheme is 40 % faster in efficiency than in deferential privacy. Meanwhile, compared with federated learning, we can achieve the same efficiency under the condition of ensuring safety. Therefore, our scheme can work well in unstable edge computing environments such as smart healthcare.


Subject(s)
Internet of Things , Privacy , Humans , Computer Security , Delivery of Health Care , Algorithms
7.
IEEE J Biomed Health Inform ; 27(2): 732-743, 2023 02.
Article in English | MEDLINE | ID: mdl-36215343

ABSTRACT

The Internet of Medical Things (IoMT) is an important application of the Internet of Things in health care. In IoMT, efficiency and user privacy are crucial for cloud storage and retrieval of healthcare data documents. Existing schemes, however, often suffer from inefficient retrieval and increased risk of privacy disclosure when dealing with massive data. We propose here a new Efficient Encrypted Parallel Ranking (EEPR) search system, block-based and privacy-preserved, for encrypted cloud healthcare data. We design a parallel binary search tree structure in block and propose a parallel retrieval algorithm adaptable to such a structure. A quantitative analysis through the information retention index shows that our scheme demonstrates better search performance. In addition, feature vectors generated from our scheme are difficult to be reversely analyzed due to unexplainability, enhancing privacy protection for patients and researchers. A formal security analysis shows that our EEPR scheme is resistable to known background attack, and yields a lower time complexity and significantly improves search efficiency as well as accuracy over existing schemes.


Subject(s)
Computer Security , Privacy , Humans , Information Storage and Retrieval , Electronic Health Records , Algorithms , Cloud Computing , Delivery of Health Care
8.
Micromachines (Basel) ; 15(1)2023 Dec 25.
Article in English | MEDLINE | ID: mdl-38258165

ABSTRACT

This review presents a concise overview of RF (radio frequency) power transistor behavior models, which is crucial for optimizing RF performance in high-frequency applications like wireless communication, radar, and satellites. The paper highlights the significance of accurate modeling in understanding transistor behavior and traces the evolution of behavior modeling techniques. Different behavior modeling strategies, such as LUT (look-up table) based models, polynomial equation-based models, and machine learning based models, are discussed along with their unique characteristics and modeling challenges. The review explores the difference between behavior models and the conventional empirical or physics-based modeling approaches, addressing the challenges of the accurate characterization of transistors at high frequencies and power levels. This paper concludes with an outlook of emerging trends, such as physical models combined with behavior models, shaping the future of RF power transistor modeling for more efficient communication systems.

9.
PLoS Pathog ; 18(12): e1011036, 2022 12.
Article in English | MEDLINE | ID: mdl-36480554

ABSTRACT

Serine/arginine-rich (SR) proteins are well known as splicing factors in humans, model animals and plants. However, they are largely unknown in regulating pre-mRNA splicing of filamentous fungi. Here we report that the SR protein MoSrp1 enhances and suppresses alternative splicing in a model fungal plant pathogen Magnaporthe oryzae. Deletion of MoSRP1 caused multiple defects, including reduced virulence and thousands of aberrant alternative splicing events in mycelia, most of which were suppressed or enhanced intron splicing. A GUAG consensus bound by MoSrp1 was identified in more than 94% of the intron or/and proximate exons having the aberrant splicing. The dual functions of regulating alternative splicing of MoSrp1 were exemplified in enhancing and suppressing the consensus-mediated efficient splicing of the introns in MoATF1 and MoMTP1, respectively, which both were important for mycelial growth, conidiation, and virulence. Interestingly, MoSrp1 had a conserved sumoylation site that was essential to nuclear localization and enhancing GUAG binding. Further, we showed that MoSrp1 interacted with a splicing factor and two components of the exon-joining complex via its N-terminal RNA recognition domain, which was required to regulate mycelial growth, development and virulence. In contrast, the C-terminus was important only for virulence and stress responses but not for mycelial growth and development. In addition, only orthologues from Pezizomycotina species could completely rescue defects of the deletion mutants. This study reveals that the fungal conserved SR protein Srp1 regulates alternative splicing in a unique manner.


