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1.
J Environ Manage ; 345: 118878, 2023 Nov 01.
Article in English | MEDLINE | ID: mdl-37659363

ABSTRACT

Light pollution is a global phenomenon where anthropogenic light sources continue to grow unabated, affecting both social and ecological systems. This is leaving parks and protected areas as some of the last vestiges of naturally dark environments for protecting views of the night sky. Yet, even parks and protected areas have outdoor lighting. Alternative lighting practices are needed to reduce or prevent light pollution from within parks. However, making parks darker may not be desirable for some visitors if they believe it will reduce navigability, safety, or restrict how they recreate (e.g., requiring the use of red-light flashlights after dark and before dawn). How visitors will respond to alternative lighting practices that park managers can implement is still unknown. We used an on-site intercept survey at nine state and national park units in Utah, U.S., to investigate nighttime visitors' support or opposition to management actions to protect night sky quality and their interest in learning about topics related to night skies. Further, this study also segmented visitors into two groups: those 'dependent' on the dark sky as a resource and those whose activities did not depend on a dark sky. Defining what a 'dark sky dependent' visitor is, which has yet to be done in the literature, is a fundamental step to furthering night sky research and management efforts. Across nine parks and protected areas, 62% of nighttime visitors participated in dark sky dependent activities. Findings indicate broad support for management actions designed to improve night sky quality, with between 74% and 89% of all visitors supporting seven different management actions. There was stronger support from dark sky dependent visitors for some elements of alternative lighting practices, but there was still strong support for those who do not participate in dark sky dependent outdoor recreation. Additionally, between 57% and 75% of visitors were interested in learning more about topics related to night skies. This research indicates most visitors would welcome actions to preserve the quality of the rapidly dwindling naturally dark experiences offered by parks and protected areas.


Subject(s)
Learning , Parks, Recreational , Dissent and Disputes , Ecosystem , Light
2.
Health Promot Pract ; 23(6): 944-949, 2022 11.
Article in English | MEDLINE | ID: mdl-33969724

ABSTRACT

System for Observing Play and Recreation in Communities (SOPARC) can provide accurate assessment of physical activity; however, the skills, time, and human resources necessary to collect/interpret SOPARC data can be challenging for community organizations. This article describes a more accessible adaptation of SOPARC using video recordings for community organizations to obtain physical activity feedback at Play Streets. Narrated panoramic video scans occurred every 30 minutes at each Play Street using an iPad. Videographers narrated: (1) sex, (2) age group (child, teen, adult, senior), and (3) activity level (sedentary, walking, vigorous) for everyone recorded. SOPARC video scans, in-person iSOPARC observations, and interviews were conducted with Play Streets implementors to determine validity and feasibility. Validity was examined using Lin's concordance correlation coefficient (CCC). In-person and video scans showed near perfect agreement for sedentary individuals (CCC = .95) and substantial agreement for active individuals (CCC = .72). Overall, community partners felt that they "could see how [the scans] could be useful" and "help[ed] see a bit more clearly what's happening." The method described here is a more accessible systematic observation approach to measure physical activity for communities implementing Play Streets. Further, this method can be used without research training while still providing valuable activity feedback.


Subject(s)
Exercise , Child , Adult , Adolescent , Humans
3.
Sci Rep ; 11(1): 2403, 2021 01 28.
Article in English | MEDLINE | ID: mdl-33510327

ABSTRACT

Daily weather affects total visitation to parks and protected areas, as well as visitors' experiences. However, it is unknown if and how visitors change their spatial behavior within a park due to daily weather conditions. We investigated the impact of daily maximum temperature and precipitation on summer visitation patterns within 110 U.S. National Park Service units. We connected 489,061 geotagged Flickr photos to daily weather, as well as visitors' elevation and distance to amenities (i.e., roads, waterbodies, parking areas, and buildings). We compared visitor behavior on cold, average, and hot days, and on days with precipitation compared to days without precipitation, across fourteen ecoregions within the continental U.S. Our results suggest daily weather impacts where visitors go within parks, and the effect of weather differs substantially by ecoregion. In most ecoregions, visitors stayed closer to infrastructure on rainy days. Temperature also affects visitors' spatial behavior within parks, but there was not a consistent trend across ecoregions. Importantly, parks in some ecoregions contain more microclimates than others, which may allow visitors to adapt to unfavorable conditions. These findings suggest visitors' spatial behavior in parks may change in the future due to the increasing frequency of hot summer days.

