ABSTRACT
Discovery of novel topological agents against Oncomelania hupensis snails and cercariae remains a significant challenge in current Schistosomiasis control. A pseudo-ring formed from salicylanilide by an intramolecular hydrogen bond led to the discovery of 3-substituted quinazolinone derivatives which showed a potent molluscicidal and cercaricidal activities.
Subject(s)
Cercaria/drug effects , Molluscacides/pharmacology , Quinazolinones/pharmacology , Snails/drug effects , Animals , Drug Discovery , Molluscacides/chemistry , Quinazolinones/chemistryABSTRACT
The title compound, C(15)H(13)Br(4)NO(4), was obtained via radical bromination reaction of ethyl 6,7-dimeth-oxy-2-methyl-quinoline-3-carboxyl-ate and N-bromo-succinimide (NBS) in the presence of benzoyl peroxide (BPO) under photocatalytic conditions. The quinoline ring system is approximately planar with a maximum deviation from the mean plane of 0.035â (1)â Å. The dihedral angle between the six-membered rings is 2.33â (2)°. The meth-oxy O atoms of the two neighboring meth-oxy groups are in-plane while their methyl C atoms are located on either side of the quinolyl ring plane at distances of -1.207â (1) and 1.223â (1)â Å.
ABSTRACT
In the title compound, C(18)H(21)N(3)O(2)·H(2)O, the fused-ring system is approximately planar [maximum atomic deviation = 0.028â (3)â Å]; the morpholine ring displays a chair conformation. The crystal packing is stabilized by classical inter-molecular O-Hâ¯O and O-Hâ¯N hydrogen bonds and weak C-Hâ¯O hydrogen bonds between the organic mol-ecules and the water mol-ecules.
ABSTRACT
Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The analysis of structure-activity relationships suggested that the introduction of allenic moiety could generate or enhance cytotoxicity of these phenol compounds.