Structural insights into novel therapeutic deep eutectic systems with capric acid using 1D, 2D NMR and DSC techniques with superior gut permeability.

Therapeutic deep eutectic solvents (THEDSs) are the best exemplification of green alternative formulations of active pharmaceutical ingredients (APIs) that offer superlative properties of APIs. Previously, THEDESs of risperidone, fentanyl and levofloxacin with capric acid (CA) were developed by our group. These APIs share cyclic tertiary amine nuclei. Herein, DESs of two drugs bearing cyclic tertiary amine nucleus, namely, droperidol and aripiprazole, in the presence of CA, were investigated as model drugs. Comprehensive analyses were conducted using liquid-state 1D and 2D NMR and differential scanning calorimetry (DSC) to elucidate the regiochemistry and thermodynamic mechanisms bringing about those THEDESs. Everted gut sac technique was used to study the flux of the developed THEDESs. 1D and 2D NMR techniques analyses revealed the importance of cyclic tertiary amine nuclei in forming interactions with CA. This was confirmed by the downfield shift of the protons proximal to the tertiary amine groups compared to the individual drugs. Diffusion NMR analysis (DOSY) showed a significant reduction in the diffusion coefficient of CA in the mixed system compared with CA in isolation. Thermal analysis of the two drugs revealed that the drugs have a low tendency to recrystallise upon melting but rather vitrify from a melt to form an amorphous solid. Interestingly, the superior absorption and flux of the THEDES formulation of droperidol was demonstrated using the ERIS. Collectively, this work provides a green method to attain liquid formulations of APIs with enhanced pharmacokinetic features.

Narcissism and antisocial behaviour in sport: The moderating role of self-compassion.

Narcissism, which features the chronic disposition to seek the opportunity to construct and maintain an inflated self, is a known risk for antisocial behaviour. However, knowledge of factors that mitigate the effects of narcissism on antisocial behaviour is lacking. In two studies we explored the hypothesis that self-compassion would protect against the link between narcissism and antisocial behaviour, such that narcissism would be less related to antisocial behaviour when self-compassion was high. Study 1 was a cross-sectional study with a sample of professional footballers (N = 208). Study 2 utilised a sample of competitive athletes from a variety of sports (N = 324) over an eight-month period. The data from both studies supported the hypothesis: Greater self-compassion was associated with a null (Study 1) or significantly attenuated (Study 2) relationship between narcissism and antisocial behaviour. We discuss the implications of the findings, including the benefits of incorporating self-compassion in sport settings.

The impact of living in a bio-secure bubble on mental health: An examination in elite cricket.

The COVID-19 pandemic has had a profound impact on many people's lives, including the use of bio-secure environments to facilitate the continuation of professional sport. Although it is well documented that the pandemic has negatively impacted mental health, the impact of bio-bubbles on mental health is yet to be investigated. In the present study we sought to identify the impact of bio-bubbles on the mental health of those residing within, and then to explore the underlying mechanism of any such impact. Individuals (n = 68) who resided in England and Wales Cricket Board (ECB) created bio-bubbles between March 2020 and April 2021 provided data, regarding their time inside and outside of bio-bubbles, on measures of mental health and basic psychological need satisfaction and frustration. Analysis revealed that bio-bubbles increased anxiety and depression and reduced wellbeing. Additionally, MEMORE mediation analyses revealed that autonomy frustration mediated the relationship between bubble status and all mental health markers. Furthermore, compared to men, women were more likely to experience elevated levels of anxiety and depression inside the bubble. The findings suggest that bio-bubbles negatively impact mental health and further suggest that satisfaction and frustration of basic psychological needs is a contributing factor. Findings suggest organizations tasked with creating bio-bubbles would do well to tailor their environment with an awareness of the importance of basic psychological needs and sex differences in relation to mental health. To the best of our knowledge, this research represents the first investigation of the impact of bio-bubbles on mental health.

Pre-competitive anxiety and autonomic responses in professional U-20 futsal players: Effect of the competition phase and game location.