4.
Environ Manage ; 67(1): 120-132, 2021 Jan.
Article in English | MEDLINE | ID: mdl-33063153

ABSTRACT

Social media are being increasingly used to inform visitor use management in parks and protected areas. We review the state of the scientific literature to understand the ways social media has been, and can be, used to measure visitation, spatial patterns of use, and visitors' experiences in parks and protected areas. Geotagged social media are a good proxy for actual visitation; however, the correlations observed by previous studies between social media and other sources of visitation data vary substantially. Most studies using social media to measure visitation aggregate data across many years, with very few testing the use of social media as a visitation proxy at smaller temporal scales. No studies have tested the use of social media to estimate visitation in near real-time. Studies have used geotags and GPS tracks to understand spatial patterns of where visitors travel within parks, and how that may relate to other variables (e.g., infrastructure), or differ by visitor type. Researchers have also found the text content, photograph content, and geotags from social media posts useful to understand aspects of visitors' experiences, such as behaviors, preferences, and sentiment. The most cited concern with using social media is that this data may not be representative of all park users. Collectively, this body of research demonstrates a broad range of applications for social media. We synthesize our findings by identifying gaps and opportunities for future research and presenting a set of best practices for using social media in parks and protected areas.


Subject(s)
Social Media , Forecasting , Humans , Parks, Recreational , Recreation , Travel
5.
Am J Pharm Educ ; 84(1): 7122, 2020 01.
Article in English | MEDLINE | ID: mdl-32292187

ABSTRACT

Objective. To explore student pharmacists' shared experiences as they transitioned through the first three years of a Doctor of Pharmacy curriculum, from dependent learners to autonomous contributors. Methods. The researchers used interpretive phenomenology to examine the lived experiences of student pharmacists. Previously gathered focus group data for 309 student pharmacists from the 2015-2016 academic year were explored. A step-wise approach to data analysis was used to perpetuate the natural emergence of themes and alignment with theory. Utilizing Arthur Chickering's Seven Vectors of Identity Development as a lens, the researchers analyzed findings related to self-realization and identification of purpose. Results. The research team identified several themes associated with the teaching and learning process: professionalism, autonomy, and managing the expectations of the curriculum. A connection between the researchers' findings and Chickering's seven vectors was seen as students' comments demonstrated their progress along the vectors over three academic years. Conclusion. This exploration provided a glimpse into the lived experiences of student pharmacists at three different stages in their journey from dependent learners to autonomous contributors. By comparing students in one year with those in the next, the researchers were able to see the evolution that occurred over time as students became self-authored individuals, which is the ideal outcome for pharmacy graduates.


Subject(s)
Curriculum/statistics & numerical data , Education, Pharmacy/statistics & numerical data , Focus Groups/statistics & numerical data , Students, Pharmacy/psychology , Students, Pharmacy/statistics & numerical data , Adult , Female , Humans , Learning , Male , Perception , Pharmacies/statistics & numerical data , Pharmacists/psychology , Pharmacists/statistics & numerical data , Professional Role/psychology , Professionalism , Surveys and Questionnaires , Young Adult
6.
J Public Health Manag Pract ; 26(3): E1-E10, 2020.
Article in English | MEDLINE | ID: mdl-31033807

