A Deep Reinforcement Learning Strategy for Surrounding Vehicles-Based Lane-Keeping Control.

As autonomous vehicles (AVs) are advancing to higher levels of autonomy and performance, the associated technologies are becoming increasingly diverse. Lane-keeping systems (LKS), corresponding to a key functionality of AVs, considerably enhance driver convenience. With drivers increasingly relying on autonomous driving technologies, the importance of safety features, such as fail-safe mechanisms in the event of sensor failures, has gained prominence. Therefore, this paper proposes a reinforcement learning (RL) control method for lane-keeping, which uses surrounding object information derived through LiDAR sensors instead of camera sensors for LKS. This approach uses surrounding vehicle and object information as observations for the RL framework to maintain the vehicle's current lane. The learning environment is established by integrating simulation tools, such as IPG CarMaker, which incorporates vehicle dynamics, and MATLAB Simulink for data analysis and RL model creation. To further validate the applicability of the LiDAR sensor data in real-world settings, Gaussian noise is introduced in the virtual simulation environment to mimic sensor noise in actual operational conditions.

Automated Laser-Fiber Coupling Module for Optical-Resolution Photoacoustic Microscopy.

Photoacoustic imaging has emerged as a promising biomedical imaging technique that enables visualization of the optical absorption characteristics of biological tissues in vivo. Among the different photoacoustic imaging system configurations, optical-resolution photoacoustic microscopy stands out by providing high spatial resolution using a tightly focused laser beam, which is typically transmitted through optical fibers. Achieving high-quality images depends significantly on optical fluence, which is directly proportional to the signal-to-noise ratio. Hence, optimizing the laser-fiber coupling is critical. Conventional coupling systems require manual adjustment of the optical path to direct the laser beam into the fiber, which is a repetitive and time-consuming process. In this study, we propose an automated laser-fiber coupling module that optimizes laser delivery and minimizes the need for manual intervention. By incorporating a motor-mounted mirror holder and proportional derivative control, we successfully achieved efficient and robust laser delivery. The performance of the proposed system was evaluated using a leaf-skeleton phantom in vitro and a human finger in vivo, resulting in high-quality photoacoustic images. This innovation has the potential to significantly enhance the quality and efficiency of optical-resolution photoacoustic microscopy.

TransNet: Transformer-Based Point Cloud Sampling Network.

As interest in point cloud processing has gradually increased in the industry, point cloud sampling techniques have been researched to improve deep learning networks. As many conventional models use point clouds directly, the consideration of computational complexity has become critical for practicality. One of the representative ways to decrease computations is downsampling, which also affects the performance in terms of precision. Existing classic sampling methods have adopted a standardized way regardless of the task-model property in learning. However, this limits the improvement of the point cloud sampling network's performance. That is, the performance of such task-agnostic methods is too low when the sampling ratio is high. Therefore, this paper proposes a novel downsampling model based on the transformer-based point cloud sampling network (TransNet) to efficiently perform downsampling tasks. The proposed TransNet utilizes self-attention and fully connected layers to extract meaningful features from input sequences and perform downsampling. By introducing attention techniques into downsampling, the proposed network can learn about the relationships between point clouds and generate a task-oriented sampling methodology. The proposed TransNet outperforms several state-of-the-art models in terms of accuracy. It has a particular advantage in generating points from sparse data when the sampling ratio is high. We expect that our approach can provide a promising solution for downsampling tasks in various point cloud applications.

C2RL: Convolutional-Contrastive Learning for Reinforcement Learning Based on Self-Pretraining for Strong Augmentation.

Reinforcement learning agents that have not been seen during training must be robust in test environments. However, the generalization problem is challenging to solve in reinforcement learning using high-dimensional images as the input. The addition of a self-supervised learning framework with data augmentation in the reinforcement learning architecture can promote generalization to a certain extent. However, excessively large changes in the input images may disturb reinforcement learning. Therefore, we propose a contrastive learning method that can help manage the trade-off relationship between the performance of reinforcement learning and auxiliary tasks against the data augmentation strength. In this framework, strong augmentation does not disturb reinforcement learning and instead maximizes the auxiliary effect for generalization. Results of experiments on the DeepMind Control suite demonstrate that the proposed method effectively uses strong data augmentation and achieves a higher generalization than the existing methods.

