ABSTRACT
OBJECTIVE: To investigate the factors influencing on the ephedrine contents in different compositions of Maxingshigan decoction. METHOD: Adopt mixed uniform design to dismantle recipes, employ the stepping regression analysis to deal with experimental statistics, use the partial correlational analysis to analyze the correlation coefficients and the results were validated. RESULT: The regressive equation was of significance, that is Y = 4.36719347 + 7.752707437X1 + 1.2557197041X3 (r = 0.85564, P = 0.0189). The main influencing factors on ephedrine content in Maxingshigan decoction were gypsum and amygdalin. The influent factor of amygdalin on ephedrine content had great significance, and gypsum had significance. CONCLUSION: The collective effects of amygdalin and gypsum affect the content of ephedrine in Maxing Shigan decoction which the content-effect relationship was in direct correlation.
Subject(s)
Amygdalin/chemistry , Calcium Sulfate/chemistry , Drugs, Chinese Herbal/chemistry , Ephedra sinica/chemistry , Ephedrine/analysis , Amygdalin/isolation & purification , Drug Combinations , Drugs, Chinese Herbal/isolation & purification , Glycyrrhiza uralensis/chemistry , Herb-Drug Interactions , Materia Medica/chemistry , Plants, Medicinal/chemistry , Prunus/chemistryABSTRACT
OBJECTIVE: To determine the contents of amygdalin in traditional and granular decoctions of Maxingshigan decoction. METHODS: The determination was carried out by HPLC with an ODS column and a mobile phase of water-methanol (23:77) at 215 nm. RESULTS: The content of amygdalin in traditional decoction of Maxingshigan Decoction was 17.74 mg/g and 24.80 mg/g in granular one. CONCLUSION: The content of glycyrrhizic acid in traditional decoction of Maxingshigan decoction is obviously higher than that in granular one.
