COVID-19 infection leading to acute pustular dermatoses.

Viral infections, including SARS-CoV-2, the virus that causes COVID-19 infection, have been implicated in the development of pustular dermatoses, including generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP). We performed a literature review of existing cases of GPP and AGEP associated with COVID-19 infection and/or treatment reported over a period of 12 months. We summarize the clinical characteristics of these cases and report an additional six new cases of GPP and AGEP. Seven patients with COVID-19 infection were diagnosed with new-onset or exacerbated GPP, and 33 patients were diagnosed with AGEP. In 55% of the cases, no concomitant potential culprit drug trigger was identified. We present this review of cases of COVID-associated acute pustular dermatoses to further contribute to the spectrum of cutaneous eruption associated with SARS-CoV-2 infection.

Review of aluminum, paraben, and sulfate product disclaimers on personal care products.

BACKGROUND: Product disclaimers listed on personal care products face limited regulation. These disclaimers may be helpful or may mislead the public. OBJECTIVE: Review the evidence supporting the potential harms of 3 compounds commonly addressed by product disclaimers: parabens, aluminum, and sulfates. METHODS: Reported cases of adverse events to these compounds were identified. Trends in allergic contact dermatitis reactions to chemicals used in place of these compounds were also identified. RESULTS: There is limited evidence that parabens and aluminum pose a threat to human health; there is even less evidence that topical sulfate-containing products pose a danger to consumers. In the setting of paraben avoidance, there has been a steady increase in cases of allergic contact dermatitis to preservatives that are more allergenic, specifically the isothiazolinones. LIMITATIONS: Assessment of the toxicology of these compounds is ongoing and may change with new data. CONCLUSION: There is limited evidence that parabens, aluminum, and sulfates used in personal care products pose a health risk. There is evidence that avoidance of parabens has resulted in an epidemic of allergic contact dermatitis to isothiazolonine preservatives.

The September 11, 2001, terrorist attacks from a dermatology perspective: A remembrance.

The terrorist attacks on September 11, 2001, caused a significant loss of life and resulted in injuries, plus other health issues that continue to plague many survivors and responders to this day. With the 20th anniversary of this tragedy approaching, this contribution looks at the dermatologic injuries suffered on the day of the attacks, including burns and lacerations, along with the chronic skin conditions that have afflicted survivors and responders during the nearly two decades since. These chronic illnesses include sarcoidosis, autoimmune disease, ill-defined skin lesions and irritation, nonmelanoma skin cancer, and melanoma. We also recognize the heroism of first responders who struggled to save the lives of those injured at the World Trade Center and the Pentagon, many of whom have suffered health consequences that continue to have lasting effects on them and on the people they treated.