Usefulness of Focused Screening Echocardiography for Collegiate Athletes.

Sudden cardiac death in a young healthy athlete is a rare but catastrophic event. The American Heart Association preparticipation screening guidelines recommend a focused history and physical without routine imaging or electrocardiogram screening. We hypothesized that a focused echocardiogram can identify structural abnormalities that may lead to sudden cardiac death in athletes, which might otherwise go undetected by history and physical. We retrospectively reviewed the charts of all incoming collegiate athletes at a single university from 2005 to 2013, all of whom had undergone a focused, 5-minute echocardiogram along with a guideline-based preparticipation history and physical (PPS H&P). Abnormal findings prompted further testing or referral. We report the prevalence of abnormal findings and the relation between an abnormal PPS H&P and screening echocardiogram. A total of 2,898 athletes were screened and 159 (5%) had findings. Forty athletes underwent further testing and evaluation. Of these athletes, 3 had newly diagnosed abnormalities that warranted restriction of participation: 1 apical-variant hypertrophic cardiomyopathy, 1 large bidirectional atrial septal defect with right ventricular dysfunction, and 1 dilated ascending aorta. Two of these athletes had a normal PPS H&P. Conversely, of the 661 athletes with an abnormal PPS H&P, only 1 (0.15%) had an abnormal screening echocardiogram. In conclusion, although the overall number was low, the 5-minute screening echocardiogram detected athletes at risk for sudden cardiac death not discovered on PPS H&P.

The 5-minute screening echocardiogram for athletes.

BACKGROUND: Echocardiography is an accurate way to identify common cardiac abnormalities that lead to sudden death. We report a screening echocardiogram protocol incorporated into the routine athletic medical assessment for all incoming college freshman athletes. METHODS: A limited 2-dimensional echocardiogram was performed on athletes as part of a routine sports physical examination. The examination was performed by sonographers and senior cardiovascular medicine fellows and interpreted in real time by cardiologists using a 1-page checklist. No images were recorded. RESULTS: Of the 395 athletes representing 14 sports, 192 were female. The limited 2-dimensional echocardiogram took approximately 5 minutes per athlete. The majority of studies revealed normal findings (84%). A total of 55 had minor abnormalities not requiring follow-up. Five had abnormalities requiring a full echocardiogram and consultation with a cardiologist. CONCLUSION: This study demonstrates that a rapid screening echocardiogram is feasible and can be incorporated into the routine athletic medical examination for incoming varsity athletes.

Survey of current practices of the specialty of physicians interpreting cardiac and noncardiac findings of coronary computed tomographic angiography.

Computed tomographic angiography, as an imaging modality to evaluate the coronary arteries, has been rapidly expanding since the release of 64-slice machines. Little is known about current practice patterns. This study was conducted to evaluate current practice patterns and views regarding the interpretation of noncardiac findings by distributing a survey to the approximately 800 attendees of the first annual meeting of the Society of Cardiovascular Computed Tomography in 2006. Of the 214 returned surveys, 16% were completed by radiologists and 82% by cardiologists. Ninety-nine subjects were experienced readers. At very few centers (9%), cardiologists read the cardiac and noncardiac portions. Few (9%) believed that cardiologists alone adequately interpreted noncardiac findings. Most subjects (72%) in the experienced and novice groups believed that the interpretation of noncardiac findings required input from the radiologists (p = 0.896). In conclusion, most survey respondents believed that radiologists and cardiologists should be involved in interpretation of coronary computed tomographic angiograms. In addition, coronary computed tomographic angiography and computed tomography for lung cancer should not be used as a screening tool, although computed tomography for calcium scoring is a reasonable screening tool.

Does detection of carotid plaque affect physician behavior or motivate patients?

