Factors Influencing Preventive Behavior of COVID-19 among Nursing Students in South Korea.

We aimed to identify factors influencing the preventive behavior of COVID-19 among nursing students. A survey was conducted through an online questionnaire in December 2021 for students in the department of nursing at a university located in C city. An online questionnaire was distributed to 189 nursing students who voluntarily agreed to participate in the study, and data from 179 of them were used for the final analysis. The research tools used were COVID-19 stress scale for Korean people, COVID-19 risk-perception scale, self-efficacy scale, and COVID-19 prevention behavior scale. Data were analyzed by descriptive statistics, t-test, analysis of variance, Mann-Whitney and Kruskal-Wallis test, as well as Spearman correlation coefficient and multiple linear regression with SPSS 23.0 program. Factors significantly influencing the preventive behavior of COVID-19 were self-efficacy (ß = 0.53, p < 0.001) and COVID-19 stress (ß = 0.25, p = 0.001). The explanatory power of related variables was 45.0%. We found that self-efficacy and COVID-19 stress had a significant effect on the preventive behavior of nursing students. Therefore, to promote the preventive behavior of COVID-19, it is necessary to improve the self-efficacy of nursing students and manage COVID-19 stress well.

Predicting Posttraumatic Growth among Firefighters: The Role of Deliberate Rumination and Problem-Focused Coping.

Exposure to work-related traumatic incidents in firefighters may result in positive psychological changes which are termed "posttraumatic growth". This study aimed to construct structure equation modeling based on the model of posttraumatic growth in firefighters. Methods: A total of 226 firefighters who had experienced a work-related traumatic incident participated. The participants from three municipal fire departments and seven fire stations completed an anonymous survey asking about extraversion, optimism, calling in the workplace, problem-focused coping, deliberate rumination, and posttraumatic growth. The model fit indices were suitable for the recommended level. Seven of the 11 paths established in the initial hypothetical model were identified. The variables of deliberate rumination, problem-focused coping, and extraversion had a significant effect on the posttraumatic growth of firefighters, with an explanatory power of 38.7%. The findings show that it is important to develop strategies to enhance deliberate rumination and problem-focused coping for firefighters after work-related traumatic events.

Exploring the Relationships between Posttraumatic Growth, Wisdom, and Quality of Life in Older Cancer Survivors.

Objective: The number of older cancer survivors is steadily rising with a growing aging population, and a great interest in evaluating the quality of life is emerged. Although understanding how to improve the quality of life in older cancer survivors is critical as the number of older survivors continues to grow in communities, little is known about empirical evidence regarding predictors of the quality of life in older cancer survivors. This study aimed to examine relationships between posttraumatic growth, wisdom, and quality of life in older cancer survivors. Methods: A convenience sample of older cancer survivors after completing cancer treatments (n=121) participated from one public health center, and they filled out self-report questionnaires on measures of posttraumatic growth, wisdom, and quality of life. Results: As results of multiple regression analysis, the most significant factor on each domain of the quality of life has shown that higher levels of subjective economic status were associated with significant improvement of four domains of quality of life, and wisdom and posttraumatic growth were associated with significant improvement in social/family well-being. Conclusion: This study highlights predictors of each domain of quality of life that subjective economic status, posttraumatic growth and wisdom significantly affected the quality of life in older cancer survivors. Findings indicate that psychological interventions need to be developed and implemented for older cancer survivors to prevent long-term effects of cancer and to increase their quality of life. For improving their quality of life, primary care providers or community health professionals need to develop tailored interventions, such as home-based cancer survivorship programs.

The Effects of a Mobile Wellness Intervention with Fitbit Use and Goal Setting for Workers.

Background and Introduction: There is strong evidence that worksite wellness programs can significantly improve the health profile of participating workers. To date, little is known about research on the effects of mobile wellness interventions in worksite settings. Furthermore, no studies have been conducted to evaluate mobile wellness interventions with activity trackers and tailoring strategies for physically inactive workers in manufacturing companies. This study aimed to examine the effects of a mobile wellness intervention with Fitbit and goal setting using brief counseling and text messaging among workers. Materials and Methods: A total of 79 (n = 79) workers from large manufacturing companies were allocated into an experimental group (n = 41) and a control group (n = 38). All participants were asked to wear an activity tracker (Fitbit Charger HR) during all waking hours for 5 weekdays. Participants in the experimental group received Fitbit, daily motivational text messaging, and biweekly counseling with a specifically designed workbook for 12 weeks, whereas Fitbit was only provided to the control group. Results: At the 12-week measurement, there were significant differences between the experimental group and control group on wellness (p < 0.001), physical activity behavior (p < 0.001), daily walking steps (p < 0.001), and physical activity self-efficacy (p < 0.001). Discussion and Conclusions: Although Fitbit facilitates an individual's activities by providing information about daily steps, the tracker itself, without additional goal-setting techniques, may be insufficient to encourage behavior change. These findings indicate that the mobile wellness intervention with Fitbit and goal setting using brief counseling and tailored text messaging is more effective for physically inactive workers.

Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus.

Basal ganglia (BG) circuits orchestrate complex motor behaviors predominantly via inhibitory synaptic outputs. Although these inhibitory BG outputs are known to reduce the excitability of postsynaptic target neurons, precisely how this change impairs motor performance remains poorly understood. Here, we show that optogenetic photostimulation of inhibitory BG inputs from the globus pallidus induces a surge of action potentials in the ventrolateral thalamic (VL) neurons and muscle contractions during the post-inhibitory period. Reduction of the neuronal population with this post-inhibitory rebound firing by knockout of T-type Ca2+ channels or photoinhibition abolishes multiple motor responses induced by the inhibitory BG input. In a low dopamine state, the number of VL neurons showing post-inhibitory firing increases, while reducing the number of active VL neurons via photoinhibition of BG input, effectively prevents Parkinson disease (PD)-like motor symptoms. Thus, BG inhibitory input generates excitatory motor signals in the thalamus and, in excess, promotes PD-like motor abnormalities. VIDEO ABSTRACT.

A murine model for human sepiapterin-reductase deficiency.

Tetrahydrobiopterin (BH(4)) is an essential cofactor for several enzymes, including all three forms of nitric oxide synthases, the three aromatic hydroxylases, and glyceryl-ether mono-oxygenase. A proper level of BH(4) is, therefore, necessary for the metabolism of phenylalanine and the production of nitric oxide, catecholamines, and serotonin. BH(4) deficiency has been shown to be closely associated with diverse neurological psychiatric disorders. Sepiapterin reductase (SPR) is an enzyme that catalyzes the final step of BH(4) biosynthesis. Whereas the number of cases of neuropsychological disorders resulting from deficiencies of other catalytic enzymes involved in BH(4) biosynthesis and metabolism has been increasing, only a handful of cases of SPR deficiency have been reported, and the role of SPR in BH(4) biosynthesis in vivo has been poorly understood. Here, we report that mice deficient in the Spr gene (Spr(-/-)) display disturbed pterin profiles and greatly diminished levels of dopamine, norepinephrine, and serotonin, indicating that SPR is essential for homeostasis of BH(4) and for the normal functions of BH(4)-dependent enzymes. The Spr(-/-) mice exhibit phenylketonuria, dwarfism, and impaired body movement. Oral supplementation of BH(4) and neurotransmitter precursors completely rescued dwarfism and phenylalanine metabolism. The biochemical and behavioral characteristics of Spr(-/-) mice share striking similarities with the symptoms observed in SPR-deficient patients. This Spr mutant strain of mice will be an invaluable resource to elucidate many important issues regarding SPR and BH(4) deficiencies.