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1.
Ter Arkh ; 79(8): 17-22, 2007.
Article in Russian | MEDLINE | ID: mdl-17926465

ABSTRACT

AIM: To reveal prognostically significant factors affecting efficacy of glivek therapy in untreated (duration of the disease < or = 6 months) and pretreated (duration of the disease > 6 months) patients with chronic myeloid leukemia (CML) in a chronic phase. MATERIAL AND METHODS: A total of 338 patients (64 untreated and 274 pretreated) with a chronic-phase CML on glivek therapy entered the trial. RESULTS: Five-year survival on glivek was high (89, 98 and 88% in untreated and pretreated patients, respectively). Incidence of transformation in the acceleration phase and blast crisis was low both in untreated and pretreated patients (1.6 and 11%, respectively) and correlated with the rate of a complete cytogenetic response (CCR). Untreated patients had no factors affecting treatment efficacy negatively, CCR probability was 96%. Blastemia, thrombocytosis and splenomegaly reduced CCR probability significantly in pretreated patients. Slow reduction of the tumor mass, late achievement of a complete hematological response and a cytogenetic response decreased probability of CCR. CONCLUSION: Glivek is a drug of choice for patients with chronic-phase CML. High probability of CCR both in untreated and pretreated patients lowers the risk of the disease transformation into the phase of acceleration/blast crisis and raises overall survival in both groups.


Subject(s)
Antineoplastic Agents/therapeutic use , Leukemia, Myeloid, Chronic-Phase/drug therapy , Piperazines/therapeutic use , Pyrimidines/therapeutic use , Adolescent , Adult , Aged , Benzamides , Blast Crisis/epidemiology , Blast Crisis/pathology , Disease Progression , Female , Follow-Up Studies , Hematopoiesis/drug effects , Humans , Imatinib Mesylate , Incidence , Leukemia, Myeloid, Chronic-Phase/mortality , Leukemia, Myeloid, Chronic-Phase/pathology , Leukocyte Count , Male , Middle Aged , Prognosis , Protein-Tyrosine Kinases/antagonists & inhibitors , Risk Factors , Russia/epidemiology , Survival Rate/trends , Time Factors
2.
Tsitologiia ; 47(5): 404-16, 2005.
Article in Russian | MEDLINE | ID: mdl-16706144

ABSTRACT

Mesenchymal stem cells (MSCs) have an ability to migrate in the organism to injured tissue to exert influence on inflammation and reparation in these regions. The aim of this study was to determine the optimal time of MSCs transplantation for myocardial reparation in rat experimental heart failure. The experiments were carried out on inbred line Wistar-Kyoto rats. Myocardial experimental infarction (EI) was induced by ligation of the left descending coronary artery. MSCs were isolated from bone marrow, cultivated in vitro and injected into the tail vein on the day of experimental infarction operation. It was shown that the time of MSCs transplantation exerted an essential influence on angiogenesis in a damaged myocardium, on ventricular dilatation and morphological structure of the scar. The best time for MSCs transplantation was determined within two days before EI, and seven days after EI. As a result, the overload of the border zone of infarct region decreased, and no features of infarction relapse were shown in the border zone.


Subject(s)
Heart/physiology , Mesenchymal Stem Cell Transplantation , Myocardial Infarction/surgery , Regeneration , Animals , Disease Models, Animal , Male , Rats , Rats, Inbred WKY , Time Factors
3.
Tsitologiia ; 46(12): 1043-54, 2004.
Article in Russian | MEDLINE | ID: mdl-15747834

ABSTRACT

Mesenchymal stem cells (MSC) are resident pluripotent cells of bone marrow stroma. MSC have the ability to differentiate into osteoblasts, chondroblasts and adipocytes, neurons, glia and also into cardiomyocytes. The problem of MSC use in cell therapy of various diseases and in myocardial infarction therapy is widely discussed at present. The experiments were carried out on the inbred line Wistar--Kyoto rats. Myocardial experimental infarction (EI) was induced by left descending coronary artery ligation. MSC were isolated from bone marrow, cultivated in vitro and injected into the tail vein on the day of experimental infarction operation. It was shown that the structure of injured myocardium in experimental group significantly differed from that in control group. MSC transplantation led to inflammatory process acceleration and to increased angiogenesis in the damaged myocardium; also, live cardiomyocyte layers were detected in the scar. As a result, ventricular dilatation and overload of the border zone of infarct region decreased, no features of infarction relapse were shown in the border zone.


