A large-aperture, high-power ultrawideband radiation system with beam broadening capacity.

Due to the limited maximum output power of the pulsers based on avalanche transistors, high-power ultrawideband (UWB) radiation systems usually synthesize plenty of modules simultaneously to achieve a high peak effective potential (rEp). However, this would lead to an increased aperture size as well as a narrower beam, which would limit their applications in intentional electromagnetic interference fields. In this paper, a high-power UWB radiation system with beam broadening capacity is developed. To achieve beam broadening in the time domain, a power-law time delay distribution method is proposed and studied by simulation, and then the relative excitation time delays of the modules are optimized to achieve higher rEp and avoid beam splitting in the beam broadening mode. In order to avoid false triggering of the pulser elements when implementing the beam broadening, the mutual coupling effect in the system is analyzed and suppressed by employing onboard high-pass filters, since the mutual coupling effect is much more severe in the low-frequency range. Finally, a radiation system with 36 modules is developed. Measuring results indicate that in the high-rEp mode, the developed system could achieve a maximum effective potential rEp of 313.6 kV and a maximum pulse-repetition-rate of 20 kHz. In the beam broadening mode, its half-peak-power beam width in the H-plane is broadened from the original value of 3.9° to 7.9°, with a maximum rEp of 272.9 kV. The polarization direction of the system could be flexibly adjusted by a built-in motor.

Quantitative evaluation of CTP derived time-density alterations versus CTP for collateral status prediction with stroke.

BACKGROUND AND OBJECTIVES: Collateral status is a pivotal determinant of clinical outcomes in acute ischemic stroke (AIS); however, its evaluation can be challenging. We investigated the predictive value of CT perfusion (CTP) derived time and density alterations versus CTP for collateral status prediction in AIS. METHODS: Consecutive patients with anterior circulation occlusion within 24 h were retrospectively included. Time-density curves of the CTP specified ischemic core, penumbra, and the corresponding contralateral unaffected brain were obtained. The collateral status was dichotomised into robust (4-5 scores) and poor (0-3 scores) using multiphase collateral scoring, as described by Menon et al.. Receiver operating characteristic curves and multivariable regression analysis were performed to assess the predictive ability of CTP-designated tissue time and density alterations, CTP for robust collaterals, and favourable outcomes (mRS score of 0-2 at 90 days). RESULTS: One-hundred patients (median age, 68 years; interquartile range, 57-80 years; 61 men) were included. A smaller ischemic core, shorter peak time delay, lower peak density decrease, lower cerebral blood volume ratio, and cerebral blood flow ratio in the CTP specified ischemic core were significantly associated with robust collaterals (PFDR ≤ 0.004). The peak time delay demonstrated the highest diagnostic value (AUC, 0.74; P < 0.001) with 66.7 % sensitivity and 73.7 % specificity. Furthermore, the peak time delay of less than 8.5 s was an independent predictor of robust collaterals and favourable clinical outcomes. CONCLUSIONS: Robust collateral status was significantly associated with the peak time delay in the ischemic core. It is a promising image marker for predicting collateral status and functional outcomes in AIS.

Tightly coupled arrays with time-domain beam scan for the radiation of high-power ultrawideband electromagnetic pulses.

In this paper, a kind of tightly coupled array (TCA) with time-domain beam scan is developed for the radiation of high-power ultrawideband (UWB) electromagnetic pulses, and the peak-power pattern is proposed to characterize the directivity. First, the active voltage standing wave ratio (AVSWR) bandwidth of the TCA is optimized, which is the precondition for the beam scan. It indicates that the lower-cutoff frequency (LCF) is inversely proportional to the total length of the whole array; an increase in the distance between the array and the ground plane could remarkably reduce the LCF; and an increase in the element number can also decrease the LCF because of the increase in length, but more elements would make the center elements difficult to match in the low-frequency range, so there is a limitation on the number of elements for a certain LCF. Based on these results, a six-element linear array is designed. Then, the definition of the peak-power pattern is proposed to characterize the directivity of the UWB pulsed antenna. Finally, the optimized six-element array is developed, and the measured working band is 276 MHz-6.4 GHz (AVSWR < 3). The effective potential gain is 1.76, and it improves by 51.7% with a reduction in the aperture area by 68.4% compared with the previous TCA, which means that the aperture efficiency is remarkably improved. The half-power beam width of the developed TCA with the scan angle of 0° is 45°. The time-domain beam scan could be performed with time-delay feeding lines, and the maximum scan angle is over ±30° in the E-plane. The developed TCA can be applied for the generation of high-power electromagnetic environments for the study of intentional electromagnetic interference.

Development of a compact high-current repetitive pulsed x-ray system.

