ABSTRACT
Objectives@#To evaluate the immunogenicity of @*Methods@#Protein extracts from @*Results@#Immunization with @*Conclusion@#This is the advanced study to investigate the immunogenicity of
Subject(s)
Animals , Female , Antibodies, Bacterial/immunology , Antigens, Bacterial/immunology , Bacterial Proteins/immunology , Cross Reactions , Cytokines/immunology , Genome, Bacterial , Immunoglobulin G/immunology , Immunoglobulin M/immunology , Macrophages/immunology , Mice, Inbred BALB C , Mycobacterium avium Complex/immunology , Mycobacterium tuberculosis/immunology , Tuberculosis Vaccines/administration & dosage , Whole Genome SequencingABSTRACT
Angiogenesis in atherosclerotic plaque plays a critical role in the mechanism of atherosclerotic physiopathology. Present consensus shows that angiogenesis in atherosclerotic plaque is mainly resulted in hypoxia, inflammation and some pro-angiogenic factors. The homeostasis in plaque, which is hypoxic and infiltrated by inflammatory cells, may lead to angiogenesis, increase the plaque instability and the incidence rate of vascular events. This article reviews the progression of pathogenetic mechanism, physiopathological significance, relevant detecting technique and corresponding therapeutic methods of Chinese and Western medicine of angiogenesis in atherosclerotic plaque, so as to provide more theoretical basis for atherosclerotic clinical treatment.