Correlation between perioperative new onset atrial fibrillation and prognosis of colorectal cancer / 中华普通外科杂志

Objective:To investigate the correlation between perioperative new onset atrial fibrillation and the prognosis of colorectal cancer.Methods:This study involved 180 colorectal cancer patients undgoing radical resection at the Department of Gastrointestinal Surgery, Longyan First Hospital from Jan 2014 to Jan 2015. Among them, 47cases suffered from perioperative new onset atrial fibrillation.Results:The perioperative new onset atrial fibrillation group had a higher mean age and a higher mean postoperative C-reactive protein level than the control group ( t=-3.080, P=0.002; t=-2.184, P=0.030). Hence these patients had a longer hospital stay ( t=-5.072, P=0.001; t=-2.577, P=0.011). Multivariate analysis showed that postoperative new onset atrial fibrillation, high postoperative mean C-reactive protein level, poor tumor differenciation and late tumor stage were independent risk factors for the prognosis of colorectal cancer ( HR=1.835, P=0.018; HR=1.008 P=0.017; HR=1.950 P=0.046; HR=1.300, P=0.047). The median survival time of perioperative new onset atrial fibrillation group and control group were 59.05 months and 63.23 months, respectively ( P=0.005). Conclusions:Colorectal cancer patients suffering from perioperative new onset atrial fibrillation were more common among advanced age and high postoperative mean C-reactive protein level with higher all-cause mortality.

Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses

Viruses are the major aetiological agents of acute and chronic severe human diseases that place a tremendous burden on global public health and economy; however, for most viruses, effective prophylactics and therapeutics are lacking, in particular, broad-spectrum antiviral agents. Herein, we identified 2 secreted bacterial lipases from a Chromobacterium bacterium, named Chromobacterium antiviral effector-1 (CbAE-1) and CbAE-2, with a broad-spectrum virucidal activity against dengue virus (DENV), Zika virus (ZIKV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human immunodeficiency virus (HIV) and herpes simplex virus (HSV). The CbAEs potently blocked viral infection in the extracellular milieu through their lipase activity. Mechanistic studies showed that this lipase activity directly disrupted the viral envelope structure, thus inactivating infectivity. A mutation of CbAE-1 in its lipase motif fully abrogated the virucidal ability. Furthermore, CbAE-2 presented low toxicity in vivo and in vitro, highlighting its potential as a broad-spectrum antiviral drug.

The predictive factors for postoperative intra-abdominal septic complications after intestinal resection in patients with Crohn's Disease / 中华普通外科杂志

Objective To investigate the predictive factors for postoperative intra-abdominal septic complications (IASCs) after intestinal resection in patients with Crohn's Disease (CD).Methods Clinical data from patients who underwent intestinal resection for CD at Sir Run Run Shaw Hospital between June 2011 and July 2016 were retrospectively analysed.The patients were divided into IASCs group and non-IASCs groups by whether suffering from postoperative IASCs.Univariate analysis and multivariate logistic regression analysis were performed to identify the predictive factors for postoperative IASCs,and the receiver operating characteristic curve (ROC) was used to analyse the diagnostic value of the results.Results Among one hundred and seventy-three patients who underwent intestinal resection for CD,15(8.7％) patients experienced postoperative IASCs.The results of univariate and multivariate analysis showed that preoperative CRP ≥ 10 mg/L (OR =4.920,95％ CI:1.137-21.287,P =0.033) was an independent trisk factor for postoperative IASCs,and the laparoscopic surgery (OR =0.070,95％ CI:0.007-0.701,P =0.024) was the independent protective factor for postoperative IASCs.By analyzing ROC curve,preoperative CRP level had the diagnostic value of predicting the postoperative IASCs.The areas under the ROC curves of preoperative CRP for postoperative IASCs were 0.729 with an optimal diagnostic cut-off value of 10.75 mg/L,and with sensitivity of 80.0％ and a specificity of 67.1％.Conclusions Preoperative CRP level is an independent risk factor for postoperative IASCs,and laparoscopic surgery is an independent protective factor for IASCs.