Pulsed x-rays are crucial for various applications such as radiography, biological effects, and the system-generated electromagnetic pulse effect. X rays with a higher dose rate and a higher total dose can generate more significant radiation effects and more effective radiography. However, most pulsed sub-100 keV x-ray systems with high dose rates operate in the single pulse mode with limited total dose, and most repetitive pulsed x-ray systems have a low dose rate. This paper develops a compact high-current repetitive pulsed x-ray system with a low-impedance diode to generate high dose rate pulsed x-rays with an average energy below 100 keV. A diode with a double-ring cathode is designed and tested to produce uniform pulsed x-rays. In order to investigate the x-ray intensity and the pulse number of repetitions for different anode thicknesses, five typical thicknesses are tested. The experimental results show that this system can operate stably at a repetitive rate of 0.2 Hz with a peak voltage of about 200 kV and a peak current of about 100 kA. The dose rate is about 2.4 × 105 Gy(LiF)/s, and the average x-ray energy is about 55 keV with the 40 µm thick tantalum anode. The x-ray uniformity is better than 2:1 over the measuring plane.

A miniatured helical antenna based on the sinusoidal folding structure with exponential spacing.

An exponential spacing and sinusoidal folded helical (ESSFH) antenna backed with a cavity is developed in this paper. Compared with the conventional helical (CH) antenna, the proposed antenna not only has smaller dimension but also exhibits a wider working bandwidth, a higher gain, and a better circular polarization (CP) characteristic. To reduce the dimension of the helical antenna, a sinusoidal structure is adopted along the circumference of the helix. However, it deteriorates the CP characteristic of the antenna. Therefore, the structure of the exponential helix spacing is introduced into the sinusoidal folded helical (SFH) antenna. Then, to further improve the gain of the ESSFH antenna, its ground plane is replaced by an optimized cavity. Compared with the CH antenna, the helix diameter of the ESSFH antenna Dλ is reduced from 0.32 to 0.23, and its volume is reduced to 53%. The ESSFH antenna backed with a cavity has an impedance bandwidth of 0.43-1.02 GHz, which is much wider than 0.48-0.60 GHz of the CH antenna. Moreover, it has an axial ratio of 1.77, while the axial ratio of the CH antenna is 2.61. In addition, its effective potential gain is 0.56, which is 22% higher than that of the CH antenna.

A modularized high-power ultra-wideband radiation system based on the space-synthesis method.

In this paper, a high-power ultra-wideband radiation system, composed of multiply radiation modules, is developed based on the space-synthesis method. The radiation module mainly consists of a transistorized pulser, a 2 × 2 combined antenna array, and a power divider. To improve the out parameters [the amplitude, the pulse repetition frequency (PRF), and the rise time] of the transistorized pulser based on the Marx circuit, the influence of the traveling wave process on the output pulse must be concerned. Based on the theoretical analysis, the printed circuit board circuit parameters and the circuit structure of the pulser are optimized. To improve the power synthesis efficiency, the pulse jitter characteristic of the pulser is improved by replacing the conventional base triggering mode with the collector voltage ramp triggering mode for the first-stage avalanche transistor in the pulser. The previous optimized antenna array is utilized in this radiation system, which has a better radiation performance in the prescribed aperture area. In addition, based on the gradient microstrip structure, the power divider integrated with the pulser is designed, which has the advantages of wide bandwidth, low loss, and light weight. Experimental results show that the peak effective potential rEp of the radiation system of 20 radiation modules is 221.8 kV, the maximum PRF could reach 10 kHz, and the half-power radiation angles of its radiation field are about 5° in both the E plane and the H plane. More radiation modules could be integrated into the system to achieve a higher electric field in the future.

A broadband optical fiber transmission-based time domain measurement system for nanosecond-level transient electric field.

A novel nanosecond transient electric field (E-field) measurement system is developed in this paper to measure the E-field pulse caused by the operation of the high-voltage switch (switching E-field pulse) in the substation. An electrically small rod antenna is used as the receiving antenna and is matched by the operational amplifier with high input impedance to achieve broadband frequency response and stable working performance. A broadband analog optical fiber transmission system is further designed based on the high-frequency circuit model of the electronic components. Unlike the traditional frequency domain E-field measurement methods, the developed measurement system can directly output the time domain waveform of the switching E-field pulse. It also has the advantages of adjustable sensitivity, portability, and anti-electromagnetic interference. The calibrated measurement bandwidth ranges from 200 Hz to 680 MHz. Furthermore, the switching E-field pulse in an ultra-high voltage substation is measured and analyzed to verify the effectiveness of the fabricated measurement system.

A compact narrow-width combined antenna for the radiation of the UWB electromagnetic pulses.