ABSTRACT

CONTEXT: Outdoor play has been described as essential for healthy childhood development. Lack of safety is one barrier to children participating in outdoor play. Play Streets are an intervention to help increase outdoor play by temporarily closing public streets (closures are recurring or episodic) to traffic, creating a safe place for active play. OBJECTIVE: This systematic grey literature review aimed to examine and describe what is known about implementing Play Streets using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework, which is widely used in implementation research. DESIGN: A systematic search for and review of nonacademic, or grey, literature was conducted using Academic Search Complete, Google Scholar, and a general Google search. ELIGIBILITY CRITERIA: Included literature was published in English, through December 2017, in nonacademic sources (ie, organizational/grant/municipal reports, newspapers, conference presentations, previous intervention advertisement materials, Web-based articles) or found in reference lists of academic articles about Play Streets, Pop-up Parks, or Open Streets/Ciclovías with a Play Street component. STUDY SELECTION: Resources were selected that documented Play Streets, which are defined as recurring or episodic temporary street closures to traffic that provide the public with a no-cost, safe space to actively play and be physically active. These approaches are designed primarily for youth and may include various marked play areas, loose equipment, and/or group activities. MAIN OUTCOME MEASURES: RE-AIM measures guided data extraction. RESULTS: Of the 36 articles composing the final sample, 100% reported on implementation, although the level of detail varied. Only 14 of 36 articles reported measures of effectiveness; limited information was provided for other RE-AIM components. CONCLUSIONS: In the grey literature, there are several inconsistencies in how the implementation of Play Streets is reported and level of detail. Specific details regarding implementing and evaluating Play Streets are needed to support widespread replication.


Subject(s)
Nature , Play and Playthings/psychology , Safety/standards , Adolescent , Child , Exercise/psychology , Gray Literature/standards , Gray Literature/statistics & numerical data , Humans , Safety/statistics & numerical data , Surveys and Questionnaires
7.
Res Q Exerc Sport ; 91(2): 346-353, 2020 Jun.
Article in English | MEDLINE | ID: mdl-31687924

ABSTRACT

Purpose: The System for Observing Play and Recreation in Communities (SOPARC) is a valid, reliable method for understanding how people engage in physical activity (PA) in various permanent settings (e.g., parks) and contexts. However, its utility, reliability, and validity in temporary spaces has not been examined. Temporary spaces can provide PA opportunities often absent in low-income communities due to inadequate safe permanent PA spaces. Play Streets involve temporary closure of streets or other publicly accessibly spaces (e.g., parking lots, open-fields) to create safe play spaces for a specified time-period. We describe the utility, reliability, and validity of using SOPARC to assess PA in temporary spaces like Play Streets. Method: Trained SOPARC/iSOPARC (iPad App) research staff completed systematic observations during Play Streets occurring in four diverse low-income rural U.S. communities during summer 2017. Results: We successfully used iSOPARC to document PA and how spaces were used at Play Streets (n = 16), confirming its utility, reliability, and validity. Unlike observations of permanent spaces, target areas could not be pre-established since play spaces often changed during set-up, requiring time onsite to identify target areas and boundaries. Play areas frequently appeared and/or disappeared during Play Streets, and this was systematically addressed by using physical target area boundaries instead of activities. Conclusions: Understanding how temporary spaces are used for PA is critical for promoting their use. SOPARC/iSOPARC methods are useful in a Play Streets' context; however, systematic methods and training are needed to address inherent unpredictable and dynamic changes within and across target areas.


