1.
Chem Commun (Camb)
; 58(1): 56-59, 2021 Dec 21.
Article
in English
| MEDLINE
| ID: mdl-34897335
ABSTRACT
The oxidative damage of DNA is associated with aging and the development of various diseases. Although nucleoside-derived radicals play an important role in DNA oxidation, their analysis methods are limited. Herein, we propose a fluorometric detection and structural analysis of radicals on the surface of oxidatively damaged DNA using a profluorescent nitroxide probe combined with liquid chromatography-fluorometry and high-resolution tandem mass spectrometry.