In this article, a Narrow-Width Combined Antenna (NWCA) is proposed for the compact design of high-power ultra-wideband (UWB) systems. The dependence of performances on three dimensions of the combined antenna is investigated so as to minimize its size with a given excitation. It indicates that the working process of the combined antenna can be divided into two stages: (1) energy transmitted from the feeding point to the aperture by the TEM horn structure, and during this stage, the passband is determined by the effect of the impedance taper, which is related to the length and aperture impedance of the antenna, and (2) energy radiated to the free space from the aperture, during which the height of the aperture is the dominant factor. Therefore, the three dimensions of the combined antenna can be appropriately adjusted to make the antenna more compact. Thus, the NWCA is designed by reducing the width and making a slight compensation in height and/or length. Compared with the conventional cubic antenna, the aperture area of the developed NWCA is reduced by 47%, whereas the amplitude of the radiating field only reduces by 2.5% with the given pulsed excitation at the cost of a slight decrease in the pulse duration. It demonstrates that the NWCA is an effectively compact design for the combined antenna in the application of the radiation of the high-power UWB pulse.

A high-efficiency wideband coupler for nanosecond-level pulsed current injection.

Pulsed current injection (PCI), as a conducted vulnerability testing technique under nanosecond-level transient electromagnetic disturbance (TED), has gained great attention recently. Many kinds of TEDs, e.g., high-altitude electromagnetic pulse, very fast transient overvoltage, and electrical fast transients, have very fast rise time as well as pretty slow decay, whose frequency spectrum may cover a very wideband. Therefore, one of the challenges is that the existing inductive couplers cannot interact with the equipment under test (EUT) over the wideband efficiently, and consequently, they are inadequate to inject the proper disturbance at ports of EUT in PCI tests. To address this problem, a high-efficiency wideband PCI coupler is proposed in this paper. The coupling performance is analyzed theoretically based on the distributed-parameter model of an inductive coupler. By using the composited ferrites instead of the simplex Ni-Zn ferrites, the inductive coupling is enhanced. The capacitive coupling is also enhanced to improve the high-frequency performance by exploiting the distributed tubular winding. A PCI coupler with the dimension of 30 × 10 × 10 cm3 is built to be validated experimentally. The 3 dB bandwidth has been improved from 421 kHz-14 MHz to 77 kHz-39 MHz, which indicates that the coupler can be applied efficiently over the frequency range of interest for PCI tests.

Development of a type of differential switched oscillator system for the radiation of mesoband high-power electromagnetic pulses.

In this Note, a type of Differential Switched Oscillator (DSWO) system is developed and compared with the conventional single-ended switched oscillator; the power capacity of the DSWO is twice with the same insulation level and twice total length. The DSWO system consists of a differential high-voltage pulsed source, a DSWO, and a pair of differential helical antennas. The differential pulsed source is based on the hydrogen thyratron and pulsed transformer whose peak voltage can theoretically reach ±100 kV to break down the high-pressure switch, whose limiting gas pressure is 25 atm; the DSWO is designed to generate a damped oscillation pulse with a central frequency of 300 MHz, which is also the central frequency of the differential helical antennas. Thus, a damped oscillation pulse can be produced and radiated to generate high-power mesoband circularly polarized electromagnetic fields, and the axial ratio is 1.98. According to the measured results, the central frequency of the developed DSWO is 284 MHz, the percent bandwidth of the radiating field is 11%, and the amplitude of the far-field effective potential is 105 kV.

A transient electromagnetic disturbance testing system based on low-frequency-compensated symmetric TEM horn antenna.

A transient electromagnetic disturbance (TED) testing system with an adjustable direction of polarization is developed in terms of a low-frequency-compensated symmetric transverse electromagnetic (TEM) horn antenna in this paper. TEM horn antennas are deficient in the low-frequency radiation, which would lead to a very narrow pulse width and cannot be directly applied in radiation tests of TED, especially the TED with abundant low-frequency components such as fast transient overvoltage and high-altitude electromagnetic pulse. To address this problem, a theoretical radiation model and a design principle of the back-loading method are proposed to compensate for the low-frequency performance. After the optimization of the structure according to the simulated results, a TED testing system with the aperture width of 0.9 m and the length of 1.8 m is built. The rise time of the electric field measured at the center of the aperture is 2.39 ns, the pulse width is 27.65 ns, and the peak field is over 50 kV/m, which can meet the requirements of relative standards. The dimension of the working volume is estimated as 0.4 × 0.5 × 0.5 m3 according to the field distribution.

High power and high pulse repetition frequency transistorized pulser by time base stability improvement and power synthesis technique.

