Demographic profile of odontogenic and selected nonodontogenic cysts in a Brazilian population.

OBJECTIVE: To determine the demographic profile of all histologically diagnosed odontogenic cysts (OC) and nonodontogenic cysts (nOC) over a 51-year period in the Brazilian population. STUDY DESIGN: Case records of patients with OC and nOC from the files of the Oral Pathology Service, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil, during the period of 1953-2003 were evaluated. RESULTS: Among 19,064 oral biopsies, 2,905 (15.2%) presented criteria of OC and nOC. Of these, 2,812 specimens (14.7%) were diagnosed as OC and 93 (0.5%) represented nOC. The 3 most frequent OC diagnosed were radicular cyst (61.0%), dentigerous cyst (25.3%), and odontogenic keratocyst (7.2%). The most frequent nOC was the nasopalatine duct cyst (2.2%). CONCLUSION: Our results demonstrate that there is a wide range of OC and nOC, with some cysts having a predilection for age, gender, and localization. We also showed demographic aspects and clinical characteristics of these cysts. These could be used as baseline data to obtain more epidemiologic information about the OC and the nOC especially in the Brazilian population.

A functional interleukin-1 beta gene polymorphism is associated with chronic periodontitis in a sample of Brazilian individuals.

BACKGROUND: Interleukin-1 beta (IL-1 beta) is a potent inflammatory mediator and an important polymorphism in the locus +3954 (C/T) of the human IL1 B gene has been shown to affect the levels of this cytokine. This functional polymorphism has been associated with the establishment of inflammatory diseases, including periodontal disease, in European, Asian and North American populations. OBJECTIVE: The aim of this study was to investigate the association between the IL1 B (+3954) gene polymorphism and the occurrence of different clinical forms of periodontitis in a sample of Brazilian individuals. METHODS: This study employed a cross-sectional design involving individuals from the State of Minas Gerais in the south-eastern region of Brazil. Genomic DNA was obtained from oral swabs of 129 individuals and amplified using the polymerase chain reaction (PCR) with specific primers flanking the locus +3954 of IL1 B. PCR products were submitted to restriction endonuclease digestion and analyzed by polyacrylamide gel electrophoresis, to distinguish alleles T and C of the IL1 B gene, allowing for the determination of the genotypes and detection of the polymorphism. RESULTS AND CONCLUSIONS: The chronic periodontitis group displayed a higher percentage of the T allele (28%) when compared to the aggressive periodontitis group (10.7%, chi(2)=5.24, p=0.02, OR=0.31, CI=0.11--0.88) and to control group (8.7%, chi(2)=7.11, p=0.007, OR=0.24, CI=0.08--0.73). Our data suggested that the polymorphism in the locus +3954 of IL1 B gene could be a risk factor for chronic periodontitis in a sample of Brazilian individuals.