ABSTRACT
BACKGROUND: This study aims to explore the effectiveness of vitamin D for the management of adult patients with gingivitis. METHODS: We will perform a comprehensive search from the following electronic databases: Cochrane Library, PUBMED, EMBASE, AMED, CINAHL, WANGFANG, VIP, CBM, and China National Knowledge Infrastructure. All databases will be searched from their inceptions to the present without language limitation. We will also search for unpublished data to avoid missing more potential studies. Two authors will carry out study selection, data extraction, and methodological quality evaluation, respectively. RevMan 5.3 software will be utilized for statistical analysis. RESULTS: This study will summarize the up-to-date evidence about the anti-inflammatory effect of vitamin D for the management of adult patients with gingivitis through assessing modified gingival, gingival bleeding indices, inflammatory factors, plaque, quality of life, and any adverse events. CONCLUSION: This study may provide helpful evidence of vitamin D for the management of adult patients with gingivitis for clinical practice. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019156561.
Subject(s)
Gingivitis/drug therapy , Gingivitis/psychology , Vitamin D/therapeutic use , Adult , China/epidemiology , Gingivitis/pathology , Humans , Quality of Life , Randomized Controlled Trials as Topic , Treatment Outcome , Vitamin D/adverse effectsABSTRACT
BACKGROUND: Cisplatin is often used for the treatment of oral cancer (OC). However, there are inconsistent results. Thus, this study plans to systematically assess the clinical efficacy and safety of cisplatin for adult patients with OC. METHODS: We will search for PUBMED, EMBASE, Cochrane Library, AMED, Cumulative Index to Nursing and Allied Health Literature, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. All of them will be searched from the construction of each database up to the present with no restrictions of language and publication status. The data analysis will be conducted using RevMan 5.3 software to assess the efficacy and safety of cisplatin for adult patients with OC. RESULTS: This study will summarize the most recent high-quality evidence and will provide helpful information about the efficacy and safety of cisplatin for adult patients with OC. CONCLUSION: The findings of this study will provide convinced evidence of cisplatin for adult patients with OC, and provide recommendations for clinical practice. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019156558.