The study examined whether pre-competition anxiety and autonomic responses in elite futsal players change across the playoffs at away vs home venues. Heart rate variability, somatic and cognitive anxiety and self-confidence (by CSAI-2R questionnaire) were evaluated in nine male futsal players from a professional U-20 team, before competitive matches at the quarter-final, semi-final and final stages played at home and away venues. Two-way ANOVA for repeated measures was used, considering factor one the game location and factor two the playoff stage, with significance set at p<0.05. Significant effects of the playoff stage were demonstrated in the Mean of HR (F = 4.643; p = 0.014) and SD2 index (F = 14.83; p=<0.001)(quarter versus final). No difference was found for somatic and cognitive anxiety and self-confidence between the two factors. The results suggest that play at the final stage of the playoff, regardless of the game location, may cause higher physiological stress, demonstrated by elevated HR and decrease of SD2 index.

Bulls in a China Shop: Narcissism, Intragroup Conflict, and Task Cohesion.

When given opportunities for personal glory in individual settings, people high in narcissism excel. However, less is known about narcissists' influence in team contexts. Across two studies (utilizing cross-sectional and two-wave longitudinal designs) involving 706 athletes from 68 teams in total, we tested a conceptual model linking narcissism to task cohesion, via intragroup conflict, moderated by narcissistic group composition. We tested a new sports-oriented measure of intragroup conflict using Bayesian estimation and evaluated our theorizing using a multilevel conditional indirect effect hybrid model. Across both studies, we found that narcissism influenced perceptions of task cohesion via process conflict only, with a negative influence at low narcissistic group composition that was weakened (Study 1) or nullified (Study 2) at high narcissistic team composition. Collectively, these findings offer the first example of how narcissism influences task cohesion in team settings and the contextual effects of narcissistic group composition.

High-level athletes' motivation for sport and susceptibility to doping: The mediating role of eating behaviours.

Both doping (e.g. Hodge, K., Hargreaves, E. A., Gerrard, D. F., & Lonsdale, C. (2013). Psychological mechanisms underlying doping attitudes in sport: Motivation and moral disengagement. Journal of Sport and Exercise Psychology, 35, 419-432.) and eating behaviours (e.g. Hagger, M. S., Chatzisarantis, N. L., & Harris, J. (2006). From psychological need satisfaction to intentional behaviour: Testing a motivational sequence in two behavioural contexts. Personality and Social Psychology Bulletin, 32, 131-148.) have been studied independently within the SDT framework, but no research has examined these variables concomitantly to better understand the relationships between motivation for sport and doping variables. We therefore examined the mediating role of eating behaviour in the relationship between SDT constructs for sport motivation and athletes' susceptibility to doping. Bootstrapped mediation analyses were performed for 171 male and female athletes with competitive experience in various sports. The analyses revealed that healthy eating behaviours significantly mediated the relationship between SDT motivational constructs and susceptibility to doping. The findings enrich our theoretical understanding of how the SDT approach to motivation for sport might provide insight into the susceptibility to doping; that is, through the potential mediating role of healthy eating behaviours. Finally, the potential central position of eating behaviours in the motivation-doping relationship opens up a potential swathe of novel research, with investigations into eating behaviours at the forefront of future research on the psychology of doping.

The impact of menstrual-cycle phase on basal and exercise-induced hormones, mood, anxiety and exercise performance in physically active women.

BACKGROUND: The influence of menstrual cycle phase on perceptual responses and exercise performance is still unclear in the literature. Therefore, this study investigated salivary estradiol (sal-E2) and cortisol (sal-C) concentrations, mood, anxiety and exercise (aerobic, anaerobic) performance in physically-active women across two menstrual-cycle phases. METHODS: Twelve women (mean age 24.9±4.3 years) were assessed in the early follicular (early-FP) and mid luteal (mid-LP) phase of their menstrual cycle. In each phase, participants were tested for both aerobic (i.e. VO2max) and anaerobic (i.e. peak power, average power and Fatigue Index) performance. Basal and exercise-induced changes in sal-E2 and sal-C concentrations, self-appraised mood and anxiety were assessed. RESULTS: We observed a significant increase in basal (pre-exercise) sal-E2 concentration from early-FP to mid-LP (P≤0.05), coupled with a significant increase in VO2max in early-FP (39.9±7.8 mL/kg/min) versus mid-LP (36.9±7.8 mL/kg/min). Depression also decreased with aerobic exercise, but only in the early-FP. No other significant menstrual-phase differences in exercise performance, emotional state or hormonal change scores were identified. CONCLUSIONS: Our data suggest that physically-active women may experience a natural rise in estradiol concentration, as they transition from the early-FP to mid-LP. In the present study, this was accompanied by a small reduction in VO2max. An exercise (aerobic)-related decline in depression also emerged in the early-FP. Most of the exercise performance, emotional state and hormonal measures did not exhibit any menstrual phase-related difference.

