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J Nat Prod ; 76(10): 1872-80, 2013 Oct 25.
Article in English | MEDLINE | ID: mdl-24094143

ABSTRACT

Twenty new mexicanolide-type limonoids, namely, trichinenlides A-T (1-20), and 11 known analogues were isolated from the leaves and twigs of Trichilia sinensis. Trichinenlides B (2) and C (3) and heytrijunolide D exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 2.85, 1.88, and 3.33 µM, respectively.


Subject(s)
Drugs, Chinese Herbal/isolation & purification , Limonins/isolation & purification , Meliaceae/chemistry , Animals , Drugs, Chinese Herbal/chemistry , Drugs, Chinese Herbal/pharmacology , Inhibitory Concentration 50 , Limonins/chemistry , Limonins/pharmacology , Lipopolysaccharides/pharmacology , Macrophages/drug effects , Mice , Molecular Structure , Nitric Oxide/biosynthesis , Nuclear Magnetic Resonance, Biomolecular , Plant Leaves/chemistry
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