Adaptive Memory of a Neuromorphic Transistor with Multi-Sensory Signal Fusion.

One of the ultimate goals of artificial intelligence is to achieve the capability of memory evolution and adaptability to changing environments, which is termed adaptive memory. To realize adaptive memory in artificial neuromorphic devices, artificial synapses with multi-sensing capability are required to collect and analyze various sensory cues from the external changing environments. However, due to the lack of platforms for mediating multiple sensory signals, most artificial synapses have been mainly limited to unimodal or bimodal sensory devices. Herein, we present a multi-modal artificial sensory synapse (MASS) based on an organic synapse to realize sensory fusion and adaptive memory. The MASS receives optical, electrical, and pressure information and in turn generates typical synaptic behaviors, mimicking the multi-sensory neurons in the brain. Sophisticated synaptic behaviors, such as Pavlovian dogs, writing/erasing, signal accumulation, and offset, were emulated to demonstrate the joint efforts of bimodal sensory cues. Moreover, associative memory can be formed in the device and be subsequently reshaped by signals from a third perception, mimicking modification of the memory and cognition when encountering a new environment. Our MASS provides a step toward next-generation artificial neural networks with an adaptive memory capability.

An Aqueous Electrolyte Gated Artificial Synapse with Synaptic Plasticity Selectively Mediated by Biomolecules.

The emulation of functions and behaviors of biological synapses using electronic devices has inspired the development of artificial neural networks (ANNs) in biomedical interfaces. Despite the achievements, artificial synapses that can be selectively responsive to non-electroactive biomolecules and directly operate in biological environments are still lacking. Herein, we report an artificial synapse based on organic electrochemical transistors and investigate the selective modulation of its synaptic plasticity by glucose. The enzymatic reaction between glucose and glucose oxidase results in long-term modulation of the channel conductance, mimicking selective binding of biomolecules to their receptors and consequent long-term modulation of the synaptic weight. Moreover, the device shows enhanced synaptic behaviors in the blood serum at a higher glucose concentration, which suggests its potential application in vivo as artificial neurons. This work provides a step towards the fabrication of ANNs with synaptic plasticity selectively mediated by biomolecules for neuro-prosthetics and human-machine interfaces.

Wearable Electronics Based on Stretchable Organic Semiconductors.

Wearable electronics are attracting increasing interest due to the emerging Internet of Things (IoT). Compared to their inorganic counterparts, stretchable organic semiconductors (SOSs) are promising candidates for wearable electronics due to their excellent properties, including light weight, stretchability, dissolubility, compatibility with flexible substrates, easy tuning of electrical properties, low cost, and low temperature solution processability for large-area printing. Considerable efforts have been dedicated to the fabrication of SOS-based wearable electronics and their potential applications in various areas, including chemical sensors, organic light emitting diodes (OLEDs), organic photodiodes (OPDs), and organic photovoltaics (OPVs), have been demonstrated. In this review, some recent advances of SOS-based wearable electronics based on the classification by device functionality and potential applications are presented. In addition, a conclusion and potential challenges for further development of SOS-based wearable electronics are also discussed.

Grain Size Effects in Mn-Modified 0.67BiFeO3-0.33BaTiO3 Ceramics.

Grain size can have significant effects on the properties of electroceramics for dielectric, piezoelectric, and ferroelectric applications. Here, we systematically investigate the effect of grain size on the structure and properties of Mn-modified 0.67BiFeO3-0.33BaTiO3 ceramics, an important lead-free piezoelectric ceramic that exhibits both a high piezoelectric coefficient and a high Curie point. Ceramics with average grain sizes ranging from 0.46 to 6.85 µm were prepared using conventional and spark plasma sintering. It was found that the morphotropic phase boundary compositions are composed of two polar structures, rhombohedral and tetragonal, with DC poling inducing an increase in the fraction of the rhombohedral phase. All ceramics show relaxor behavior and their freezing temperature moves to higher temperatures with increasing grain size, although their Burns temperature is independent of grain size. In fine-grained ceramics, which show pronounced relaxor behavior, significant grain size dependency is seen in dielectric, piezoelectric, and ferroelectric properties, which is attributed to the presence of single ferroelectric domains and high concentrations of polar nanoregions. In coarse-grained ceramics, a critical grain size of 2.83 µm yields the highest dielectric permittivity at room temperature, with the piezoelectric coefficient plateauing at this grain size, which can be attributed to the contribution of both polar nanoregions and high domain wall density.

Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices.

The ability to detect proteins through gating conductance by their unique surface electrostatic signature holds great potential for improving biosensing sensitivity and precision. Two challenges are: (1) defining the electrostatic surface of the incoming ligand protein presented to the conductive surface; (2) bridging the Debye gap to generate a measurable response. Herein, we report the construction of nanoscale protein-based sensing devices designed to present proteins in defined orientations; this allowed us to control the local electrostatic surface presented within the Debye length, and thus modulate the conductance gating effect upon binding incoming protein targets. Using a ß-lactamase binding protein (BLIP2) as the capture protein attached to carbon nanotube field effect transistors in different defined orientations. Device conductance had influence on binding TEM-1, an important ß-lactamase involved in antimicrobial resistance (AMR). Conductance increased or decreased depending on TEM-1 presenting either negative or positive local charge patches, demonstrating that local electrostatic properties, as opposed to protein net charge, act as the key driving force for electrostatic gating. This, in turn can, improve our ability to tune the gating of electrical biosensors toward optimized detection, including for AMR as outlined herein.

