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1.
Direct Extension of IgG4-Related Periarteritis of the Coronary Artery to the Adjacent Myocardium Demonstrated Using Dual-Energy Cardiac Computed Tomography.
Yoshino, Yuichi; Goda, Ayumi; Shimizu, Yuta; Mohri, Takato; Takeuchi, Shinsuke; Koyama, Kohei; Machida, Haruhiko; Yokoyama, Kenichi; Soejima, Kyoko; Kohno, Takashi.
Circ J ; 88(3): 434, 2024 Feb 22.
Article in English | MEDLINE | ID: mdl-38199252

Subject(s)
Arteritis , Coronary Vessels , Humans , Coronary Vessels/diagnostic imaging , Immunoglobulin G , Heart , Arteritis/diagnostic imaging , Tomography, X-Ray Computed/methods , Myocardium
2.
High-throughput screening of improved protease inhibitors using a yeast cell surface display system and a yeast cell chip.
Aoki, Wataru; Yoshino, Yuichi; Morisaka, Hironobu; Tsunetomo, Keiji; Koyo, Hirotaka; Kamiya, Shinji; Kawata, Noriyuki; Kuroda, Kouichi; Ueda, Mitsuyoshi.
J Biosci Bioeng ; 111(1): 16-8, 2011 Jan.
Article in English | MEDLINE | ID: mdl-20832357

ABSTRACT

Protease-targeted inhibitors have been promising pharmaceuticals. Here, we combined a yeast cell surface display system with a yeast cell chip for the high-throughput screening of protease inhibitors, and succeeded in improving the activity of a protease inhibitor.


Subject(s)
High-Throughput Screening Assays/methods , Protease Inhibitors/pharmacology , Drug Evaluation, Preclinical , Immunoglobulin Light Chains/chemistry , Metalloendopeptidases/antagonists & inhibitors , Recombinant Fusion Proteins/pharmacology , Saccharomyces cerevisiae/drug effects , Saccharomyces cerevisiae/metabolism
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