Subject(s)
Built Environment , Exercise , Observation/methods , Adolescent , Adult , Child , Health Promotion/methods , Humans , Observer Variation , Poverty , Reproducibility of Results , Rural Population , United States
8.
Prev Med ; 129: 105869, 2019 12.
Article in English | MEDLINE | ID: mdl-31654727

ABSTRACT

Across the U.S., Play Streets - temporary street closures creating safe places for play for a few hours- are being implemented in urban areas during summer. Play Streets have never been implemented or evaluated in rural communities but have the potential to address challenges residents face accessing safe physical activity opportunities in these areas. Community organizations in four diverse low-income rural communities (selected to represent African American, American Indian, Latino, or White, non-Hispanic populations) received mini-grants in 2017 to implement four, three-hour Play Streets during the summer focusing on school-aged children in elementary-to-middle school. Physical activity was measured using Digi-walker (Yamax-SW200) pedometers and the System for Observing Play and Recreation in Communities (SOPARC/iSOPARC). Sixteen Play Streets were implemented in rural Maryland, North Carolina, Oklahoma, and Texas communities during June-September 2017. A total of 370 children (mean age = 8.81 years [SD = 2.75]; 55.0% female) wore pedometers across all 16 Play Streets (µâ€¯= 23.13 [SD = 8.59] children/Play Street). School-aged children with complete data (n = 353) wore pedometers for an average of 92.97 min (SD = 60.12) and accrued a mean of 42.08 steps/min (SD = 17.27), with no significant differences between boys (µâ€¯= 43.82, SD = 15.76) and girls (µâ€¯= 40.66, SD = 18.34). iSOPARC observations revealed no significant differences in child activity by sex; however, male teens were more active than female teens. Most adults were sedentary during Play Streets according to pedometer and iSOPARC data. Children in diverse rural communities are physically active at Play Streets. Play Streets are a promising intervention for promoting active play among children that lack safe opportunities to be active.


Subject(s)
Ethnicity/statistics & numerical data , Exercise/physiology , Play and Playthings , Rural Population , Accelerometry/statistics & numerical data , Adult , Child , Female , Humans , Male , Poverty , United States
9.
Health Aff (Millwood) ; 38(9): 1475-1483, 2019 09.
Article in English | MEDLINE | ID: mdl-31479352

ABSTRACT

Most US cities lack built environments that support physical activity, which is a key determinant of health. Making permanent changes to the physical environment to promote physical activity is not always feasible. Play Streets is a place-based intervention that is typically organized by local governments or community organizations and involves temporarily closing streets to create safe places and free opportunities for physical activity. In this descriptive study we examined 162 of Chicago's PlayStreets, held in the summer of 2018, to assess the volume and type of physical activity among youth participants and the variety of services provided to residents. We analyzed implementation data and forms completed after PlayStreets, and we conducted systematic observations at a purposeful sample of PlayStreets. We found that PlayStreets provides opportunities for youth physical activity in areas where opportunities do not otherwise always exist. PlayStreets also provides an avenue for residents to access community resources. This research on Chicago's experience with PlayStreets showed how one city is temporarily turning streets into places for youth physical activity to advance health equity. Local policies that facilitate temporarily closing streets and that provide resources to support opportunities for physical activity and access to community resources can advance health equity in cities nationwide.


Subject(s)
Environment Design , Exercise , Health Equity , Health Promotion , Urban Population , Adolescent , Adult , Behavior Observation Techniques , Chicago , Child , Female , Focus Groups , Humans , Interviews as Topic , Male , Qualitative Research , Surveys and Questionnaires , Young Adult
10.
Proc Natl Acad Sci U S A ; 116(26): 12775-12780, 2019 06 25.
Article in English | MEDLINE | ID: mdl-31160452

