1.
Org Lett
; 22(21): 8446-8450, 2020 Nov 06.
Article
in English
| MEDLINE
| ID: mdl-33052692
ABSTRACT
A nickel(II)-catalyzed oxygen transfer reaction of dibenzylideneacetone-derived N-vinyl-α,ß-unsaturated nitrones has been identified for the preparation of polysubstituted 2-(pyridin-2-yl)ethanols in good yields with high atom economy. The scope of the method is described, and mechanistic experiments are discussed. The reaction was easily performed at gram scales, and pyrido[2,3-c]carbazole was obtained in moderate yield over three steps.