An Enhanced Affine Projection Algorithm Based on the Adjustment of Input-Vector Number.

An enhanced affine projection algorithm (APA) is proposed to improve the filter performance in aspects of convergence rate and steady-state estimation error, since the adjustment of the input-vector number can be an effective way to increase the convergence rate and to decrease the steady-state estimation error at the same time. In this proposed algorithm, the input-vector number of APA is adjusted reasonably at every iteration by comparing the averages of the accumulated squared errors. Although the conventional APA has the constraint that the input-vector number should be integer, the proposed APA relaxes that integer-constraint through a pseudo-fractional method. Since the input-vector number can be updated at every iteration more precisely based on the pseudo-fractional method, the filter performance of the proposed APA can be improved. According to our simulation results, it is demonstrated that the proposed APA has a smaller steady-state estimation error compared to the existing APA-type filters in various scenarios.

A Variable-Sampling Time Model Predictive Control Algorithm for Improving Path-Tracking Performance of a Vehicle.

This paper proposes a novel model predictive control (MPC) algorithm that increases the path tracking performance according to the control input. The proposed algorithm reduces the path tracking errors of MPC by updating the sampling time of the next step according to the control inputs (i.e., the lateral velocity and front steering angle) calculated in each step of the MPC algorithm. The scenarios of a mixture of straight and curved driving paths were constructed, and the optimal control input was calculated in each step. In the experiment, a scenario was created with the Automated Driving Toolbox of MATLAB, and the path-following performance characteristics and computation times of the existing and proposed MPC algorithms were verified and compared with simulations. The results prove that the proposed MPC algorithm has improved path-following performance compared to those of the existing MPC algorithm.

Peroxiredoxin 5 promotes the epithelial-mesenchymal transition in colon cancer.

Globally, colorectal cancer (CRC) is common cause of cancer-related deaths. The high mortality rate of patients with colon cancer is due to cancer cell invasion and metastasis. Initiation of the epithelial-to-mesenchymal transition (EMT) is essential for the tumorigenesis. Peroxiredoinxs (PRX1-6) have been reported to be overexpressed in various tumor tissues, and involved to be responsible for tumor progression. However, the exact role of PRX5 in colon cancer remains to be investigated enhancing proliferation and promoting EMT properties. In this study, we constructed stably overexpressing PRX5 and suppressed PRX5 expression in CRC cells. Our results revealed that PRX5 overexpression significantly enhanced CRC cell proliferation, migration, and invasion. On the other hand, PRX5 suppression markedly inhibited these EMT properties. PRX5 was also demonstrated to regulate the expression of two hallmark EMT proteins, E-cadherin and Vimentin, and the EMT-inducing transcription factors, Snail and Slug. Moreover, in the xenograft mouse model, showed that PRX5 overexpression enhances tumor growth of CRC cells. Thus, our findings first provide evidence in CRC that PRX5 promotes EMT properties by inducing the expression of EMT-inducing transcription factors. Therefore, PRX5 can be used as a predictive biomarker and serves as a putative therapeutic target for the development of clinical treatments for human CRC.

The effect of Monkey Chair and Band exercise system on shoulder range of motion and pain in post-stroke patients with hemiplegia.

[Purpose] A simple rehabilitation device system for strengthening upper limb muscles in hemiplegic patients was developed. This system, which stimulates active exercise while accounting for intensity, time, and frequency, was examined in the present pilot study. [Subjects and Methods] Patients had shoulder pain and limited shoulder movement. Changes in range of motion (ROM) and scores of a visual analog scale (VAS) for pain were evaluated in the experimental and control groups every four weeks for twelve weeks. The modified motor assessment scale (MMAS) was used before and after experiments. [Results] Significant differences between experimental times in ROM for shoulder flexion, abduction, and adduction on the paralyzed side were observed in the experimental group at every time point. Pain VAS scores in the experimental group improved progressively and significantly with time, indicating a consistently increasing effect of exercise. There were significant differences between the MMAS scores before and after completion of the program in the experimental group. [Conclusion] Muscle strengthening is important in hemiplegic patients, and active exercise was more efficient than passive exercise in this regard. Rehabilitation with the Monkey Chair and Band system may represent an efficient and important tool in upper limb training and comprehensive modern rehabilitation therapy.