Subject(s)
Alternative Splicing , Ascomycota , Fungal Proteins , Oryza , Ascomycota/genetics , Oryza/microbiology , Serine-Arginine Splicing Factors/genetics , Fungal Proteins/genetics
10.
Micromachines (Basel) ; 13(11)2022 Oct 28.
Article in English | MEDLINE | ID: mdl-36363868

ABSTRACT

Heat-transfer enhancement in microchannel heat sinks (MCHS) has been a hot topic in the last decade. However, most published works did not focus on the heat sources that are discrete, as in most microelectronic devices, and the enhancement of heat and mass transfer (HMT) due to the Soret and Dufour effects being ignored. Based on a heterogeneous two-phase model that takes into consideration the Soret and Dufour effects, numerical simulations have been performed for various geometries and heat sources. The numerical results demonstrate that the vortices induced by a heat source(s) can enhance the heat transfer efficiency up to 2665 W/m2·K from 2618 W/m2·K for a discrete heat source with a heat flux q = 106 W/m2. The Soret effect can affect the heat transfer much more than the Duffour effect. The integrated results for heat transfer due to the Soret and Dufour effects are not sampled superpositions. Discrete heat sources (DHS) arranged in microchannels can enhance heat transfer, especially when the inlet velocity of the forced flow is less than 0.01 m/s. This can provide a beneficial reference for the design of MCHS with DHS.

11.
Micromachines (Basel) ; 13(7)2022 Jul 21.
Article in English | MEDLINE | ID: mdl-35888968

ABSTRACT

The miniaturization of components in mechanical and electronic equipment has been the driving force for the fast development of micro/nanosystems [...].

12.
Genomics Proteomics Bioinformatics ; 20(4): 728-746, 2022 08.
Article in English | MEDLINE | ID: mdl-34284133

ABSTRACT

Plant fungal pathogens secrete numerous proteins into the apoplast at the plant-fungus contact sites to facilitate colonization. However, only a few secretory proteins were functionally characterized in Magnaporthe oryzae, the fungal pathogen causing rice blast disease worldwide. Asparagine-linked glycosylation 3 (Alg3) is an α-1,3-mannosyltransferase functioning in the N-glycan synthesis of N-glycosylated secretory proteins. Fungal pathogenicity and cell wall integrity are impaired in Δalg3 mutants, but the secreted proteins affected in Δalg3 mutants are largely unknown. In this study, we compared the secretomes of the wild-type strain and the Δalg3 mutant and identified 51 proteins that require Alg3 for proper secretion. These proteins were predicted to be involved in metabolic processes, interspecies interactions, cell wall organization, and response to chemicals. Nine proteins were selected for further validation. We found that these proteins were localized at the apoplastic region surrounding the fungal infection hyphae. Moreover, the N-glycosylation of these proteins was significantly changed in the Δalg3 mutant, leading to the decreased protein secretion and abnormal protein localization. Furthermore, we tested the biological functions of two genes, INV1 (encoding invertase 1, a secreted invertase) and AMCase (encoding acid mammalian chinitase, a secreted chitinase). The fungal virulence was significantly reduced, and the cell wall integrity was altered in the Δinv1 and Δamcase mutant strains. Moreover, the N-glycosylation was essential for the function and secretion of AMCase. Taken together, our study provides new insight into the role of N-glycosylated secretory proteins in fungal virulence and cell wall integrity.


Subject(s)
Magnaporthe , Oryza , Virulence , Fungal Proteins/genetics , Fungal Proteins/metabolism , beta-Fructofuranosidase/metabolism , Secretome , Magnaporthe/genetics , Cell Wall/metabolism , Oryza/metabolism , Plant Diseases/microbiology
13.
Micromachines (Basel) ; 12(11)2021 Nov 05.
Article in English | MEDLINE | ID: mdl-34832778

ABSTRACT

Piezoelectric actuators are widely used in the field of micro- and nanopositioning due to their high frequency response, high stiffness, and high resolution. However, piezoelectric actuators have hysteresis nonlinearity, which severely affects their positioning accuracy. As the driving frequency increases, the performance of piezoelectric actuators further degrades. In addition, the impact of force on piezoelectric actuators cannot be ignored in practical applications. Dynamic hysteresis with force-voltage coupling makes the hysteresis phenomenon more complicated when force and driving voltage are both applied to the piezoelectric actuator. Existing hysteresis models are complicated, or inaccurate in describing dynamic hysteresis with force-voltage coupling. To solve this problem, a force-voltage-coupled Prandtl-Ishlinskii (FVPI) model is proposed in this paper. First, the influence of driving frequency and dynamic force on the output displacement of the piezoelectric actuators are analyzed. Then, the accuracy of the FVPI model is verified through experiments. Finally, a force integrated direct inverse (F-DI) compensator based on the FVPI model is designed. The experimental results from this study show that the F-DI compensator can effectively suppress dynamic hysteresis with force-voltage coupling of piezoelectric actuators. This model can improve the positioning accuracy of piezoelectric actuators, thereby improving the working accuracy of the micro- or nano-operating system.