Subject(s)
Mesenchymal Stem Cell Transplantation , Myocardial Infarction/therapy , Myocardium/pathology , Animals , Disease Models, Animal , Male , Myocardial Infarction/physiopathology , Myocytes, Cardiac/physiology , Neovascularization, Physiologic , Rats , Rats, Inbred WKY , Ventricular Remodeling
4.
Vopr Onkol ; 50(6): 726-8, 2004.
Article in Russian | MEDLINE | ID: mdl-15755073

ABSTRACT

Since it exerts a stronger antitumor action than predinisolone, dexamethasone was used for therapy of patients with non-Hodgkin's lymphoma refractory to CHOP. All patients (66), resistant to CHOP, suffered bone marrow involvement. Dexamethasone pulsed therapy was given to 45 patients, with 21 COP-BLAM or ASHAP, MAD, Dexa-BEAM treated in control. Median response duration in high- and low-grade non-Hodgkin's lymphoma groups was 2 and 12 months, respectively.


Subject(s)
Antineoplastic Agents, Hormonal/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Dexamethasone/therapeutic use , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/pathology , Adult , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Carmustine/administration & dosage , Cytarabine/administration & dosage , Dexamethasone/administration & dosage , Etoposide/administration & dosage , Humans , Melphalan/administration & dosage , Middle Aged , Treatment Outcome
5.
Vopr Onkol ; 49(2): 189-92, 2003.
Article in Russian | MEDLINE | ID: mdl-12785203

ABSTRACT

Chronic myeloid leukemia (CML) is a hemopoietic condition caused by chromosomal translocation t(9;22)(q34;q11) or bcr-abl fusion gene. The predominant variants of bcr-abl oncogene rearrangement are b3a2 and b2a2. The present study evaluated the efficacy of interferon-a therapy of CML patients and molecular prognostic factors. Cytogenetic response and complete hematological remission were more frequent in CML b3a2 treatment with interferon-a. Moreover, after therapy, chronic phase lasted in that group (p = 0.026) much longer. Overall survival in the group was significantly longer, too (p = 0.046).


Subject(s)
Antineoplastic Agents/therapeutic use , Interferon-alpha/therapeutic use , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Biomarkers, Tumor/metabolism , Humans , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics , Survival Analysis , Treatment Outcome
6.
Vopr Onkol ; 49(1): 66-70, 2003.
Article in Russian | MEDLINE | ID: mdl-12715373

ABSTRACT

The study included 29 patients with high-grade non-Hodgkin's lymphoma. Nine patients (group 1) received 6-8 cycles of CHOP, another 20-6 cycles of CHOP and Dexa-BEAM followed by autologous hemopoietic cell transplantation with CBV or BEAM conditioning regimen (bone marrow or peripheral stem cells) (group 2). The groups were comparable as far as gender and age are concerned. Overall 5-year survival was in 24.1 and 71.4%, respectively. Double CHOP-Dexa-BEAM plus autologous hemopoietic cell transplantation proved superior to standard CHOP-therapy.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Hematopoietic Stem Cell Transplantation , Lymphoma, Non-Hodgkin/drug therapy , Adult , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Carmustine/administration & dosage , Cyclophosphamide/administration & dosage , Cytarabine/administration & dosage , Dexamethasone/administration & dosage , Doxorubicin/administration & dosage , Drug Administration Schedule , Etoposide/administration & dosage , Female , Humans , Lymphoma, Non-Hodgkin/pathology , Lymphoma, Non-Hodgkin/surgery , Male , Melphalan/administration & dosage , Middle Aged , Prednisone/administration & dosage , Survival Analysis , Transplantation, Autologous , Treatment Outcome , Vincristine/administration & dosage
7.
Vopr Onkol ; 48(6): 668-72, 2002.
Article in Russian | MEDLINE | ID: mdl-12530261

