ABSTRACT
This study aims to enhance the durability, cost-effectiveness, and sustainability of recycled fine aggregate concrete (RFAC) subjected to the combined effects of wet-dry cycles and sulfate erosion. Dry-wet cycle tests were conducted in RFAC with different admixtures of biotite metakaolin (MK) and 15% fly ash (FA) mix (M) under 5% sulfate erosion environment. The effect of 0%, 30%, 60% and 90% recycled fine aggregate (RFA) replacement of natural fine aggregate on mass loss, cubic compressive strength, relative dynamic modulus test of RFAC, damage modeling and prediction of damage life of concrete were investigated. The results showed that the concrete cubic compressive strength and relative dynamic modulus were optimal for recycled concrete at 15% MK biotite dosing and 60% RFA substitution, and its maximum service life was accurately predicted to be about 578 cycles under 5% sulfate dry-wet cycling using Weibull function model. This study is pioneering in addressing the durability of RFAC under sulfate attack combined with wet-dry cycling, employing a novel approach of incorporating MK and FA into RFAC. The findings highlight the practical application potential for using MK and FA in RFAC to produce durable and sustainable construction materials, particularly in sulfate-exposed environments. This research addresses a critical challenge in the construction industry, providing valuable insights for developing more durable and eco-friendly construction materials and contributing to long-term sustainability goals.
ABSTRACT
Natural compounds like pterostilbene (PTE) have gained recognition for their various biological activities and potential health benefits. However, challenges related to bioavailability and limited clinical efficacy have prompted efforts to strengthen their therapeutic potential. To meet these challenges, we herein rationally designed and successfully synthesized a pharmaceutical phosphoramidite that allows for the programmable incorporation of PTE into oligonucleotides. The resultant aptamer-PTE conjugate can selectively bind to cancer cells, leading to a specific internalization and drug release. Moreover, compared with free PTE, the conjugate exhibits superior cytotoxicity in cancer cells. Specifically, in a zebrafish xenograft model, the nanomedicine effectively inhibits tumor growth and neovascularization, highlighting its potential for targeted antitumor therapy. This approach presents a promising avenue for harnessing the therapeutic potential of natural compounds via a nanomedicine solution.
Subject(s)
Nanomedicine , Neoplasms , Animals , Humans , Cell Line, Tumor , Neoplasms/drug therapy , Oligonucleotides , ZebrafishABSTRACT
In the title compound, C(17)H(18)N(2)O(3), the benzene rings form a dihedral angle of 3.34â (2)°. There is a strong intra-molecular O-Hâ¯N hydrogen bonds (which induces planarity of the structure). In the crystal, mol-ecules are linked by pairs of O-Hâ¯N hydrogen bonds, forming inversion dimers.
ABSTRACT
In the title complex, [Cu(C(14)H(14)NO(2))(2)], the discrete complex mol-ecules have crystallographic inversion symmetry. The slightly distorted square-planar coordination sphere of the Cu(II) atom comprises two phenolate O atoms and two oxime N atoms from two bidentate-chelate 2-[1-(eth-oxy-imino)-eth-yl]-1-naphtho-late O-ethyl oxime (L(-)) ligands [Cu-O = 1.8919â (17)â Å and Cu-N = 1.988â (2)â Å]. The two naphthalene ring systems in the mol-ecule are parallel, with a perpendicular inter-planar spacing of 1.473â (2)â Å, while each complex unit forms links to four other mol-ecules via inter-molecular methyl C-Hâ¯π inter-actions, giving an infinite cross-linked layered supra-molecular structure.