1.
Environ Res
; 188: 109858, 2020 09.
Article
in English
| MEDLINE
| ID: mdl-32846644
ABSTRACT
According to numerous recent publications, the COVID-19 patients have lymphopenia, higher infection-related biomarkers and several elevated inflammatory cytokines (i.e. tumor necrosis factor (TNF)-α, interleukin IL-2R and IL-6). The total number of B cells, T cells and NK cells are significantly decreased. RNA viruses, SARS-CoV-2 included, hit the innate immune system in order to cause infection, through TLRs 3, 7 and 8. Imiquimod is an immune-stimulator that activates TLR 7 and can be used to enhance the innate and adaptive immunity. Preclinical and clinical trials are proposed.
Subject(s)
Coronavirus Infections/drug therapy , Imiquimod/therapeutic use , Pneumonia, Viral/drug therapy , Toll-Like Receptor 7/agonists , Adaptive Immunity , Betacoronavirus , COVID-19 , Cytokines , Humans , Immunity, Innate , Pandemics , SARS-CoV-2
2.
Front Immunol
; 11: 1373, 2020.
Article
in English
| MEDLINE
| ID: mdl-32612613