Laboratory earthquakes decipher control and stability of rupture speeds.

Earthquakes are destructive natural hazards with damage capacity dictated by rupture speeds. Traditional dynamic rupture models predict that earthquake ruptures gradually accelerate to the Rayleigh wave speed with some of them further jumping to stable supershear speeds above the Eshelby speed (~[Formula: see text] times S wave speed). However, the 2018 Mw 7.5 Palu earthquake, among several others, significantly challenges such a viewpoint. Here we generate spontaneous shear ruptures on laboratory faults to confirm that ruptures can indeed attain steady subRayleigh or supershear propagation speeds immediately following nucleation. A self-similar analysis of dynamic rupture confirms our observation, leading to a simple model where the rupture speed is uniquely dependent on a driving load. Our results reproduce and explain a number of enigmatic field observations on earthquake speeds, including the existence of stable subEshelby supershear ruptures, early onset of supershear ruptures, and the correlation between the rupture speed and the driving load.

Dynamic failure characteristics of surrounding rocks under different lateral pressure coefficients in deep tunnel transient excavation.

A novel transient unloading testing system was adopted to simulate the transient excavation of tunnels under different lateral pressure coefficients (k 0). The results show that the transient excavation of a tunnel induces significant stress redistributions and concentrations, particle displacements and vibrations to the surrounding rocks. The decrease of k 0 enhances the dynamic disturbance of transient tunnel excavation, and especially when k 0 = 0.4 and 0.2, the tensile stress can be observed on the top of the tunnel. The peak particle velocity (PPV) of the measuring points on the top of the tunnel decreases with the increasing distance between the tunnel boundary and measuring point. The transient unloading wave is generally concentrated on lower frequencies in the amplitude-frequency spectrum under the same unloading conditions, especially for lower k 0 values. In addition, the dynamic Mohr-Coulomb criterion was used to reveal the failure mechanism of a transient excavated tunnel by involving the loading rate effect. It is found that the excavation damaged zone (EDZ) of the tunnel is dominated by the shear failure, and the number of the shear failure zones increases with the decrease of k 0. The EDZ of tunnels after transient excavations varies from ring-shape to egg-shape and X-type shear with the decrease of k 0. The evolution of the EDZ induced by the transient unloading is associated with k 0, i.e., the shear failure of surrounding rocks mainly occurs in the stress redistribution stage under high k 0 (1.0-0.7), while the dramatic destruction of surrounding rocks is more prone to occur after the transient unloading process when k 0 ≤ 0.6.

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has become the dominant infective strain. We report the structures of the Omicron spike trimer on its own and in complex with angiotensin-converting enzyme 2 (ACE2) or an anti-Omicron antibody. Most Omicron mutations are located on the surface of the spike protein and change binding epitopes to many current antibodies. In the ACE2-binding site, compensating mutations strengthen receptor binding domain (RBD) binding to ACE2. Both the RBD and the apo form of the Omicron spike trimer are thermodynamically unstable. An unusual RBD-RBD interaction in the ACE2-spike complex supports the open conformation and further reinforces ACE2 binding to the spike trimer. A broad-spectrum therapeutic antibody, JMB2002, which has completed a phase 1 clinical trial, maintains neutralizing activity against Omicron. JMB2002 binds to RBD differently from other characterized antibodies and inhibits ACE2 binding.

BeiDou Short-Message Satellite Resource Allocation Algorithm Based on Deep Reinforcement Learning.

The comprehensively completed BDS-3 short-message communication system, known as the short-message satellite communication system (SMSCS), will be widely used in traditional blind communication areas in the future. However, short-message processing resources for short-message satellites are relatively scarce. To improve the resource utilization of satellite systems and ensure the service quality of the short-message terminal is adequate, it is necessary to allocate and schedule short-message satellite processing resources in a multi-satellite coverage area. In order to solve the above problems, a short-message satellite resource allocation algorithm based on deep reinforcement learning (DRL-SRA) is proposed. First of all, using the characteristics of the SMSCS, a multi-objective joint optimization satellite resource allocation model is established to reduce short-message terminal path transmission loss, and achieve satellite load balancing and an adequate quality of service. Then, the number of input data dimensions is reduced using the region division strategy and a feature extraction network. The continuous spatial state is parameterized with a deep reinforcement learning algorithm based on the deep deterministic policy gradient (DDPG) framework. The simulation results show that the proposed algorithm can reduce the transmission loss of the short-message terminal path, improve the quality of service, and increase the resource utilization efficiency of the short-message satellite system while ensuring an appropriate satellite load balance.

