Study on traditional processing method of Mongolian medicine and excipient usage based on data mining / 中国中药杂志

This paper explores Mongolian medicine processing methods and the use regularity of excipient by text mining techniques. Relevant books of Mongolian medicine processing were consulted to collect data on Mongolian medicine processing methods and excipient, and select data based on processing methods and excipient noun frequency statistics. Microsoft Excel 2010 software was used for statistical analysis and mining for the usage regularity of different types of Mongolian medicinal materials in different periods. And Cytoscape 3.6.1 software was used for visual presentation. The topological analysis showed the top five processing methods were net production, development, frying, calcining and cooking, and the top five processing excipient were fresh milk, wine, urine, cream and mineral borax. Frequency analysis showed that the plant medicinal materials were mostly recorded in the 18~(th) and 21~(st) centuries, especially in the 21 st century; the processing methods mostly contained water processing, repair processing and other methods. The mineral medicinal materials were mostly recorded in the 18~(th), 19~(th) and 21~(st) centuries; most of the processing methods were the fire processing method. The animal medicinal materials were recorded in the 18~(th), 19~(th) and 21~(st) century; the fire processing method occupied a major position, and the repair processing and the grinding processing were markedly increased in the 21~(st) century. In the use of excipient, liquid excipient were mostly used in plant medicines. Solid excipient were most commonly used in the 18~(th) century. Animal excipient were mostly used during the processing in the 18~(th) century. The use of liquid excipient gradually increased in the 19~(th) and 21~(st) centuries. This study summarizes the traditional processing methods of Mongolian medicine and the usage regularity of excipient, defines the characteristics of Mongolian medicine processing methods and excipient, and the characteristics of the combination of medicinal materials and excipient, so as to provide reference for the clinical use of Mongolian medicine.

Application of " Basaga" in Mongolian Medicine Compound Preparations in Inner Mongolia / 中国实验方剂学杂志

" Basaga" is one of the commonly used medicinal materials in Mongolian medicine. It has a long history and effects in cooling blood, stopping stabbing pain and detoxifying. The " Basaga" in Mongolian medicine compound preparations have been widely used in various Mongolian hospitals because of its remarkable clinical efficacy. However, due to the differences in inheritance, medicinal parts and plants in Inner Mongolia, the phenomena of homonym and synonym in the application of " Basaga" have been very obvious, which leads to confusion in clinical use, and challenges the safety and effectiveness of this kind of Mongolian medicine. To understand the application of " Basaga" in Mongolian medicine compound preparation, and collect and summarize the types of " Basaga" preparations and the variety of " Basaga" used in preparations and formulations, functional indications and clinical applications were analyzed and collected based on standards and specifications of Mongolian medicine, the application of Mongolian medicine hospitals and Mongolian medicine hospital' s preparation room in Inner Mongolian, and relevant documents in recent years were reviewed. The data can provide references for optimizing and improving " Basaga" , Mongolian medicine standards and the overall standard level. What' s more, the basic data for strengthening the comprehensive development and research of " Basaga" in Mongolian medicine compound preparations in future, so as to ensure and improve the accuracy and clinical effectiveness of " Basaga" in prescriptions of Mongolian patent medicine, and lay a foundation for rational use and modern research of " Basaga" Mongolian medicine.

Status analysis and strategic thinking on Mongolian medicine standardization / 中国中药杂志

Standardization is the progress of human civilization. It is also an important technical system for normalizing economy and social development and a basic element in the core competitive power of a country. This paper emphasized on the importance of accelerating the standardization of Mongolian medicine for international development of national medicine and improving the international competitiveness. Summed up the Mongolian medicine standardization work achieved the stage results. Achievements on Mongolian medicine standardization were summarized and the existed problems were also analyzed. Such as, imperfect Mongolian medicine standard system and operation mechanism, the lack of application and personnel of Mongolian medicine. Corresponding measures, such as improving the Mongolian medicine standardization system and its support system construction; establishing personnel long-term training mechanism; the establishment of Mongolian medicine standard implementation-promotion-evaluation-feedback mechanism and other corresponding measures, were also provide.

Variety systematization and research progress of Mongolian medicine "Bashaga" / 中国中药杂志

Mongolian medicine is the traditional drug with the theory of Mongolian medicine and pharmacy as a guide, which made a great contribution to the survival and development of the Mongolian people. Mongolian medicine "Bashaga" faced the situations of origin is unclear, and clinical therapy is confused and so on. This paper summarizes the original plants and studies the species textual research and ethnopharmacology of Mongolian medicine "Bashaga". This paper intends to ensure authentic plant and provide comprehensive insight into the chemical constituents, pharmacology and application status of Mongolian medicine "Bashaga" to discuss the rationality of the confirmation in "Bashaga" authentic plant.

Effect of Bear Bile Powder and Its Succedaneum on Peripheral Blood and Bone Marrow Megakaryocytes in Mouse Model with Thrombocytopenia Induced by Cytosine Arabinoside / 中国实验血液学杂志

<p><b>OBJECTIVE</b>To investigate the effect of bear bile powder and ursodesxy cholic acid (UDCA) on peripheral blood, bone marrow megakaryocyte and immune organs in mouse model with thrombocytopenia, so as to provide a reference for studying the curative effects of bear bile powder and its succedaneum on thrombocytopenic purpura (TP).</p><p><b>METHODS</b>The mouse model with thrombocytopenia indued by cytosine arabinoside (Ara-C) was established, a total of 70 mice were randomly divided into normal group, model group, prednisone group, bear bile (middle and high dose) powder group and UDCA (middle and high dose) group. From the first day of making model mice in the each group, 0.4 ml/(20 g·d) corresponding drug was administered by infusion. At day 10 after treatment the peripheral blood, spleen and thymus organ index, the number of bone marrow megakaryocyte in each group were compared.</p><p><b>RESULTS</b>compared with the normal group, the Plt, WBC and megakaryocyte counts in model group decreased, the spleen index increased obviously (P<0.05), but the WBC count returned to normal by 10 days; after treatment, compared with model group, the Plt, WBC and megakaryocyte counts of treated groups increased, spleen index decreased significantly (P<0.05), but the WBC count in prednisone group decreased, which in bear bile powder (high) group and UDCA (high) group were particularly significant.</p><p><b>CONCLUSION</b>The bear bile powder and UDCA have been confirmed to have therapeutical effect on thrombocytopenia models induced by Ara-C, UDCA can substitute bear bile powder as a treatment drug for thrombocytopenic purpura.</p>

[The relationship between CD44 and immune escape in gastric carcinoma].

AIM: To study the relationship between CD44 and gastric carcinoma cells. METHODS: The rate and mean fluorecence intension of CD44 cells were detected by flow cytometry. RESULTS: The rate of CD44' cells was 93.46 ± 3.13% in gastric carcinoma which is higher than 21.27 ± 9. 59% in normal gastric mucosa ( P < 0. 05); The mean fluorecence intension of CD44 in gastric carcinoma was 175. 58 + 49. 21 which was no difference to 141. 02 ± 113.44 in normal gastric mucosa ( P > 0. 05). CONCLUSIONS: In gastric carcinoma, The increasing of CD44 protein indicated that it may play an important role in the occurrence, development and metabasis of gastric cancer.