Comparing the cost-benefit probability of management based on early-stage and late-stage economic thresholds with that of seed treatment of Aphis glycines.

BACKGROUND: The current integrated pest management (IPM) curative strategy for soybean aphid, Aphis glycines Matsumura (Hemiptera: Aphididae), relies on responsive spraying foliar insecticides during the R1-R5 soybean stage when aphid abundance reaches the economic threshold (ET) of 250 aphids plant-1 (traditional IPM). By analyzing the relationship between aphid abundance and yield loss before the R1 stage, we developed an early-stage ET. We propose to spray foliar insecticides on plants colonized with aphids using the early-stage ET as a trigger (improved IPM), together with seed treatment to manage A. glycines and delay them exceeding the ET of 250 aphids plant-1 in the late stage for whole-field spraying (traditional IPM). Finally, we compared the cost-benefit probabilities of the three management approaches. RESULTS: The early-stage ET over all potential yields, market prices, and control costs was 64 aphids plant-1 , providing growers 7 days of preparation time to spray foliar insecticides before the economic injury level of 187 aphids plant-1 was reached. Improved IPM achieved the highest cost-benefit probabilities followed by traditional IPM, and the seed treatment achieved the lowest. However, in fields where the pressure from white grubs was high, the probability of achieving a positive net return with seed treatment was higher than that in other locations. CONCLUSION: Improved IPM based on early-stage ET of 64 aphids plant-1 was the most cost-effective of all the three approaches. Neonicotinoid seed treatment can be applied as an insurance strategy to supplement A. glycines IPM in Liaoning, China. © 2022 Society of Chemical Industry.

Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study.

BACKGROUND: Panic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cognitive model, PD patients' intrinsic and unconscious misappraisal strategies are the cause of panic attacks. However, no studies have yet been performed to explore the underlying neuromechanism of cognitive reappraisal that occur on an unconscious level in PD patients. METHODS: Twenty-six patients with PD and 25 healthy controls (HC) performed a fully-verified event-block design emotional regulation task aimed at investigating responses of implicit cognitive reappraisal during an fMRI scan. Participants passively viewed negatively valanced pictures that were beforehand neutrally, positively, or adversely portrayed in the task. RESULTS: Whole-brain analysis of fMRI data showed that PD patients exhibited less activation in the right dorsolateral prefrontal cortex (dlPFC) and right dorsomedial prefrontal cortex (dmPFC) compared to HC, but presented greater activation in parietal cortex when negative pictures were preceded by positive/neutral vs negative descriptions. Simultaneously, interactive effects of Group × Condition were observed in the right amygdala across both groups. Furthermore, activation in dlPFC and dmPFC was is negatively correlated to severity of anxiety and panic in PD when negative images were preceded by non-negative vs negative descriptions. CONCLUSIONS: Emotional dysregulation in PD is likely the result of deficient activation in dlPFC and dmPFC during implicit cognitive reappraisal, in line with impaired automatic top-down regulation. Correlations between severity of anxiety and panic attack and activation of right dlPFC and dmPFC suggest that the failure to engage prefrontal region during implicit cognitive reappraisal might be associated wtih the severity of anxiety and panic; such functional patterns might be the target of possible treatments.

Circulating Soluble ST2 Predicts All-Cause Mortality in Severe Heart Failure Patients with an Implantable Cardioverter Defibrillator.

BACKGROUND: Heart failure (HF) is the terminal stage of all cardiovascular events. Although implantable cardioverter defibrillator (ICD) therapies have reduced mortality among the high-risk HF population, it is necessary to determine whether certain factors can predict mortality even after cardiac device implantation. Growth stimulation expressed gene 2 (ST2) is an emerging biomarker for HF patient stratification in different clinical settings. AIMS: This study aimed to investigate the relationship between baseline soluble ST2 (sST2) levels in serum and the clinical outcomes of high-risk HF patients with device implantation. METHODS: Between January 2017 and August 2018, we prospectively recruited consecutive patients implanted with an ICD for heart failure, with LVEF ≤35% as recommended, and analyzed the basic characteristics, baseline serum sST2, and NT-proBNP levels, with at least 1-year follow-up. All-cause mortality was the primary endpoint. RESULTS: During a 643-day follow-up, all-cause mortality occurred in 16 of 150 patients (10.67%). Incidence of all-cause mortality increased significantly in patients with sST2 levels above 34.98846 ng/ml (16.00% vs. 5.33%, P = 0.034). After adjusting the model (age, gender, device implantation, prevention of sudden death, LVEDD, LVEF, WBC and CLBBB, hsTNT, etiology, and eGFR) and the model combined with NT-proBNP, the risk of all-cause death was increased by 2.5% and 1.9%, respectively, per ng/ml of sST2. The best sST2 cutoff for predicting all-cause death was 43.42671 ng/ml (area under the curve: 0.72, sensitive: 0.69, and specificity: 0.69). Compared to patients with sST2 levels below 43.42671 ng/ml, the risk of all-cause mortality was higher in those with values above the threshold (5.1% vs. 21.2%, P = 0.002). ST2 level ≥43.42671 ng/ml was an independent predictor of all-cause mortality (HR: 3.30 [95% CI 1.02-10.67]). Age (HR: 1.06 [95% CI: 1.01-1.12]) and increased NT-proBNP per 100 (HR: 1.02 [95% CI: 1.01-1.03]) were also associated with all-cause mortality in ICD patients. CONCLUSIONS: sST2 level was associated with risk of all-cause mortality, and a threshold of 43.43 ng/ml showed good distinguishing performance to predict all-cause mortality in patients with severe heart failure, recommended for ICD implantation. Patients with sST2 levels more than 43.42671 ng/ml even after ICD implantation should therefore be monitored carefully.

