Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.

Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning.

On the externalization of sound images.

Listeners perceive the sounds of the real world to be externalized. The sound images are compact and correctly located in space. The experiments reported in this article attempted to determine the characteristics of signals appearing in the ear canals that are responsible for the perception of externalization. The experiments used headphones to gain experimental control, and they employed a psychophysical method whereby the measurement of externalization was reduced to discrimination. When the headphone signals were synthesized to best resemble real-world signals (the baseline synthesis) listeners could not distinguish between the virtual image created by the headphones and the real source. Externalization was then studied, using both discrimination and listener rating, by systematically modifying the baseline synthesis. It was found that externalization depends on the interaural phases of low-frequency components but not high-frequency components, as defined by a boundary near 1 kHz. By contrast, interaural level differences in all frequency ranges appear to be about equally important. Other experiments showed that externalization requires realistic spectral profiles in both ears; maintaining only the interaural difference spectrum is inadequate. It was also found that externalization does not depend on dispersion around the head; an optimum interaural time difference proved to be an adequate phase relationship.

The reaction of ferrous leghemoglobin with hydrogen peroxide to form leghemoglobin(IV).

Ferrous leghemoglobin reacts with hydrogen peroxide to form the stable product, leghemoglobin(IV). The reaction follows second order kinetics (k = 2.24 X 10(4) M-1 S-1 at 20 degrees C) and may be regarded as a single-step, two-electron oxidation. Ferric leghemoglobin is not an intermediate. The oxidation state of leghemoglobin(IV) is established by reductive titration with dithionite; 2 eq of dithionite are required to convert 1 mol of leghemoglobin(IV) to ferrous leghemoglobin. An outstanding property of leghemoglobin(IV) is its stability, little change is noted after 12 h at 25 degrees C. Leghemoglobin(IV) differs from the higher oxidation states of other hemoglobins and myoglobins in that it does not react with hydrogen peroxide to form the oxygenated protein.