ABSTRACT

The study included 70 patients with high-grade malignant non-Hodgkin's lymphoma (Kiel) who received the following treatment: group 1(24)--6-8 cycles of CHOP; group 2 (relapse or tumor progression after standard chemotherapy--13)--6 cycles of CHOP and Dexa-BEAM, and group 3 (relapse or tumor progression after standard chemotherapy--8)--6 cycles of CHOP plus Dexa-BEAM plus autologous hemopoietic cell transplantation with CBV or BEAM conditioning regimen (bone marrow or peripheral stem cells). The groups were comparable as far as gender and age are concerned. Overall 5-year survival rates were 81, 20 and 48%, respectively. CHOP-Dexa-BEAM plus autologous hemopoietic cell transplantation proved superior to CHOP-Dexa-BEAM alone.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Hematopoietic Stem Cell Transplantation , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/surgery , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Carmustine/administration & dosage , Cyclophosphamide/administration & dosage , Cytarabine/administration & dosage , Dexamethasone/administration & dosage , Doxorubicin/administration & dosage , Etoposide/administration & dosage , Female , Humans , Lymphoma, Non-Hodgkin/pathology , Male , Melphalan/administration & dosage , Middle Aged , Prednisone/administration & dosage , Survival Analysis , Transplantation, Autologous , Treatment Outcome , Vincristine/administration & dosage
8.
Vopr Onkol ; 46(2): 199-201, 2000.
Article in Russian | MEDLINE | ID: mdl-10853421

ABSTRACT

mdr-Transfected K-562 cells revealed a relatively high resistance to cytotoxic monokines and ionizing radiation as compared to parental cells. Taken together with what is known about the resistance of mdr-expressing cells to multiple cytotoxic drugs, our results point to malignant cells having universal mechanisms of chemo-, bio- and radioresistance.


Subject(s)
Genes, MDR , K562 Cells/drug effects , K562 Cells/radiation effects , Monokines/metabolism , Cell Division/drug effects , Cell Division/radiation effects , Gamma Rays , Humans , K562 Cells/metabolism , Macrophages/drug effects , Macrophages/radiation effects , Radiation, Ionizing , Radiotherapy/methods , Transfection
9.
Vopr Onkol ; 45(6): 645-9, 1999.
Article in Russian | MEDLINE | ID: mdl-10703514

ABSTRACT

It was shown that in vitro irradiation (8 Gy) of murine peritoneal macrophages suppressed their spontaneous cytotoxity and induced growth-stimulating activity. Exposure to 4 Gy induced mRNA proximal factors--TGF-beta and TNF-alpha and boosted growth-stimulating activity. These effects should be considered when evaluating efficacy of radiotherapy for tumors.


Subject(s)
Macrophages, Peritoneal/metabolism , Macrophages, Peritoneal/radiation effects , Animals , Mice , Mice, Inbred BALB C , RNA, Messenger/radiation effects , Radiation Dosage , Radiation, Ionizing , Transforming Growth Factor beta/radiation effects , Tumor Necrosis Factor-alpha/radiation effects
10.
Ter Arkh ; 70(7): 11-4, 1998.
Article in Russian | MEDLINE | ID: mdl-9742628

ABSTRACT

AIM: Analysis of cytostatic therapy effects on expression of gene MDR-1 in hemopoietic cells of patients with acute leukemia (AL) in complete clinicohematological remission (CCHR). MATERIALS AND METHODS: The study included 48 AL patients. 27 of them were untreated, 25 were resistant to or had recurrent AL. 4 patients were followed up. Bone marrow mononuclear fraction was investigated. Expression of MDR-1 gene in the cells was evaluated at hybridization. RESULTS: High expression of MDR-1 gene occurred in leukemic blast cells either upon achievement of CCHR or at least 6 months after its onset. When using schemes of chemotherapy containing two potential inductors of gene MDR-1, expression of this gene was registered significantly more frequently than in using schemes based on one inducing drug (p < 0.05). Frequency of occurrence of enhanced expression of gene MDR-1 in leukemic blasts significantly correlated with frequency of CCHR (p < 0.05). Correlation between occurrence of the gene's expression in normal hemopoietic cells in CCHR and occurrence of early AL recurrences was not found. CONCLUSION: The findings may facilitate design of new AL treatment programs.


Subject(s)
Bone Marrow Cells/cytology , Gene Expression Regulation, Leukemic/genetics , Genes, MDR/genetics , Hematopoiesis/genetics , Leukemia, Myeloid, Acute/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Antineoplastic Combined Chemotherapy Protocols/antagonists & inhibitors , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Marrow Cells/drug effects , Drug Resistance, Multiple/genetics , Drug Resistance, Neoplasm/genetics , Gene Expression Regulation, Leukemic/drug effects , Genes, MDR/drug effects , Hematopoiesis/drug effects , Humans , In Situ Hybridization , Leukemia, Myeloid, Acute/drug therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Remission Induction , Time Factors
11.
Ter Arkh ; 70(7): 26-9, 1998.
Article in Russian | MEDLINE | ID: mdl-9742631