BACKGROUND: Imaging techniques to identify subclinical atherosclerosis are becoming more widespread, but few data exist regarding their influence on patient or physician behavior. We evaluated the impact of ultrasound screening to identify carotid artery plaques on physician treatment plans and patient motivation. METHODS: Subjects included asymptomatic patients without known vascular disease who had 2 or more cardiac risk factors. Circumferential scanning of the right and left carotid arteries to identify carotid plaques was performed using a handheld ultrasound device in an office setting. The physician's initial treatment recommendations were assessed before and after the results of the carotid scan were reported. Subjects completed a survey to assess motivation to make lifestyle changes before and after the results of the scan were provided. RESULTS: Fifty subjects were enrolled over 9 months. Their mean (SD) age was 54.0 (10.4) years and their mean Framingham 10-year cardiovascular risk was 7.8% (7.9%). More than half (58%) of the subjects had at least one carotid plaque. When carotid plaque was identified, physicians were more likely to prescribe aspirin (P = .031) and lipid-lowering therapy (P = .004). Although subjects with carotid plaque reported an increase in their perceived likelihood of developing heart disease (P = .013), they did not report increased motivation to make lifestyle changes. CONCLUSIONS: Ultrasound screening for carotid plaque in an office setting can alter physician treatment plans. Although the presence of plaque increased patient perception of cardiovascular risk, it did not motivate patients to make lifestyle changes.

An abbreviated carotid intima-media thickness scanning protocol to facilitate clinical screening for subclinical atherosclerosis.

BACKGROUND: Carotid intima-media thickness (CIMT) testing can assist with cardiovascular risk prediction; however, the requirement for rigorous, time-consuming protocols has limited it use in clinical practice. METHODS: Bilateral images of the common carotid artery (CCA), bulb, and internal carotid artery segments were obtained using a comprehensive scanning protocol. Three abbreviated scanning protocols were evaluated for their ability to identify patients with increased CIMT (> or = 75th percentile). RESULTS: Of 261 subjects, 134 (51.3%) had increased left or right CCA CIMT (CCA protocol), 136 (52.1%) had carotid plaque (plaque protocol), and 190 (72.7%) had plaque or at least one increased CCA CIMT (combination protocol). The area under the receiver-operator characteristic curves for the CCA (0.738) and combination protocols (0.692) were higher than the plaque protocol (0.625, P < .05). The combination protocol was 100% sensitive. CONCLUSIONS: Compared with a comprehensive scanning protocol, plaque screening with measurement of far wall CCA CIMT identifies all patients with increased CIMT.

Patchy myocardial fibrosis 20 years after radiation therapy.

We describe a case of a young woman diagnosed with Ewings sarcoma at age 8 and treated with adriamycin and radiation therapy. Twenty years later the patient has a cardiomyopathy and a focal area of patchy infiltration of fibrotic tissue along the left ventricle and atrium. Although fibrosis due to radiation exposure has been demonstrated on biopsy and autopsy studies, we are not aware of previous reports of echocardiographic demonstration of this finding. The most likely explanation for the fibrosis location is the left posterolateral direction of the radiation beam.

Is the ankle-brachial index a useful screening test for subclinical atherosclerosis in asymptomatic, middle-aged adults?

BACKGROUND: Measurement of the ankle-brachial index (ABI) is recommended as a screening test for cardiovascular risk prediction in individuals > or = 50 years old; however, there is little data regarding the utility of the ABI as a screening test in individuals for whom physicians actually order non-invasive testing for cardiovascular risk prediction. METHODS: This study included 493 consecutive asymptomatic patients without known atherosclerotic vascular disease who were referred by their physician for measurement of the ABI and ultrasound measurement of carotid intima-media thickness (CIMT). ABI values were classified as "reduced" (<0.9), "normal" (0.9-1.3), and "increased" (>1.3). RESULTS: The mean age of the patients was 55.3 (standard deviation 7.5) years. Only 1 patient had a reduced ABI (0.2%). ABI values tended to be higher in those with increased CIMT (P=0.051); however, CIMT was not significantly different between those with normal and increased ABI values (P=0.802). There were no significant differences in the prevalence of traditional cardiovascular risk factors or carotid plaque presence among the ABI groups. CONCLUSIONS: Despite recommendations, the ABI is not sensitive as a screening tool for detecting subclinical atherosclerosis in asymptomatic middle-aged individuals.

