ABSTRACT
Strain FIM06054 was isolated from a marine sponge sample collected from the East China Sea and was characterised as a strain of Verrucosispora genus on the basis of its 16S rRNA gene sequence. One new compound, FW054-1 (1), together with a known aminofuran compound proximicin A (2), was isolated from the culture broth of Verrucosispora sp. FIM06054. Their structures were elucidated on the basis of spectral analysis. 1 and 2 showed antiproliferative activity against several human tumour cell lines.
Subject(s)
Antineoplastic Agents/isolation & purification , Antineoplastic Agents/pharmacology , Micromonosporaceae/chemistry , Netropsin/analogs & derivatives , Porifera/chemistry , Ribose/analogs & derivatives , Ribose/isolation & purification , Ribose/pharmacology , Animals , Antineoplastic Agents/chemistry , Drug Screening Assays, Antitumor , Humans , Marine Biology , Netropsin/chemistry , Netropsin/isolation & purification , Netropsin/pharmacology , Nuclear Magnetic Resonance, Biomolecular , RNA, Ribosomal, 16S/genetics , Ribose/chemistryABSTRACT
A new 20-membered macrolide named as levantilide C was isolated from the Micromonospora strain FIM07-0019 recovered from shallow coastal waters near the island of Chiloe, Chile. The chemical structure of levantilide C was elucidated on the basis of one- and two-dimensional NMR analysis. Two known indole derivatives were also isolated from this strain. Levantilide C exhibited moderate antiproliferative activity against several tumour cell lines.