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Org Biomol Chem
; 21(25): 5185-5188, 2023 Jun 28.
Article
in English
| MEDLINE
| ID: mdl-37317819
ABSTRACT
A KOH-promoted cascade C-Cl bond activation and amidation of trichloromethyl aromatic compounds with formamides using water as a solvent has been developed. This methodology suggested an alternative synthetic approach for the synthesis of aryl amide compounds in the absence of catalysts, additives and organic solvents. In addition, the yields of gram-scale reactions are good and provide a basis for synthetic application.