Opportunities and barriers for genetic service delivery in Kenya from a health personnel perspective.

Genetic counselling and testing are essential health services for the management of heritable diseases. However, in low-and-middle income countries like Kenya, genetic counsellors are not yet a licenced profession, and there is limited availability of and access to genetic testing. This study aimed to uncover opportunities and barriers for genetic service delivery in the Kenyan healthcare system from the perspectives of those who provide genetic testing and/or genetic counselling. Participants included Kenyan health personnel who deliver genetic services. This was a qualitative study that collected data via semi-structured one-on-one interviews and analyzed it using inductive thematic analysis. Participant demographics and characteristics of clinical genetic service provision were collected using a survey and results summarized using descriptive statistics. Themes revealed during analysis were compared to the clinical characteristics of genetic service provision to inform the opportunities and barriers. Fifteen interviews were conducted in total. Thematic analysis indicated that participants believed that the barriers facing genetic service delivery were linked to three themes: (1) education and training, (2) costs, and (3) counselling challenges. The opportunities for genetic service delivery were linked to four themes: (1) demand, (2) education and training, (3) encouraging a multidisciplinary approach to care, and (4) enhancing laboratory infrastructure. These findings are crucial for the development of a national evidence-informed and culturally appropriate model for genetic service delivery.

A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus disease-2019 (COVID-19), interacts with the host cell receptor angiotensin-converting enzyme 2 (hACE2) via its spike 1 protein during infection. After the virus sequence was published, we identified two potent antibodies against the SARS-CoV-2 receptor binding domain (RBD) from antibody libraries using a phage-to-yeast (PtY) display platform in only 10 days. Our lead antibody JMB2002, now in a Phase 1 clinical trial (ChiCTR2100042150), showed broad-spectrum in vitro blocking activity against hACE2 binding to the RBD of multiple SARS-CoV-2 variants, including B.1.351 that was reportedly much more resistant to neutralization by convalescent plasma, vaccine sera and some clinical-stage neutralizing antibodies. Furthermore, JMB2002 has demonstrated complete prophylactic and potent therapeutic efficacy in a rhesus macaque disease model. Prophylactic and therapeutic countermeasure intervention of SARS-CoV-2 using JMB2002 would likely slow down the transmission of currently emerged SARS-CoV-2 variants and result in more efficient control of the COVID-19 pandemic.

An experimental system to evaluate impact shear failure of rock discontinuities.

Conventionally, the evaluation of shear failure of discontinuities in rocks and other geomaterials has been conducted under static shear loading. In such methods, the shear failure behaviors of rock discontinuities are significantly influenced by loading velocities. To evaluate the shear failure process under dynamic loading, in this paper, we propose a new experimental methodology by taking advantages of recently available high-speed optical and mechanical measurement techniques. The methodology utilizes the Hopkinson bar to apply impact loading, and the diagnostics include a dynamic stress wave acquisition system, a digital image correlation (DIC) system, and an acoustic emission (AE) monitoring system. To improve the accuracy of the DIC analysis, an advanced digital speckle pattern and an updated water transfer printing are used to obtain the optimized and consistent speckle pattern. A flexible piezoelectric film sensor is first introduced to acquire AE signals in order to locate AE events accurately. A dynamic impact shear experiment indicates that the normal stress has a significant effect on the peak shear stress of rock discontinuities and the peak shear stress itself is rate dependent. The displacement field along shear directions is quantified using the DIC method, and the initial AE source locations during the impact shear process are determined using the AE monitoring system. We thus conclude that the dynamic impact shear system can systematically characterize the dynamic impact shear process with quantitative details and can further be implemented to study other dynamic impact failure behaviors of rock discontinuities under in situ stresses.

Dataset for time-lapse ultrasonic tomography of a granite slab under uniaxial compression test.

This data article includes raw data for time-lapse ultrasonic tomography measurements during a uniaxial compression test. Two sets of experimental data are included: first, the ultrasonic tomography (UT) observation (i.e., waveform) data at each 20 MPa axial stress step during the uniaxial loading test; and second, the stress-strain curve of the uniaxial compression test. A numerical model based on the combined finite-discrete element method (FDEM) was used to improve the understanding of the experimental results. The model file and the simulated acoustic emission (AE) data extracted from the simulation results are also included in this article. Data sets presented in this article help to improve understanding of the progressive rock failure process at microscopic and macroscopic scales.