ABSTRACT

AIM: To elucidate prognostic value of MDR-1 gene expression in patients with chronic myeloid leukemia (CML). MATERIALS AND METHODS: The MDR-1 gene expression was studied by in situ hybridization in hemopoietic cells of 63 Ph-positive CML patients in different phases of the disease. The survival of the patients and duration of the chronic phase (CP) were evaluated using the Caplan-Meyer method. RESULTS: MDR-1-positive patients had a shorter survival (p < 0.01) and CP (p < 0.05) than negative ones. MDR-1 gene overexpression has no impact either on the survival or duration of AP and BP (p < 0.05). Moreover, the MDR-1 gene overexpression is not dependent either on the previous treatment or other prognostic markers. CONCLUSION: Overexpression of MDR-1 gene is an independent prognostic factor and an additional parameter to Sokal's scores.


Subject(s)
Gene Expression Regulation, Leukemic/genetics , Genes, MDR/genetics , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics , Adolescent , Adult , Aged , DNA Probes , Female , Hematopoietic Stem Cells/cytology , Humans , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/mortality , Male , Middle Aged , Prognosis , Survival Analysis
12.
Vopr Onkol ; 44(3): 300-3, 1998.
Article in Russian | MEDLINE | ID: mdl-9695776

ABSTRACT

The investigation deals with a simplified modification or molecular-genetic detection of translocation t(9;22) using a combination of reverse transcription and polymerase chain reactions (RT-PCR). Unlike the available protocols, analysis is carried out using one enzyme--TET-Z polymerase--(instead of two) which has both revertase and DNA-polymerase activities. The present modification is highly sensitive, less time-consuming and cheaper. The method has proved useful for both diagnosing t(9;22) translocation and diagnosing and monitoring minimal residual disease remaining after marrow transplantation.


Subject(s)
Chromosomes, Human, Pair 22/genetics , Chromosomes, Human, Pair 9/genetics , Neoplasm, Residual/diagnosis , Neoplasm, Residual/genetics , Polymerase Chain Reaction , Translocation, Genetic , Humans , Polymerase Chain Reaction/methods , RNA-Directed DNA Polymerase
13.
Vopr Onkol ; 44(6): 696-700, 1998.
Article in Russian | MEDLINE | ID: mdl-10087967

ABSTRACT

Following monochemotherapy with fludarabin phosphate (fludara), complete (18%), and partial remission (27%) with stabilization (45%) was recorded in patients with B-cell chronic lymphocytic leukemia, most of whom were resistant to alkylating cytostatic drugs and their combinations containing anthracyclines. Long-term remission was registered in patients with low and moderate grade non-Hodgkin's lymphoma, resistant to standard cytostatic treatment, due to the therapeutic synergism of fludara and cytosinarabinoside (FAVAMP).


Subject(s)
Antimetabolites, Antineoplastic/therapeutic use , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Lymphoma, Non-Hodgkin/drug therapy , Vidarabine Phosphate/analogs & derivatives , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Drug Resistance, Neoplasm , Female , Humans , Male , Middle Aged , Treatment Outcome , Vidarabine Phosphate/therapeutic use
14.
Vopr Onkol ; 43(3): 304-8, 1997.
Article in Russian | MEDLINE | ID: mdl-9245087

ABSTRACT

Effects of stromal environment on human leukemic cell apoptosis and proliferation have been investigated. The MS-5 cell line (kindly provided by Dr.Itoh) capable of supporting human hemopoietic cells and the K562 human erythromyeloid leukemic cell line were used. The total increment of cultured leukemic cells was lower than in control due to their co-cultivation with stromal cells, 96% of cells remaining viable. Colony formation by K562 cells appeared to be significantly lower, too (7.2 vs. 22 colonies per 10(3) cells). Inhibition by stromal cells was reproduced when stromal and leukemic cells were separated by a 0.5% agar layer as well as when leukemic cells were cultured on an agar layer which contained a 50% condition medium. Morphological signs of apoptosis in 78.75 +/- 7.64% of leukemic cells, as a result of serum deprivation, were in evidence after 72 hr. while only 14.33 +/- 3.69% of cells co-cultured with MS-5 died. Only 4% of adherent cells showed morphological signs of programmed death. Since protein bcl-2 was not detected in K562 cells it may be suggested that apoptosis of leukemic cells co-cultured with stromal ones does not use the bcl-2 gene pathway. Stromal cell-mediated inhibition of proliferation may be effected through humoral mechanisms.