Multiple Neural Networks Malfunction in Primary Blepharospasm: An Independent Components Analysis.

Primary blepharospasm (BPS) is a focal dystonia characterized by involuntary blinking and eyelid spasms. The pathophysiology of BPS remains unclear. Several neuroimaging studies have suggested dysfunction of sensory processing and sensorimotor integration, but the results have been inconsistent. This study aimed to determine whether patients with BPS exhibit altered functional brain connectivity and to explore possible correlations between these networks and clinical variables. Twenty-five patients with BPS and 25 healthy controls were enrolled. We found that the patient group exhibited decreased connectivity within the sensory-motor network (SMN), which involved regions of the bilateral primary sensorimotor cortex, supplementary motor area (SMA), right premotor cortex, bilateral precuneus and left superior parietal cortex. Within the right fronto-parietal network, decreased connections were observed in the middle frontal gyrus, dorsal lateral prefrontal cortex and inferior frontal gyrus. Regarding the salience network (SN), increased connectivity was observed in the left superior frontal gyrus and middle frontal gyrus. These findings suggest the involvement of multiple neural networks in primary BPS.

Selection of key sequence-based features for prediction of essential genes in 31 diverse bacterial species.

Genes that are indispensable for survival are essential genes. Many features have been proposed for computational prediction of essential genes. In this paper, the least absolute shrinkage and selection operator method was used to screen key sequence-based features related to gene essentiality. To assess the effects, the selected features were used to predict the essential genes from 31 bacterial species based on a support vector machine classifier. For all 31 bacterial objects (21 Gram-negative objects and ten Gram-positive objects), the features in the three datasets were reduced from 57, 59, and 58, to 40, 37, and 38, respectively, without loss of prediction accuracy. Results showed that some features were redundant for gene essentiality, so could be eliminated from future analyses. The selected features contained more complex (or key) biological information for gene essentiality, and could be of use in related research projects, such as gene prediction, synthetic biology, and drug design.

Neural mechanisms of implicit cognitive reappraisal: Preceding descriptions alter emotional response to unpleasant images.

The importance of reappraising negative events to reduce negative emotional responses has been widely acknowledged. However, most neuroimaging studies have explored the neural mechanisms of deliberate and intentional reappraisal, while little is known about the neural correlates of reappraisal that occurs outside of one's awareness. Electrophysiological studies suggest that precedent neutral descriptions could implicitly reduce neural responses to unpleasant images. To investigate the neural mechanism underlying implicit reappraisal, functional magnetic resonance imaging was conducted on 25 participants while they passively viewed unpleasant images that were previously neutrally/positively or negatively described. Increased activity in prefrontal areas including the dorsolateral and dorsomedial prefrontal cortices, lateral orbitofrontal cortex, and temporal cortex, and decreased activation in the amygdala was observed-similar to the pattern reported in deliberate emotion regulation-when unpleasant images were preceded by neutral/positive versus negative descriptions. Functional connectivity analysis revealed significant negative couplings between prefrontal regions and the amygdala. These findings suggest that implicit reappraisal recruits prefrontal regions to change semantic representations in the temporal cortex, in turn modulating the emotional response of the amygdala.

Seasonal occurrence of Aphis glycines and physiological responses of soybean plants to its feeding.

The soybean aphid Aphis glycines Matsumura (Hemiptera: Aphididae) is an important pest of soybean in China. To monitor and manage this pest effectively it is necessary to understand its population dynamics and demographics, as well as the physiological responses of soybean plants to its feeding. In this study, using field surveying and suction-trap monitoring, we investigated the population dynamics of the soybean aphid in Xiuyan County, Liaoning Province in northeastern China during 2009-2012. The results indicated that the population dynamics of the soybean aphid followed a unimodal curve distribution, with the insect generally colonizing soybean fields from the middle of June to early July and the population reaching a peak between early July and early August. On the whole, soybean aphids occurred in suction-traps at least 2 weeks earlier than they were found in field surveys. A total of 72 alates were collected by suction-trapping over the 4 years, with the earliest alate captures occurring on 28 May in 2009, 2011, 2012 and 4 June in 2010. The life table parameters clearly showed that this aphid had a short doubling time (4.73 ± 0.21 days), and 7.36 ± 0.98 nymphs were produced by a soybean aphid adult during its lifetime (13.57 ± 0.30 days). Finally, biochemical assays indicated that the amount of malondialdehyde and the activities of four defense-related enzymes in soybean leaves significantly changed between 0 day and 7 days of aphid infestation. Polyphenol oxidase (PPO) and catalase (CAT) activities increased more dramatically after 1 day of aphid feeding. In addition, significantly higher levels of superoxide dismutase and CAT were found after aphid feeding for 7 days, whereas there was no significant change in the activities of peroxidase and PPO. Consequently, this study will be beneficial in determining the seasonal occurrence of the soybean aphid and selecting insect-resistant soybean varieties, and thus in developing a theoretical framework for appropriate management strategies.