ABSTRACT
Background: To study the active ingredient and possible mechanism of Huisheng oral liquid in the treatment of lung cancer by network pharmacology. Methods: The active ingredient and drug targets of Huisheng oral liquid were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and Traditional Chinese Medicine Integrated Database (TCMID), and lung cancer targets were screened using the Gene Expression Omnibus (GEO) database. The drug targets of the effective components of Huisheng oral liquid were matched with disease targets and the obtained intersecting targets were imported into the Search Tool for the Retrieval of Interaction Gene/Proteins (STRING) database to construct a protein-protein interaction (PPI) network. R software and the Kyoto Encyclopedia of Genes and Genomes (KEGG) database were used for Gene Ontology (GO) and KEGG enrichment analyses, and Cytoscape software was used to construct a Huisheng oral liquid component target-lung cancer target network. The function and pathway of the therapeutic target of Huisheng oral liquid for lung cancer were analyzed. Results: A total of 1,376 differentially expressed genes (DEGs) of lung cancer were obtained, and 185 potential effective components of Huisheng oral liquid in the treatment of lung cancer were obtained, including quercetin, luteolin, kaempferol, and baicalein. There were 36 intersecting targets between Huisheng oral liquid and lung cancer, and the key targets for lung cancer treatment were CDKN1A, CCNB1, MDM2, CDK1, ErbB2, E2F1, EGFR, etc. Huisheng oral liquid mainly regulates the p53 signaling pathway. Conclusions: The mechanism of Huisheng oral liquid in the treatment of lung cancer is mainly reflected in regulating tumor cell apoptosis, inhibiting angiogenesis, and improving immunity.
ABSTRACT
We numerically studied gas high-harmonic generation in a two-color vortex laser field using the non-adiabatic Lewenstein model. Macroscopic responses were calculated by numerically solving the three-dimensional propagation equation in cylindrical coordinates. It was confirmed that unique high-harmonic signals with necklace-like shapes exhibit orbital angular momentum (OAM). The azimuthally distributed necklace harmonics exhibit periodic modulation as a function of laser frequency and topological charges of the driving field. Phase investigation showed that the OAM of the necklace harmonics is attributable to the tuning of the relative intensity of the two driving pulses. These findings provide a new dimension for high-harmonic manipulation in the vortex field. The two-color vortex field is the first scheme proposed for manipulating the intensity profile of high harmonics.
ABSTRACT
We present a theoretical investigation of the isolated extreme-ultraviolet (XUV) attosecond pulse propagating in the ionizing gas induced by a synchronized strong infrared (IR) laser, with the numerical solution of the nonadiabatic one-dimensional propagation model. Upon scanning the relative delay between the XUV and the IR pulse, it is found that the delay-dependent XUV transmission spectrogram exhibits the unique pattern that is controllable by the chirp of the XUV pulse. Furthermore, we demonstrate that this kind of spectrum modulation can be attributed to the term of the light energy loss involved in the propagation equation. The characteristics of the spectrum modulation dependent on the XUV chirp might provide an all-optical way for the reconstruction of the XUV spectral phase.