14.
Entropy (Basel) ; 23(10)2021 Oct 11.
Article in English | MEDLINE | ID: mdl-34682049

ABSTRACT

Calculation of the thermal conductivity of nanofluids by molecular dynamics (MD) is very common. Regrettably, general MD can only be employed to simulate small systems due to the huge computation workload. Instead, the computation workload can be considerably reduced due to the coarse-grained fluid when multiparticle collision dynamics (MPCD) is employed. Hence, such a method can be utilized to simulate a larger system. However, the selection of relevant parameters of MPCD noticeably influences the calculation results. To this end, parameterization investigations for various bin sizes, number densities, time-steps, rotation angles and temperatures are carried out, and the influence of these parameters on the calculation of thermal conductivity are analyzed. Finally, the calculations of thermal conductivity for liquid argon, water and Cu-water nanofluid are performed, and the errors compared to the theoretical values are 3.4%, 1.5% and 1.2%, respectively. This proves that the method proposed in the present work for calculating the thermal conductivity of nanofluids is applicable.

15.
Polymers (Basel) ; 13(20)2021 Oct 13.
Article in English | MEDLINE | ID: mdl-34685268

ABSTRACT

Three-dimensional printing polyetheretherketone (PEEK) provides a new choice for dental prostheses, while its appropriate bonding procedure and adhesive performance are still unclear. This study aimed to investigate the adhesive performance of printed polyetheretherketone (PEEK) after acid etching to veneering resin. In total, 182 PEEK specimens (including 91 printed and 91 milled specimens) were distributed to 14 subgroups (n = 13/subgroup), according to the manufacturing process and surface treatment. The specimens were polished and etched with sulfuric acid for 0, 5, 30, 60, 90, 120, and 300 s, respectively. Two specimens in each subgroup were observed under a scanning electron microscope (SEM) for surface and cross-section morphology separately. Then, the specimens were treated with a bonding primer, and one specimen in each subgroup was prepared for cross-sectional observation under SEM. The residual 10 specimens of each subgroup bonded with veneering resin were tested with the shear bond strength tests (SBS) and failure modes analysis. Statistical analysis was performed by one-way ANOVA followed by the SNK-q post hoc test (p < 0.05). The etched pores on the PEEK surface were broadened and deepened under SEM over time. Printed PEEK etched for 30 s obtained the best SBS-to-veneering-resin ratio (27.90 ± 3.48 MPa) among the printed subgroups (p < 0.05) and had no statistical differences compared with milled PEEK etched for 30 s. The SBS of the milled subgroups etched from 5 to 120 s were over 29 MPa without significant between-group statistical differences. Hence, printed PEEK can be coarsened effectively by 30 s of sulfuric acid etching. The adhesion efficacy of printed PEEK to veneering resin was qualified for clinical requirements of polymer-based fixed dentures.

16.
Environ Microbiol ; 23(10): 5901-5916, 2021 10.
Article in English | MEDLINE | ID: mdl-34056823

ABSTRACT

The splicing factor Cwf15 is an essential component of the Prp19-associated component of the spliceosome and regulates intron splicing in several model species, including yeasts and human cells. However, the roles of Cwf15 remain unexplored in plant pathogenic fungi. Here, we report that MoCWF15 in the rice blast fungus Magnaporthe oryzae is non-essential to viability and important to fungal virulence, growth and conidiation. MoCwf15 contains a putative nuclear localization signal (NLS) and is localized into the nucleus. The NLS sequence but not the predicted phosphorylation site or two sumoylation sites was essential for the biological functions of MoCwf15. Importantly, MoCwf15 physically interacted with the Prp19-associated splicing factors MoCwf4, MoSsa1 and MoCyp1, and negatively regulated protein accumulations of MoCyp1 and MoCwf4. Furthermore, with the deletion of MoCWF15, aberrant intron splicing occurred in near 400 genes, 20 of which were important to the fungal development and virulence. Taken together, MoCWF15 regulates fungal growth and infection-related development by modulating the intron splicing efficiency of a subset of genes in the rice blast fungus.