Written Emotional Disclosure Can Promote Athletes' Mental Health and Performance Readiness During the COVID-19 Pandemic.

The widespread effects of the coronavirus disease 2019 (COVID-19) pandemic have negatively impacted upon many athletes' mental health and increased reports of depression as well as symptoms of anxiety. Disruptions to training and competition schedules can induce athletes' emotional distress, while concomitant government-imposed restrictions (e.g., social isolation, quarantines) reduce the availability of athletes' social and emotional support. Written Emotional Disclosure (WED) has been used extensively in a variety of settings with diverse populations as a means to promote emotional processing. The expressive writing protocol has been used to a limited extent in the context of sport and predominantly in support of athletes' emotional processing during injury rehabilitation. We propose that WED offers an evidence-based treatment that can promote athletes' mental health and support their return to competition. Research exploring the efficacy of the expressive writing protocol highlights a number of theoretical models underpinning the positive effects of WED; we outline how each of these potential mechanisms can address the multidimensional complexity of the challenging circumstances arising from the COVID-19 pandemic (e.g., loss of earnings, returning to training and competition). Considerations and strategies for using WED to support athletes during the COVID-19 pandemic are presented.

Watch out for the hazard! Blurring peripheral vision facilitates hazard perception in driving.

The objectives of this paper were to directly examine the roles of central and peripheral vision in hazard perception and to test whether perceptual training can enhance hazard perception. We also examined putative cortical mechanisms underpinning any effect of perceptual training on performance. To address these objectives, we used the gaze-contingent display paradigm to selectively present information to central and peripheral parts of the visual field. In Experiment 1, we compared hazard perception abilities of experienced and inexperienced drivers while watching video clips in three different viewing conditions (full vision; clear central and blurred peripheral vision; blurred central and clear peripheral vision). Participants' visual search behaviour and cortical activity were simultaneously recorded. In Experiment 2, we determined whether training with clear central and blurred peripheral vision could improve hazard perception among non-licensed drivers. Results demonstrated that (i) information from central vision is more important than information from peripheral vision in identifying hazard situations, for screen-based hazard perception tests, (ii) clear central and blurred peripheral vision viewing helps the alignment of line-of-gaze and attention, (iii) training with clear central and blurred peripheral vision can improve screen-based hazard perception. The findings have important implications for road safety and provide a new training paradigm to improve hazard perception.

I Am Great, but Only When I Also Want to Dominate: Maladaptive Narcissism Moderates the Relationship Between Adaptive Narcissism and Performance Under Pressure.

Narcissism-performance research has focused on grandiose narcissism but has not examined the interaction between its so-called adaptive (reflecting overconfidence) and maladaptive (reflecting a domineering orientation) components. In this research, the authors tested interactions between adaptive and maladaptive narcissism using two motor tasks (basketball and golf in Experiments 1 and 2, respectively) and a cognitive task (letter transformation in Experiment 3). Across all experiments, adaptive narcissism predicted performance under pressure only when maladaptive narcissism was high. In the presence of maladaptive narcissism, adaptive narcissism also predicted decreased pre-putt time in Experiment 2 and an adaptive psychophysiological response in Experiment 3, reflecting better processing efficiency. Findings suggest that individuals high in both aspects of narcissism perform better under pressure thanks to superior task processing. In performance contexts, the terms "adaptive" and "maladaptive"-adopted from social psychology-are oversimplistic and inaccurate. The authors believe that "self-inflated narcissism" and "dominant narcissism" are better monikers for these constructs.

Anxiety and Ironic Errors of Performance: Task Instruction Matters.

Five experiments that examined Wegner's theory of ironic processes of mental control in reactive motor performance under pressure are presented for the first time. In Experiments 1, 2, and 4, the authors conducted specific examinations of the incidence of an ironic error using a reactive motor task. In Experiments 3 and 5, they provided the first tests of whether task instruction moderates the incidence of ironic errors. The task required participants to react to a series of three primary-colored balls as they rolled down a chute under low- and high-anxiety conditions. Measures of anxiety, heart rate, heart-rate variability, and muscle activity confirmed the effectiveness of the anxiety manipulation. Experiments 1, 2, and 4 revealed that anxiety increased the number of ironic errors. In Experiments 3 and 5, the authors provided the first evidence that instructional interventions can reduce the incidence of anxiety-induced ironic performance errors in reactive motor tasks.