Tuning Electrostatic Gating of Semiconducting Carbon Nanotubes by Controlling Protein Orientation in Biosensing Devices.

The ability to detect proteins through gating conductance by their unique surface electrostatic signature holds great potential for improving biosensing sensitivity and precision. Two challenges are: (1) defining the electrostatic surface of the incoming ligand protein presented to the conductive surface; (2) bridging the Debye gap to generate a measurable response. Herein, we report the construction of nanoscale protein-based sensing devices designed to present proteins in defined orientations; this allowed us to control the local electrostatic surface presented within the Debye length, and thus modulate the conductance gating effect upon binding incoming protein targets. Using a ß-lactamase binding protein (BLIP2) as the capture protein attached to carbon nanotube field effect transistors in different defined orientations. Device conductance had influence on binding TEM-1, an important ß-lactamase involved in antimicrobial resistance (AMR). Conductance increased or decreased depending on TEM-1 presenting either negative or positive local charge patches, demonstrating that local electrostatic properties, as opposed to protein net charge, act as the key driving force for electrostatic gating. This, in turn can, improve our ability to tune the gating of electrical biosensors toward optimized detection, including for AMR as outlined herein.

Direct Synthesis of Multiplexed Metal-Nanowire-Based Devices by Using Carbon Nanotubes as Vector Templates.

We present the synthesis of metal nanowires in a multiplexed device configuration using single-walled carbon nanotubes (SWNTs) as nanoscale vector templates. The SWNT templates control the dimensionality of the wires, allowing precise control of their size, shape, and orientation; moreover, a solution-processable approach enables their linear deposition between specific electrode pairs in electronic devices. Electrical characterization demonstrated the successful fabrication of metal nanowire electronic devices, while multiscale characterization of the different fabrication steps revealed details of the structure and charge transfer between the material encapsulated and the carbon nanotube. Overall the strategy presented allows facile, low-cost, and direct synthesis of multiplexed metal nanowire devices for nanoelectronic applications.

Reconfigurable Carbon Nanotube Multiplexed Sensing Devices.

Here we report on the fabrication of reconfigurable and solution processable nanoscale biosensors with multisensing capability, based on single-walled carbon nanotubes (SWCNTs). Distinct DNA-wrapped (hence water-soluble) CNTs were immobilized from solution onto different prepatterned electrodes on the same chip, via a low-cost dielectrophoresis (DEP) methodology. The CNTs were functionalized with specific, and different, aptamer sequences that were employed as selective recognition elements for biomarkers indicative of stress and neuro-trauma conditions. Multiplexed detection of three different biomarkers was successfully performed, and real-time detection was achieved in serum down to physiologically relevant concentrations of 50 nM, 10 nM, and 500 pM for cortisol, dehydroepiandrosterone-sulfate (DHEAS), and neuropeptide Y (NPY), respectively. Additionally, the fabricated nanoscale devices were shown to be reconfigurable and reusable via a simple cleaning procedure. The general applicability of the strategy presented, and the facile device fabrication from aqueous solution, hold great potential for the development of the next generation of low power consumption portable diagnostic assays for the simultaneous monitoring of different health parameters.

[Impact of hydraulic retention time (HRT) in ABR on its operation performance and granular sludge characteristics when treating low-strength wastewater].

The impact of hydraulic retention time (HRT) in an anaerobic baffled reactor (ABR) on its operation performance and granular sludge characteristics was investigated through both testing its operation and analyzing the particle size distribution (PSD) and fractal dimensions of these sludge granules when treating low-strength wastewater. As HRT was gradually reduced from 24 h to 5 h, ABR had good performance on the organics removal and could reach about 90% for the COD removal, the VFA contents in ABR effluent and their pH values showed opposite trends. Most COD in wastewater was removed in the first two compartments of ABR during the running period of HRT from 24 h to 12 h, after that, the middle three compartments in ABR performed the most removal work. The MISS in latter compartments of ABR increased and the tendency of MLVSS/MISS ratios in the former three compartments were higher than that in the latter two ones appeared more and more remarkable along with the decrease of HRT. At HRT 24 h and 18 h, the granules grew bigger than before start-up,whose one-dimensional fractal dimension (D) decreased and two-dimensional fractal dimension (D2) increased, implying the smoother surface and more compact structure. As the HRT changed to 12 h and 8 h, the increasing D1 and decreasing D2 of granular sludge indicated its rougher surface and looser structure, and the bigger granules were formed with holes in their center. At HRT 5 h, smoother and more compact granules formed with smaller number median diameters of 0.72-0.82 mm than that at HRT 8 h. The looser granules were broken-up and some granules were discharged from ABR under the hydraulic disturbance and screening effect, at the same time, the growth of microorganism and their EPS (extracellular polymer substance) secretion could smooth the surface of the fragmentized granules. The fractal dimensions of granular sludge in the one-dimensional and two-dimensional topological spaces behaved inversely in each compartment of ABR at the same HRT, that is to say, the granular sludge along the ABR sequences became smoother on the surface meanwhile more compact structurally.