Ambient air pollution is associated with graft failure/death in pediatric liver transplant recipients.

Children exposed to disproportionately higher levels of air pollution experience worse health outcomes. In this population-based, observational registry study, we examine the association between air pollution and graft failure/death in children following liver transplantation (LT) in the US. We modeled the associations between air pollution (PM2.5) levels localized to the patient's ZIP code at the time of transplant and graft failure or death using Cox proportional-hazards models in pediatric LT recipients aged <19 years in the US from 2005-2015. In univariable analysis, high neighborhood PM2.5 was associated with a 56% increased hazard of graft failure/death (HR: 1.56; 95% CI: 1.32, 1.83; P < .001). In multivariable analysis, high neighborhood PM2.5 was associated with a 54% increased risk of graft failure/death (HR: 1.54; 95% CI: 1.29, 1.83; P < .001) after adjusting for race as a proxy for racism, insurance status, rurality, and neighborhood socioeconomic deprivation. Children living in high air pollution neighborhoods have an increased risk of graft failure and death posttransplant, even after controlling for sociodemographic variables. Our findings add further evidence that air pollution contributes to adverse health outcomes for children posttransplant and lay the groundwork for future studies to evaluate underlying mechanisms linking PM2.5 to adverse LT outcomes.

Outcomes of Patients With Negative Cervical Imaging but Persistent Neck Tenderness Discharged With a Rigid Collar After Trauma.

Introduction It is not uncommon for patients with persistent neck pain after trauma despite negative cervical imaging to be discharged with a rigid collar. Protocols for these patients vary widely. Few studies have evaluated clinical outcomes after discharge. No studies have evaluated the patient's experience in a cervical collar after discharge. Methods We evaluated adults with blunt trauma and negative cervical spine imaging who were discharged in a rigid cervical collar. Over a 19-month period, 45 patients were available for analyses. The primary outcome was any identified missed injuries after discharge. Secondary outcomes were the incidence of patients self-clearing from their collars and complications related to wearing a collar. Results There were no missed traumatic injuries on follow-up imaging. Twenty of 45 patients cleared themselves from the collar without a physician order. Twenty-four patients had their collars removed by a provider in the clinic between 1-84 days after injury. One patient removed the collar after being advised by a chiropractor. More than half of patients reported one or more complications from wearing the cervical collar including pain, skin irritation, problems sleeping, difficulty talking or swallowing. Conclusions Collar complications are frequent. Follow-up imaging did not change outpatient management. Our data suggests against the practice of discharging trauma patients home in a cervical collar with negative imaging and no focal neurologic deficit.