Subject(s)
Magnaporthe , Oryza , Ascomycota , Fungal Proteins/genetics , Fungal Proteins/metabolism , Gene Expression Regulation, Fungal , Humans , Oryza/microbiology , Plant Diseases/microbiology , RNA Splicing Factors/genetics , RNA Splicing Factors/metabolism , Spores, Fungal/metabolism , Virulence/genetics
17.
Micromachines (Basel) ; 12(1)2021 Jan 16.
Article in English | MEDLINE | ID: mdl-33467202

ABSTRACT

Piezoelectric actuators are widely used in micro- and nano-manufacturing and precision machining due to their superior performance. However, there are complex hysteresis nonlinear phenomena in piezoelectric actuators. In particular, the inherent hysteresis can be affected by the input frequency, and it sometimes exhibits asymmetrical characteristic. The existing dynamic hysteresis model is inaccurate in describing hysteresis of piezoelectric actuators at high frequency. In this paper, a Dynamic Delay Prandtl-Ishlinskii (DDPI) model is proposed to describe the asymmetrical and dynamic characteristics of piezoelectric actuators. First, the shape of the Delay Play operator is discussed under two delay coefficients. Then, the accuracy of the DDPI model is verified by experiments. Next, to compensate the asymmetrical and dynamic hysteresis, the compensator is designed based on the Inverse Dynamic Delay Prandtl-Ishlinskii (IDDPI) model. The effectiveness of the inverse compensator was verified by experiments. The results show that the DDPI model can accurately describe the asymmetrical and dynamic hysteresis, and the compensator can effectively suppress the hysteresis of the piezoelectric actuator. This research will be beneficial to extend the application of piezoelectric actuators.

18.
Nanomaterials (Basel) ; 10(12)2020 Nov 29.
Article in English | MEDLINE | ID: mdl-33260487

ABSTRACT

Nanofluids are considered to be a next-generation heat transfer medium due to their excellent thermal performance. To investigate the effect of electric fields and magnetic fields on heat transfer of nanofluids, this paper analyzes the mechanism of thermal conductivity enhancement of nanofluids, the chaotic convection and the heat transfer enhancement of nanofluids in the presence of an applied electric field or magnetic field through the method of literature review. The studies we searched showed that applied electric field and magnetic field can significantly affect the heat transfer performance of nanofluids, although there are still many different opinions about the effect and mechanism of heat transfer. In a word, this review is supposed to be useful for the researchers who want to understand the research state of heat transfer of nanofluids.

19.
Micromachines (Basel) ; 11(6)2020 May 31.
Article in English | MEDLINE | ID: mdl-32486500

ABSTRACT

The sizes of most prokaryotic cells are several microns. It is very difficult to separate cells with similar sizes. A sorter with a contraction-expansion microchannel and applied magnetic field is designed to sort microparticles with diameters of 3, 4 and 5 microns. To evaluate the sorting efficiency of the designed sorter, numerical simulations for calculating the distributions of microparticles with similar sizes were carried out for various magnetic fields, inlet velocities, sheath flow ratios and structural parameters. The numerical results indicate that micro-particles with diameters of 3, 4 and 5 microns can be sorted efficiently in such a sorter within appropriate parameters. Furthermore, it is shown that a bigger particle size and more powerful magnetic field can result in a greater lateral migration of microparticles. The sorting efficiency of microparticles promotes a lower inlet velocity and greater sheath flow ratios. A smaller contraction-expansion ratio can induce a greater space between particle-bands. Finally, the micro particle image velocity (micro-PIV) experiments were conducted to obtain the bandwidths and spaces between particle-bands. The comparisons between the numerical and experimental results show a good agreement and make the validity of the numerical results certain.

20.
Micromachines (Basel) ; 11(4)2020 Mar 30.
Article in English | MEDLINE | ID: mdl-32235522

ABSTRACT

Because of fast frequency response, high stiffness, and displacement resolution, the piezoelectric actuators (PEAs) are widely used in micro/nano driving field. However, the hysteresis nonlinearity behavior of the PEAs affects seriously the further improvement of manufacturing accuracy. In this paper, we focus on the modeling of asymmetric hysteresis behavior and compensation of PEAs. First, a polynomial-modified Prandtl-Ishlinskii (PMPI) model is proposed for the asymmetric hysteresis behavior. Compared with classical Prandtl-Ishlinskii (PI) model, the PMPI model can be used to describe both symmetric and asymmetric hysteresis. Then, the congruency property of PMPI model is analyzed and verified. Next, based on the PMPI model, the inverse model (I-M) compensator is designed for hysteresis compensation. The stability of the I-M compensator is analyzed. Finally, the simulation and experiment are carried out to verify the accuracy of the PMPI model and the I-M compensator. The results implied that the PMPI model can effectively describe the asymmetric hysteresis, and the I-M compensator can well suppress the hysteresis characteristics of PEAs.

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