Efficacy of Systemic Acyclovir as Adjuvant Therapy for Oral Lichen Planus.

BACKGROUND Oral lichen planus (OLP) is a chronic inflammatory disease involving the oral mucosa, associated with the T-cell activity that mediates an autoimmune condition, with various predisposing factors, such as herpes simplex virus (HSV). The first-line treatment is topical corticosteroids. However, additional therapy can be given according to the underlying factors. This report assessed the efficacy of oral acyclovir as adjuvant therapy in the management of OLP. CASE REPORT A 73-year-old man came to our unit reporting he had recurring sores on the tongue for the past 10 years. The tongue was painful and there was taste impairment. Intraoral examination showed erosion and erythematous areas surrounded by white net-like plaques on the tongue and buccal mucosa, as well as depapillation on 2/3 dorsal anterior of the tongue. The diagnosis of reticular and erosive OLP was determined based on clinical features. The patient was prescribed topical corticosteroids, multivitamins, and mouthwash containing chlorine dioxide. Supporting examinations were performed to rule out systemic predisposing factors. The patient was referred for anti-HSV-1 IgG testing, and it was reactive (34.8 U/mL). Thus, oral acyclovir was prescribed. After 2 weeks of antiviral treatment, the tongue pain and altered taste were resolved, and the clinical features showed significant improvement. CONCLUSIONS Management of OLP requires a comprehensive approach. OLP symptoms can be relieved if treatment is not only limited to reducing the inflammation but also seeks to remedy other comorbidities, in this case, administration of an antiviral agent to resolve the HSV-1 involvement.

Clinical variability of recurrent oral HSV-1 infection with a high level of serum IgG antibody: Three case reports.

Recurrent HSV-1 infection has various clinical features. This case report addresses three differences in the oral clinical manifestation of HSV-1 with the same high level of IgG titers reaching 200 U/mL. IgG antibody level indicates the state of recurrency but does not correlate with clinical features.

Preliminary Research: Description of Lip Print Patterns in Children and Their Parents among Deutero-Malay Population in Indonesia.

INTRODUCTION: Human identification is vital not only in legal medicine but also in criminal inquiries and identification. Cheiloscopy is the study of lip prints which are unique, individual, and heritable that is used for personal identification purposes in forensic odontology. OBJECTIVE: The aim of this study is to identify the possibility of the child to inherit the lip print patterns from their parents and also to describe the lip print patterns in children and their parents among the Deutero-Malay population. METHOD: The descriptive research used lip samples of 90 individuals including father, mother, and a child who are biologically related and their age ranges from 12 to 60 years old. The samples chosen are from the Deutero-Malay ethnic in Indonesia at least for the past two generation who obeys all the exclusion criteria of this research. Purposive nonrandom sampling method was used to collect samples by photography technique using a digital camera, and the data obtained were then analysed using Adobe Photoshop CS3 software. Grooves and wrinkles of primary quadrants one, three, six, and seven of lips were studied according to Suzuki and Tsuchihashi's classification in 1971. RESULT: In the present study, it is found that Type I' (30.28%) is the most dominant lip print pattern and Type I (1.39%) is the least dominant among the Deutero-Malay population. Besides, this study has shown that the similarity of lip print pattern between mother and the child (57.89%) is greater compared to the father and the child (42.22%). CONCLUSION: Based on this, we can conclude that lip print can be inherited and dissimilar for every population of race; likewise, the Deutero-Malay population has the Type I' as the most dominant lip print pattern.