[German Language Version and Validation of the Risk-Taking Behaviour Scale (RBS-K) for High-Risk Sports]. / Deutschsprachige Übersetzung und Validierung der Risikobereitschaftskurzskala (RBS-K) für Risikosportarten.

BACKGROUND: High-risk sports, particularly climbing, kayaking and extreme skiing, have become increasingly popular. The most widely used psychological survey instrument with regard to risk behaviour in sports is the Sensation Seeking Model, mostly assessed by the Sensation Seeking Scale (SSS-V). Until recently, the literature discussed risk behaviour solely through this model. However, this scale does not measure risk-taking behaviours. In contrast, the Risk-Taking Behaviour Scale (RBS-K) is a three-item scale that measures risk behaviour in high-risk sports. This study aimed to validate a German language version of the RBS-K. METHODS: The RBS-K was translated and back-translated between English and German. High-risk sports participants (n = 2399) completed the German version of the RBS-K. Of those participants, 820 completed the RBS-K in person as part of a field survey and 1579 participated in an online survey. To validate the questionnaire, the SSS-V, accident involvement, age and sex were evaluated. The RBS-K divides the sample into deliberate risk takers (mean + standard deviation) and risk-averse persons (mean - standard deviation). We tested for internal consistency and correlations with SSS-V, age, sex and accident involvement. Group differences were calculated between deliberate risk takers and risk-averse persons. RESULTS: For internal consistency, we obtained a Cronbach's alpha of 0.56 and a McDonald's omega of 0.63. Significant correlations were shown between RBS-K and SSS-V as well as age and sex. Compared to risk-averse persons (n = 643, 26.8 %), deliberate risk takers (n = 319, 13.3 %) scored significantly higher in sensation seeking, were significantly younger and primarily male and had a significantly higher accident involvement. CONCLUSION: The RBS-K discriminates well for age, sex and accident involvement. Also, correlations between the RBS-K and the well-established SSS-V are acceptable. With regard to the results and its compact design, the scale seems to be well suited for field surveys. We discuss the relatively modest internal consistency in the context of the small number of items and the different dimensions of risk-taking.

Personality and performance: moving beyond the Big 5.

In this review, we examine the literature in relation to personality and performance. Much of the extant work in this area has focused on the role of the Big 5 traits (i.e., extraversion, conscientiousness, openness to experience, agreeableness, and neuroticism), at the expense of other personality variables that have a strong performance-focused rationale. Further, a focus on main effects has dominated the literature, without recourse to consider person×environment interactions. In this review we go beyond the Big 5 and consider the role of two personality traits, narcissism and alexithymia, in relation to performance. We demonstrate that both traits have considerable potential to explain differences in performance and that the personality-performance relationship is best viewed from an interactionist perspective. We close with a call for researchers to give more attention to personality in relation to performance.

Great British medalists: Psychosocial biographies of Super-Elite and Elite athletes from Olympic sports.

Participants were 32 former GB athletes from Olympic sports, 16 Super-Elite athletes who had won multiple medals at major championships, and 16 matched Elite athletes who had not. In-depth interviews with the athletes, their coaches, and one of their parents explored all psychosocial aspects of their development and careers. Content analyses revealed that there were no differences between Super-Elite and Elite athletes with regard to family values, conscientiousness, or commitment to training. However, the two groups were found to be different with regard to: (1) the experience of a foundational negative life event coupled with a foundational positive sport-related event; (2) the experience of a career turning point that enhanced motivation and focus for their sport; (3) need for success; (4) obsessiveness and/or perfectionism with regard to training and performance; (5) ruthlessness and/or selfishness in the pursuit of their sporting goals; (6) dual focus on both mastery and outcome; (7) the use of counterphobic attitudes and/or total preparation to maintain higher levels of performance under pressure; and (8) the relative importance of sport over other aspects of life. The results are discussed within the context of psychodynamic theory, and recommendations are made for both applied implications and future research.

Great British medalists: Response to the commentaries.