Output power of a transistorized pulser is usually limited by the power capacity of avalanche transistors. To improve the total output power, the power synthesis method is widely used, in which a single pulser with high output power and high time base stability is required. However, the time base stability tends to deteriorate as the output power increases. To improve the output power under the premise of high time base stability, from the perspective of carrier movement, the mechanisms of pulse jitter and pulse drift are investigated. It is found that the pulse jitter is caused by time dispersion of the ionization process in the collector depletion region, while the pulse drift is due to the decrement of the diffusion coefficient Dn and the electron mobility µn, which are both temperature-dependent. Based on the microscopic theoretical study, some macroscopic improvements on the time base stability are made. Some parameters of the trigger pulse and the circuit (e.g., charging capacitance) are optimized experimentally. Consequently, we achieved a pulser with an amplitude of 1.8 kV, pulse jitter of 25 ps, pulse drift of 100 ps/min at a pulse repetition frequency (PRF) of 100 kHz. Additionally, a new parameter k, the product of the highest PRF f and the peak power Ep, is defined to evaluate the output power. With almost the same time base stability, the proposed pulser has a k of 6.48 GHz W, which is improved significantly. Finally, a synthesized pulser with an amplitude of 2.5 kV and highest PRF of 100 kHz is achieved.

Development of a TEM-cell-integrated CO2 incubator for cell-based transient electromagnetic field bioeffect study.

To facilitate the cell-based experiment for pulsed electromagnetic field biological effect study, a novel TEM-cell-integrated CO2 incubator was developed. The integrated experimental system could simultaneously meet the requirement of standard cell culture condition and the various Transient Electromagnetic Field (TEF) exposure, which made it possible to study the relationship between different electromagnetic pulse exposure and the cellular responses in a reliable way. During the research, a comparison experiment was carried out to evaluate the necessity of the integrated incubator system: firstly, two different types of cell lines, which are the human prostate cancer cell line (PC3) and the pancreatic ß cell line (MIN6) were chosen and exposed in the TEM-cell which located in the open area and the integrated system, respectively, with the same EFT radiation conditions; then, the cells' viability, the cellular ROS level and the mitochondrial membrane potential (MMP) were detected, respectively. The results showed that in the same parameter of the EFT radiation, the processes of the cells had a significant difference and even opposite in the incubator and open area, and all the results could be reproducible. The phenomenon indicated the stability of the TEM-cell-integrated CO2 incubator, and also demonstrated the necessity to strictly control the cell culture condition when carrying out the precise mechanism study of the TEF bioresponse at the cellular levels.

A portable ultrawideband electromagnetic radiator with a 1.4 MW/50 kHz solid-state subnanosecond pulser.

In this note, a portable ultrawideband (UWB) electromagnetic radiator is developed based on a transistorized pulser with the peak power of 1.4 MW, the rise time less than 150 ps, and the repetition frequency of 50 kHz. To generate high-amplitude pulses, a 100-stage Marx circuit with parallel connection of multiple transistors is proposed. To improve the pulse repetition rate, the parallel charging Marx circuit is adopted with ferrite beads connected in series between stages for high isolation of pulses. In order to radiate the UWB electromagnetic pulse directionally, a compact combined antenna array is fabricated and connected with the pulser via a coaxial feeding module. The effective potential of the UWB radiator reaches 10.5 kV with the band range (-10 dB) from 173 MHz to 2.32 GHz.

Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2-related factor 2 pathway.

AIMS: Leonurine has been shown to trigger antioxidant responses during ischemic stroke, and nuclear factor erythroid 2-related factor 2 (Nrf-2) imparts protective effects against oxidative injury. The present study has determined that leonurine prevents ischemic injury of brain tissues via Nrf-2 pathway activation. METHODS: Male ICR mice and Nrf-2-/- mice were subjected to permanent middle cerebral artery occlusion (pMCAO) and received leonurine treatment at 2 hours after pMCAO by intraperitoneal injection. Neurological deficit scores as well as infarct volume were assessed to determine the neuroprotective role of leonurine. Nrf-2 was investigated using Western blotting and real-time polymerase chain reaction (RT-PCR) analysis to elucidate the neuroprotective mechanism of leonurine. Commercial kits were employed to determine reactive oxygen species (ROS), superoxide (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), malonaldehyde (MDA), and glutathione (GSH). Vascular endothelial growth factor (VEGF) was evaluated by Western blotting and RT-PCR analysis, and VEGF was localized using immunofluorescence. RESULTS: The application of leonurine on ICR mice resulted in an improvement in neurological deficit scores and a reduction in infarct volume. Leonurine upregulated nuclear Nrf-2 protein and increased total Nrf-2 protein expression and mRNA levels. Leonurine regulated SOD, MDA, CAT, GSH, and GSH-Px, and it significantly inhibited ROS production in ICR mice. Leonurine improved VEGF expression and increased VEGF expression in neurons, astrocytes, and endothelial cells. However, leonurine had no obvious beneficial effects on Nrf-2-/- mice. CONCLUSIONS: Leonurine exerted neuroprotective effects, promoted antioxidant responses, and upregulated VEGF expression by activating the Nrf-2 pathway.