ABSTRACT

This research examines how the operating expenditures of America's state park systems will be affected by a continued growth in attendance consistent with observed trends as well as potential climate futures. We construct a longitudinal panel dataset (1984-2017) describing the operations and characteristics of all 50 state park systems. These data are analyzed with a time-varying stochastic frontier model. Estimates from the model are used to forecast operating expenditures to midcentury under four different scenarios. The first scenario assumes annual attendance within each state park system will continue to grow (or decline) at the same average annual rate that it has over the period of observation. The subsequent scenarios assume statewide annual mean temperatures will increase following the RCP2.6, RCP4.5, and RCP8.5 greenhouse gas emissions trajectories. Operating expenditures under a scenario where annual growth in attendance stays consistent with observed trends are forecasted to increase 756% by midcentury; this is an order of magnitude larger than projected expenditures under any of the climate scenarios. The future climate change scenarios yielded increases in operating expenditures between 25% (RCP2.6) and 61% (RCP8.5) by 2050. Attendance is the single largest factor affecting the operations of America's state park systems, dwarfing the influence of climate change, which is significant and nontrivial. The future of America's state park systems will depend upon increased support from state legislatures, as well as management actions that generate funds for the maintenance of existing infrastructure and facilities, and the provisioning of services.

11.
J Environ Manage ; 243: 88-94, 2019 Aug 01.
Article in English | MEDLINE | ID: mdl-31082755

ABSTRACT

In recent years, visitation to U.S. National Parks has been increasing, with the majority of this increase occurring in a subset of parks. As a result, managers in these parks must respond quickly to increasing visitor-related challenges. Improved visitation forecasting would allow managers to more proactively plan for such increases. In this study, we leverage internet search data that is freely available through Google Trends to create a forecasting model. We compare this Google Trends model to a traditional autoregressive forecasting model. Overall, our Google Trends model accurately predicted 97% of the total visitation variation to all parks one year in advance from 2013 to 2017 and outperformed the autoregressive model by all metrics. While our Google Trends model performs better overall, this was not the case for each park unit individually; the accuracy of this model varied significantly from park to park. We hypothesized that park attributes related to trip planning would correlate with the accuracy of our Google Trends model, but none of the variables tested produced overly compelling results. Future research can continue exploring the utility of Google Trends to forecast visitor use in protected areas, or use methods demonstrated in this paper to explore alternative data sources to improve visitation forecasting in U.S. National Parks.


Subject(s)
Parks, Recreational , Forecasting
12.
Phys Imaging Radiat Oncol ; 12: 49-55, 2019 Oct.
Article in English | MEDLINE | ID: mdl-33458295

ABSTRACT

BACKGROUND AND PURPOSE: Magnetic Resonance (MR)-Only radiotherapy requires a method for matching image with on-treatment Cone Beam Computed Tomography (CBCT). This study aimed to investigate the accuracy of MR-CBCT soft-tissue matching for prostate MR-only radiotherapy. MATERIALS AND METHODS: Three patient cohorts were used, with all patients receiving MR and CT scans. For the first cohort (10 patients) the first fraction CBCT was automatically rigidly registered to the CT and MR scans and the MR-CT registration predicted using the MR-CBCT and CT-CBCT registrations. This was compared to the automatic MR-CT registration. For the second and third cohorts (five patients each) the first fraction CBCT was independently matched to the CT and MR by four radiographers, the MR-CBCT and CT-CBCT matches compared and the inter-observer variability assessed. The second cohort used a CT-based structure set and the third a MR-based structure set with the MR relabelled as a 'CT'. RESULTS: The mean difference between predicted and actual MR-CT registrations was Δ R All = - 0.1 ± 0.2 mm (s.e.m.). Radiographer MR-CBCT registrations were not significantly different to CT-CBCT, with mean differences in soft-tissue match ⩽ 0.2 mm and all except one difference ⩽ 3.3 mm . This was less than the MR-CBCT inter-observer limits of agreement [ 3.5 , 2.4 , 0.9 ] mm (vertical, longitudinal, lateral), which were similar ( ⩽ 0.5 mm ) to CT-CBCT. CONCLUSIONS: MR-CBCT soft-tissue matching is not significantly different to CT-CBCT. Relabelling the MR as a 'CT' does not appear to change the automatic registration. This suggests that MR-CBCT soft-tissue matching is feasible and accurate.

