Subject(s)
Arginine/metabolism , Cold Temperature , Escherichia coli/metabolism , Acetates/pharmacology , Biological Transport , Canavanine/pharmacology , Carbon Isotopes , Carboxy-Lyases/metabolism , Citrulline/metabolism , Glutamates/metabolism , Guanidines/metabolism , Hydrochloric Acid , Leucine/metabolism , Lysine/metabolism , Ornithine/metabolism , Osmolar Concentration , Proline/metabolism , Tromethamine , Urea/metabolismSubject(s)
Arginine/metabolism , Bacterial Proteins/pharmacology , Cold Temperature , Escherichia coli/metabolism , Bacterial Proteins/metabolism , Biological Transport/drug effects , Carbon Isotopes , Cellulose , Chromatography, Ion Exchange , Osmolar Concentration , Protein Binding , Stimulation, ChemicalSubject(s)
Amino Acids/metabolism , Kidney/physiology , Amino Acids/urine , Animals , Arginine/metabolism , Biological Transport , Carbon Isotopes , Cystine/metabolism , Glycine/metabolism , Hydroxyproline/metabolism , In Vitro Techniques , Lysine/metabolism , Male , Ornithine/metabolism , Proline/metabolism , Radiometry , RatsABSTRACT
In the report "Amino acid transport: evidence for genetic control of two types in human kidney" by C. R. Scriver and O. H. Wilson (17 Mar., p. 1428), the first sentence in the abstract should read "A mutation affecting renal transport of proline, hydroxyproline, and glycine occurs in man."
ABSTRACT
A mutation affecting renal transport of proline, hydroxyproline, and glycerine occurs in man. In the presumed homozygote there is still significant residual transport of these compounds; however, this remaining function is saturated at normal concentrations of substrate in the plasma and is not inhibited by L-proline in the expected way. The presumed heterozygote has partial loss of a transport system common to the three substrates, which becomes saturated at high concentrations of substrate and is inhibited by L-proline. Two different types of transport systems are proposed: a common system and systems with lower capacity and greater specificity. The two types of transport appear to be controlled by separate genes.