Hardy et al. (2017) reported the findings of a large-scale, multisource, qualitative study that examined the commonalities of, and discriminators between, a group of super-elite (SE) and a group of elite (E) athletes who were matched on gender, sport, discipline, and era. Fifteen research teams who are actively engaged in research in the domain then provided critical commentaries on the target paper. In our response to these commentaries, we briefly remind the reader of the primary findings of the original paper and then deal with the commentaries under the subheadings: Necessary and Sufficient Conditions for Elite Performance; Mediating and Moderating Variables; Methodological Issues; Omissions; and Alternative Approaches. Finally, we discuss the very small number of disagreements that we have with any of the commentaries.

Ironic and Reinvestment Effects in Baseball Pitching: How Information About an Opponent Can Influence Performance Under Pressure.

Are pressure-induced performance errors in experts associated with novice-like skill execution (as predicted by reinvestment/conscious processing theories) or expert execution toward a result that the performer typically intends to avoid (as predicted by ironic processes theory)? The present study directly compared these predictions using a baseball pitching task with two groups of experienced pitchers. One group was shown only their target, while the other group was shown the target and an ironic (avoid) zone. Both groups demonstrated significantly fewer target hits under pressure. For the target-only group, this was accompanied by significant changes in expertise-related kinematic variables. In the ironic group, the number of pitches thrown in the ironic zone was significantly higher under pressure, and there were no significant changes in kinematics. These results suggest that information about an opponent can influence the mechanisms underlying pressure-induced performance errors.

The Great British Medalists Project: A Review of Current Knowledge on the Development of the World's Best Sporting Talent.

The literature base regarding the development of sporting talent is extensive, and includes empirical articles, reviews, position papers, academic books, governing body documents, popular books, unpublished theses and anecdotal evidence, and contains numerous models of talent development. With such a varied body of work, the task for researchers, practitioners and policy makers of generating a clear understanding of what is known and what is thought to be true regarding the development of sporting talent is particularly challenging. Drawing on a wide array of expertise, we address this challenge by avoiding adherence to any specific model or area and by providing a reasoned review across three key overarching topics: (a) the performer; (b) the environment; and (c) practice and training. Within each topic sub-section, we review and calibrate evidence by performance level of the samples. We then conclude each sub-section with a brief summary, a rating of the quality of evidence, a recommendation for practice and suggestions for future research. These serve to highlight both our current level of understanding and our level of confidence in providing practice recommendations, but also point to a need for future studies that could offer evidence regarding the complex interactions that almost certainly exist across domains.

The Leader Ship Is Sinking: A Temporal Investigation of Narcissistic Leadership.

Individuals higher in narcissism have leader emergent tendencies. The characteristics of their personality suggest, however, that their leadership qualities will decrease over time as a function of group acquaintance. We present data from two studies that provide the first empirical support for this theoretical position within a transformational leadership framework. In Study 1 (N = 112), we tested narcissistic leadership qualities in groups of unacquainted individuals over a 12-week period. In Study 2 (N = 152), we adopted the same protocol with groups of acquainted individuals. In Study 1, narcissism was positively associated with peer-rated leadership during initial group formation but not later. In Study 2, narcissism was not significantly associated with peer-rated leadership during initial group formation and was negatively associated with peer-rated leadership later. In Study 1, transformational leadership mediated the relationship between narcissism and leadership initially but not later on. In Study 2, transformational leadership failed to mediate the relationship between narcissism and leadership throughout the study. Despite enjoying a honeymoon period of leadership, the appeal and attractiveness of the narcissistic leader rapidly wane. This decline is explained in part by their changing transformational leadership qualities.

Disordered eating in male athletes: a meta-analysis.

We examined the propensity for male athletes to exhibit symptoms of disordered eating. Using meta-analytic techniques, we examined overall effect size, individual effect sizes for specific sport types, standard of athletic competition and diagnostic tools from 31 studies. When all studies were considered as a homogeneous group, male athletes did not have symptoms of disordered eating that were significantly different from non-athletic controls. However, significant moderator effects emerged for sport type and measurement: (a) wrestling reported a greater incidence of disordered eating; and (b) studies that reported data from the Eating Attitudes Test yielded a significantly greater incidence of disordered eating in male athletes compared to non-athletes. Although some sports seem to present a higher risk of disordered eating compared to others, the effects are weak and heterogeneous. We make suggestions for the development of the research area, which has been severely hampered by the diagnostic tools that have been available for the study of men.