13.
PLoS One ; 13(12): e0209013, 2018.
Article in English | MEDLINE | ID: mdl-30540834

ABSTRACT

How information is communicated influences the public's environmental perceptions and behaviors. Information channels and sources both play an important role in the dissemination of information. Trust in a source is often used as a proxy for whether a particular piece of information is credible. To determine preferences for information channels and trust in various sources for information on nature-related topics, a mail-out survey was sent to randomly selected U.S. addresses (n = 1,030). Diverse groups of people may have differing communication preferences. Therefore, we explored differences in channel preferences and trust by demographics using regression models. Overall, the most preferred channels were personal experience, reading online content, and watching visual media online. The most trusted sources were science organizations, universities, and friends/family. Channel preferences varied the most by education level and age, while source trust was most influenced by education, race, age, and size of current residence (rural-urban). The influence of demographics varied depending on the individual channel and source, with some groups preferring certain channels or sources but not others. Results are useful to consider when disseminating information on nature-related topics to a general public audience. More broadly, results also suggest spreading information using different channels and sources depending on the specific audience being targeted.


Subject(s)
Communication , Trust , Adolescent , Adult , Aged , Female , Humans , Internet/statistics & numerical data , Male , Mass Media/statistics & numerical data , Middle Aged , Surveys and Questionnaires , Young Adult
14.
Behav Brain Res ; 169(1): 93-7, 2006 Apr 25.
Article in English | MEDLINE | ID: mdl-16427145

ABSTRACT

Conditioned taste aversions (CTAs) can be established by exposing rats to a novel taste CS through a bottle or through intra-oral (IO) infusion. Lesion studies suggest differences between the two methods in their engagement of brain circuits, as excitotoxic amygdala lesions have no effect on bottle-conditioned CTAs, but eliminate CTAs produced using IO infusion. Fos-like immunoreactivity (FLI) was used to compare patterns of brain activation after pairing CS taste and US drug using bottle and IO methods. Conditioning rats using the bottle method was associated with widespread elevations in FLI throughout the putative CTA circuit (basolateral and central nuclei of amygdala, insular cortex and nucleus of the solitary tract). In contrast, IO conditioning led to activation only in the central nucleus of amygdala. This supports the suggestion of differences in aversion processing as a function of conditioning method and may explain the greater reliance on amygdala of IO-conditioned CTAs due to engagement of a less distributed neural network.


Subject(s)
Avoidance Learning/physiology , Conditioning, Psychological/physiology , Neural Pathways/metabolism , Proto-Oncogene Proteins c-fos/metabolism , Taste/physiology , Administration, Oral , Amygdala/metabolism , Animals , Association Learning/physiology , Avoidance Learning/drug effects , Behavioral Research/methods , Cerebral Cortex/metabolism , Drinking Behavior/drug effects , Drinking Behavior/physiology , Lithium Chloride/administration & dosage , Male , Rats , Rats, Long-Evans , Solitary Nucleus/metabolism , Taste/drug effects , Tissue Distribution
15.
Physiol Behav ; 86(4): 573-7, 2005 Nov 15.
Article in English | MEDLINE | ID: mdl-16212993

ABSTRACT

We previously reported that an intracerebroventricular (icv) injection of the oxytocin receptor antagonist ornithine vasotocin (OVT) caused water and saline intakes, a pressor response, and Fos-like immunoreactivity (Fos-IR) in the median preoptic nucleus of the rat brain. In the present report, rats receiving an icv injection of isotonic saline vehicle followed by an icv injection of 10 microg of OVT 20 min later drank 5.5+/-1.1 ml of total water and saline intake in 60 min after the OVT; rats receiving 10 microg of losartan before the OVT drank only 0.9+/-0.3 ml of total fluid. In a separate study, rats were treated as above except that they were not allowed to drink and were perfused for analysis of Fos-IR in the median preoptic nucleus at 90 min. Fos-IR in the dorsal part of the median preoptic nucleus was significantly suppressed from 2.69+/-0.57 cells per 10,000 square mum in vehicle-treated rats to 0.89+/-0.20 in losartan-treated rats. Losartan alone had no effect on Fos-IR. Losartan did not reduce intake of saccharin in a dessert test. This suggests that the OVT-induced drinking may result from an activation or disinhibition of angiotensin type AT1 receptors in the median preoptic nucleus.