A dynamic point-load test for quantifying rock dynamic strength parameters.

The point-load test (PLT) has been widely used in the field and in the laboratory to estimate the strength of rock materials. The PLT is easy and quick to perform and it is suitable for samples with irregular shapes and therefore has found wide applications. The measured point-load strength (PLS) is considered as a strength index and it has been correlated to the rock compressive strength. To address the engineering applications where the loading is dynamic, the PLT is extended to its dynamic version in this study. The dynamic loading is exerted to the rock specimen using a split Hopkinson pressure bar system. Two conical steel platens are attached to the incident bar and transmitted bar, respectively, to apply the point load to the disc specimen. To enable quasi-static analysis, the pulse shaper technique is utilized to achieve the dynamic force balance. The flexibility of the dynamic PLT method is demonstrated by the application to a well-studied granitic rock-Laurentian granite. The correlation between the dynamic PLS and the dynamic strength of the same rock is established.

Numerical Simulation on Seismic Response of the Filled Joint under High Amplitude Stress Waves Using Finite-Discrete Element Method (FDEM).

This paper numerically investigates the seismic response of the filled joint under high amplitude stress waves using the combined finite-discrete element method (FDEM). A thin layer of independent polygonal particles are used to simulate the joint fillings. Each particle is meshed using the Delaunay triangulation scheme and can be crushed when the load exceeds its strength. The propagation of the 1D longitude wave through a single filled joint is studied, considering the influences of the joint thickness and the characteristics of the incident wave, such as the amplitude and frequency. The results show that the filled particles under high amplitude stress waves mainly experience three deformation stages: (i) initial compaction stage; (ii) crushing stage; and (iii) crushing and compaction stage. In the initial compaction stage and crushing and compaction stage, compaction dominates the mechanical behavior of the joint, and the particle area distribution curve varies little. In these stages, the transmission coefficient increases with the increase of the amplitude, i.e., peak particle velocity (PPV), of the incident wave. On the other hand, in the crushing stage, particle crushing plays the dominant role. The particle size distribution curve changes abruptly with the PPV due to the fragments created by the crushing process. This process consumes part of wave energy and reduces the stiffness of the filled joint. The transmission coefficient decreases with increasing PPV in this stage because of the increased amount of energy consumed by crushing. Moreover, with the increase of the frequency of the incident wave, the transmission coefficient decreases and fewer particles can be crushed. Under the same incident wave, the transmission coefficient decreases when the filled thickness increases and the filled particles become more difficult to be crushed.

Note: A concrete erosion sensor based on a chirped fibre optic Bragg grating.

Erosion of concrete surfaces in major civil structures is a common problem, which in certain circumstances can undermine the structural and operational integrities of the structure. The manual monitoring of the erosion process can be difficult and dangerous under certain circumstances (such as within hydrotunnels and spillways of dams). This paper describes a concrete erosion sensor based on a chirped fibre Bragg grating (FBG) which is able to monitor the extent of concrete erosion at a single point to sub-millimetre accuracy. The chirped FBG length embedded below the concrete surface decreases as a result of concrete erosion and consequently the reflected light spectrum bandwidth narrows. A simple procedure is presented to determine the extent of erosion, and this procedure is applied to an experimental demonstration of the sensing device.

Laboratory earthquakes along inhomogeneous faults: directionality and supershear.

We report on the experimental observation of spontaneously nucleated ruptures occurring on frictionally held bimaterial interfaces with small amounts of wave speed mismatch. Rupture is always found to be asymmetric bilateral. In one direction, rupture always propagates at the generalized Rayleigh wave speed, whereas in the opposite direction it is subshear or it transitions to supershear. The lack of a preferred rupture direction and the conditions leading to supershear are discussed in relation to existing theory and to the earthquake sequence in Parkfield, California, and in North Anatolia.

Laboratory earthquakes: the sub-Rayleigh-to-supershear rupture transition.

We report on the experimental observation of spontaneously nucleated supershear rupture and on the visualization of sub-Rayleigh-to-supershear rupture transitions in frictionally held interfaces. The laboratory experiments mimic natural earthquakes. The results suggest that under certain conditions supershear rupture propagation can be facilitated during large earthquake events.