Use of carotid intima-media thickness and vascular age to modify cardiovascular risk prediction.

BACKGROUND: This study identified predictors of patients for whom carotid artery intima-media thickness (CIMT) measurement and determination of vascular age could change cardiovascular disease (CVD) risk assessment. METHODS: We studied consecutive patients who were asymptomatic and nondiabetic, referred for ultrasound measurement of CIMT. Individuals with CIMT 75th percentile or greater for age, sex, and race were defined as having advanced subclinical atherosclerosis. CIMT values were converted to vascular age estimates and were used to modify Framingham 10-year CVD risk estimates. RESULTS: Of 506 patients, 261 (51.6%) were not taking lipid-lowering therapy. Advanced subclinical atherosclerosis was present in 77 (30%). There were 62 patients (23.8%) with a change in CVD risk of 5% or more. Predictors of 5% or more change in CVD risk were systolic blood pressure (P < .001), total/high-density lipoprotein cholesterol ratio (P < .001), and male sex (P < .001). Of the 97 patients at moderate or moderately high risk, 56.7% changed risk classification. CONCLUSIONS: Measurement of CIMT and determination of vascular age can identify individuals with advanced subclinical atherosclerosis, resulting in clinically meaningful alterations in CVD risk estimates.

Ultrasound-detected carotid plaque as a predictor of cardiovascular events.

Ultrasound detection of carotid plaque can be performed with equipment that is available in many clinical settings and can identify patients at increased risk of cardiovascular (CV) disease. We reviewed the literature to determine the CV risk factors associated with the presence of carotid plaque and whether its presence is associated with the presence and extent of coronary artery disease. A MEDLINE search subsequently was performed to determine whether carotid plaque burden predicts future CV events. Studies that had more than 300 subjects and reported hazard ratios or relative risk estimates for CV events, or data from which these values could be calculated, were included. References from identified studies also were examined for inclusion in the review. Nine studies met these criteria. Although there was not a uniform definition of carotid plaque, eight studies found that the presence of carotid plaque predicted incident CV death and/or myocardial infarction. In several studies, this relationship persisted after adjustments for risk factors. Ultrasound detection of carotid plaque is a straightforward, inexpensive, and safe tool that has the potential to be used in an office setting to help clarify a patient's CV risk.

Ultrasound-detected carotid plaque as a screening tool for advanced subclinical atherosclerosis.

BACKGROUND: There is great need for a simple, noninvasive tool that can be used in an office setting to screen for subclinical atherosclerosis. In patients referred for cardiovascular (CV) risk assessment, we evaluated the ability of ultrasound screening for carotid plaque to identify patients with advanced subclinical atherosclerosis. METHODS: Consecutive asymptomatic patients without vascular disease referred by their physician for measurement of the ankle-brachial pressure index and carotid intima-media thickness (CIMT) were included. Carotid intima-media thickness was measured using the standardized ultrasound protocol from the Atherosclerosis Risk in Communities (ARIC) study. Advanced atherosclerosis was defined as CIMT > or = 75th percentile for age, sex, and race in ARIC. RESULTS: The mean age of the 327 subjects was 55.4 years (SD 7.7 years). The 10-year Framingham CV risk was 5.1% (4.8%). In a multiple logistic regression model that included Framingham CV risk, ankle-brachial pressure index, and use of lipid-lowering medications, plaque presence significantly predicted advanced atherosclerosis (odds ratio 3.08, 95% CI 1.91-4.96, P < .001). In stepwise regression models that included age, body mass index, current tobacco use, family history of premature CV disease, fasting glucose, sex, systolic blood pressure, total/high-density lipoprotein cholesterol ratio, and use of antihypertensive and lipid-lowering medications, plaque presence independently predicted advanced atherosclerosis (P < .001). CONCLUSION: Ultrasound detection of carotid plaque helped identify asymptomatic patients with advanced subclinical atherosclerosis. Screening for carotid plaque is easier than determination of CIMT and may help detect asymptomatic patients at increased CV risk.