Subject(s)
Angiotensin II Type 1 Receptor Blockers/pharmacology , Drinking Behavior/drug effects , Losartan/pharmacology , Vasotocin/analogs & derivatives , Vasotocin/pharmacology , Animals , Drinking/drug effects , Drug Interactions , Injections, Intraventricular , Male , Preoptic Area/drug effects , Preoptic Area/metabolism , Proto-Oncogene Proteins c-fos/metabolism , Rats , Rats, Long-Evans , Saccharin/pharmacology , Sodium Chloride/pharmacology
16.
Behav Neurosci ; 117(6): 1416-22, 2003 Dec.
Article in English | MEDLINE | ID: mdl-14674859

ABSTRACT

Taste novelty strongly modulates the speed and strength of taste aversion conditioning. To identify molecular signals responsive to novel tastes, immunostaining for c-fos protein (Fos-like immunoreactivity [FLI]) was used to mark neurons that responded differentially to taste novelty. Novel saccharin induced larger increases in FLI than familiar saccharin. This pattern was seen in central amygdala and insular cortex, but not in basolateral amygdala, parabrachial nucleus, or nucleus of the solitary tract. Other parameters known to influence aversion learning were tested for effects on FLI. Manipulations known to reduce the strength of learning blunted the FLI response, supporting the idea that FLI marks neural pathways critical to taste processing during acquisition, and that c-fos expression is a key transcriptional event underlying this plasticity.


Subject(s)
Amygdala/metabolism , Avoidance Learning/physiology , Cerebral Cortex/metabolism , Proto-Oncogene Proteins c-fos/metabolism , Taste/physiology , Animals , Exploratory Behavior/physiology , Male , Mental Processes/physiology , Practice, Psychological , Rats , Rats, Long-Evans , Tissue Distribution
17.
Learn Mem ; 10(5): 394-400, 2003.
Article in English | MEDLINE | ID: mdl-14557612

ABSTRACT

The effect of blockade of 5-HT1A receptors was investigated on (1). retention in a mildly aversive passive-avoidance task, and (2). spontaneous single-unit activity of central nucleus of the amygdala (CeA) neurons, a brain site implicated in modulation of retention. Systemic administration of the selective 5-HT1A antagonist NAN-190 immediately after training markedly-and dose-dependently-facilitated retention in the passive-avoidance task; enhanced retention was time-dependent and was not attributable to variations in wattages of shock received by animals. Systemic administration of NAN-190 had mixed effects on spontaneous single-unit activity of CeA neurons recorded extracellularly in vivo; microiontophoretic application of 5-HT, in contrast, consistently and potently suppressed CeA activity. The present findings-that 5-HT1A receptor blockade by NAN-190 (1). enhances retention in the passive-avoidance task, and (2). does not consistently increase spontaneous neuronal activity of the CeA-provide evidence that a serotonergic system tonically inhibits modulation of retention in the passive-avoidance task through activation of the 5-HT1A receptor subtype at brain sites located outside the CeA.


Subject(s)
Amygdala/drug effects , Avoidance Learning/drug effects , Piperazines/pharmacology , Receptor, Serotonin, 5-HT1A/physiology , Retention, Psychology/drug effects , Retention, Psychology/physiology , Serotonin Antagonists/pharmacology , Action Potentials , Amygdala/physiology , Animals , Avoidance Learning/physiology , Dose-Response Relationship, Drug , Electrophysiology , Male , Random Allocation , Rats , Rats, Long-Evans , Serotonin 5-HT1 Receptor Antagonists
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