Oxidative addition of Bi-C bonds to Pt(0): reaction of Pt(PEt3)3 with cyclic organobismuth compounds.

The reaction of cyclic organobismuth compounds, 12-phenyl- and 12-chloro-5,6,7,12-tetrahydrodibenz[c,f][1,5]azabismocines, with Pt(PEt3)3 was examined. Oxidative addition of the exocyclic Bi-C bond to Pt(0) selectively took place in the reaction of the 12-phenyl derivative. Oxidative addition of the exocyclic Bi-Cl bond reversibly took place and was kinetically preferred, while endocyclic Bi-C bond oxidative addition products were thermodynamically favored and became the final products in the reaction of 12-chloro derivatives. These results demonstrate the oxidative addition of a Bi-C bond to a transition metal complex for the first time.

Comparison of clinicopathologic parameters and oncologic outcomes between type 1 and type 2 papillary renal cell carcinoma.

BACKGROUND: To compare the clinicopathologic parameters and oncologic outcomes between type 1 and type 2 papillary renal cell carcinoma (PRCC). METHODS: This study was approved by the review board (NO.XYFY2019-KL032-01). Between 2007 and 2018, 52 consecutive patients who underwent surgery at a single tertiary referral hospital were included. Clinicopathologic and survival data were collected and entered into a database. The Kaplan-Meier method, and univariate and multivariate Cox proportional hazard regression analyses were performed to estimate progression-free survival (PFS) and cancer-specific survival (CSS). RESULTS: Of the 52 patients, 24 (46.2%) were diagnosed with type 1 PRCC, and 28 (53.8%) had type 2 PRCC. The mean tumor size was 4.8 ± 2.5 cm. The two subtypes displayed different morphological features: foamy macrophages were more common in type 1 PRCC, while eosinophils and microvascular angiolymphatic invasion were more frequent in type 2 PRCC. Type 2 cases showed higher tumor stage and World Health Organization/International Society of Urological Pathology (WHO/ISUP) grade than type 1 cases (T3-T4: 43% vs 17%, P = 0.041; G3-G4: 43% vs 8%, P = 0.005). In univariate analysis, type 2 PRCC had a lower probability for PFS and CSS than patients with type 1 PRCC (P = 0.016, P = 0.049, log-rank test, respectively). In multivariate analysis, only WHO/ISUP grade (HR 11.289, 95% CI 2.303-55.329, P = 0.003) and tumor size (HR 1.244, 95% CI 1.034-1.496, P = 0.021) were significantly associated with PFS. CONCLUSIONS: PRCC subtype displayed different morphological features: foamy macrophages, eosinophils and microvascular angiolymphatic invasion are pathologic features that may aid in the distinction of the two subtypes. Histologic subtype of PRCC is not an independent prognostic factor and only WHO/ISUP grade and tumor size were independent predictors for PFS.

Efficient asymmetric hydrogenation of α-acetamidocinnamates through a simple, readily available monodentate chiral H-phosphinate.

An air-stable, simple (R(P))-mentylbenzylphosphinate, readily available in large quantities, can efficiently induce the rhodium-catalyzed asymmetric hydrogenation of α-acetamidocinnamates with high enantioselectivity (up to 99.6% ee). Intramolecular hydrogen bonding plays an important role in this asymmetric induction.

[Clinical diagnosis and analysis of cerebral cortical venous thrombosis].

OBJECTIVE: To investigate the clinical and radiological characteristics of cortical vein thrombosis for early diagnosis and treatment. METHODS: Retrospective analysis was carried out with the clinical cases of cortical vein thrombosis in 2010. The symptoms, sign, neuroimaging were analyzed and related literatures were reviewed. RESULTS: Four patients were collected, average age was forty years old. The main symptoms were headache and focal neurological signs in varying degrees, infarction or hemorrhage in one or two sides of parietal lobe could be found in CT or MRI. Hemorrhage was found in two patients, infarction was found in one patient, hemorrhage and infarction were both found in another patient. CONCLUSIONS: Headache and focal neurological signs are the common sings and symptoms of patients with cortical vein thrombosis. CT and MRI are effective methods for the diagnosis of cortical vein thrombosis.

[A clinical research of hirayama disease].

OBJECTIVE: To summarize and analyze the clinical features of Hirayama disease. METHODS: The authors summarized the clinical data of 29 cases of Hirayama disease in recent 9 years. RESULTS: All of the 29 cases were male and the age of onset was 12 - 25 years. 22 of the 29 patients only had the symptoms of one upper limb and 7 of them had symptoms of both upper limbs. Most of them had symptoms on the right or the symptoms were on more severe in the right than left, while only one case had symmetric symptoms of both upper limbs. The arm appeared as a slope, this was due to partial muscular atrophy. EMG indicated that the impairment of spinal anterior cells were limited to the arm relevant segments and both sides were involved. Cervical MRI scan suggested spinal atrophy at the level of C(5 - 7) vertebral bodies, being asymmetric in most of the cases. The atrophy was more obvious on the side with more severe symptoms. There was one patient whose MRI showed high T(2) signal in the spinal anterior cells of the C(5 - 6) segments. All the cases used cervical supporter and were followed up for 1 - 5 years. All of them had good prognosis. CONCLUSIONS: Hirayama disease is more common in men with hidden onset before 20 years of age. Most of the patients noted the symptoms of hands gradually about 2 years after a period of rapid growth in height in adolescence. The predominant clinical manifestations are as follows: atrophy of lower cervical cord in cervical MRI, asymmetric spinal atrophy in horizontal impaction and the degree of atrophy consistent with the symptoms of limbs. EMG could indicate bilateral spinal anterior impairment in lower cervical cord. Rare case may present the abnormal signal in the spinal cord, but pyramid signs were absent.

N-[(R)-1-(2-hydroxy-5-methylphenyl)ethyl]-N-[(R)-1-(2-methoxy-5-methylphenyl)-2-phenylethyl]aminium chloride.

The title compound, C25H30NO2+.Cl-, has been synthesized, and the crystal structure shows that it is mainly stabilized through intermolecular N-H...Cl and O-H...Cl and intramolecular N-H...O hydrogen bonds. The absolute configuration of the new stereogenic center (the C atom adjacent to the N atom on the phenol side) was determined to have an R configuration.