Subject(s)
Hematopoietic Stem Cells , Leukemia, Myeloid/pathology , Animals , Apoptosis , Cell Division , Humans , Mice , Tumor Cells, Cultured
15.
Biull Eksp Biol Med ; 110(7): 70-2, 1990 Jul.
Article in Russian | MEDLINE | ID: mdl-2224109

ABSTRACT

Cultivation of human bone marrow cells in plasma clot resulted in high efficiency of cloning. It probably results from additional thrombin stimulus on fibroblast-cell proliferation. Another cause of high cloning efficiency is independent of adherence to culture flask surface. Plasma clot system permits clearcut morphological examination. Plasma clot system is in superiority to other culture systems. In this culture system several types of stromal-hemopoietic cells interactions were found, which probably correlate to in vivo interaction of these cells.


Subject(s)
Bone Marrow Cells , Plasma , Stem Cells , Cell Adhesion , Cell Division , Cells, Cultured , Fibroblasts/cytology , Humans
16.
Biull Eksp Biol Med ; 109(2): 140-2, 1990 Feb.
Article in Russian | MEDLINE | ID: mdl-2337645

ABSTRACT

The effect of estrone injections on heterotopic marrow organ formation and femoral hemopoiesis and osteogenesis was studied in C57B1 X CBAF1 mice. Estrone injections resulted in decreased hemopoiesis in femoral marrow, its fibrosis and reduced cellularity of heterotopic organ. Any correlations between osteogenic and hematopoietic tissue were not revealed.


Subject(s)
Bone Marrow/drug effects , Estrone/pharmacology , Hematopoiesis/drug effects , Osteogenesis/drug effects , Animals , Estrone/administration & dosage , Injections , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Primary Myelofibrosis/physiopathology , Time Factors
17.
Tsitologiia ; 32(4): 358-63, 1990.
Article in Russian | MEDLINE | ID: mdl-2238109

ABSTRACT

Transformation of NIH 3T3 cells, induced by v-myc oncogene, activates a proliferative potential of the cells cultivated in the serum-free medium, and reduces the ratio of 3H-Tdr incorporation into the cells grown in the presence of 10% fetal serum in comparison to those grown in the serum-free medium. The v-myc transformed cells (NIH 3T3-v-myc) as well as the untransformed ones are very responsive to insulin. On the other hand, the epidermal growth factor, able to stimulate proliferation of NIH 3T3 cells, exert no effects on the NIH 3T3-v-myc cells. The NIH 3T3-v-myc cells cultivated in the medium, containing 2.5% human plasma enriched with thrombocytes, have the same proliferative characteristics as cells grown in the thrombocyte-free plasma. It is concluded that transformation of NIH 3T3 cells induced by v-myc oncogene may reduce a requirement for thrombocyte-released growth factors and EGF but not for insulin.


Subject(s)
Cell Transformation, Viral/drug effects , Genes, myc , Growth Substances/pharmacology , Animals , Cell Line , Cell Transformation, Viral/physiology , Cells, Cultured/drug effects , Cells, Cultured/metabolism , Mice , Thymidine/metabolism , Tritium
18.
Eksp Onkol ; 12(5): 49-52, 1990.
Article in Russian | MEDLINE | ID: mdl-2226259

ABSTRACT

The inhibiting activity of bone marrow fibroblasts and their ability to sustain survival of granulocytic cell precursors have been studied in patients with chronic myelocytic leukemia, chronic lymphoproliferative disorders, acute leukemia, myelodysplastic syndrome. Fibroblast conditioned medium inhibits proliferation of granulomonocytic precursors stimulated by leucocyte feeder layer or leucocyte conditioned medium. The effect depends both on the presence of monocytes and the specificity of the disease. The inhibitory effect is related with long-ranged factors. Bone marrow fibroblasts are able to sustain survival of hemopoietic precursors via humoral and cell-cell mechanisms. The regulatory role of bone marrow fibroblasts in hemopoietic disorders is discussed.


Subject(s)
Bone Marrow/physiopathology , Granulocytes/physiology , Hematologic Diseases/physiopathology , Hematopoietic Stem Cells/physiology , Monocytes/physiology , Cell Survival , Cells, Cultured , Colony-Forming Units Assay , Fibroblasts/pathology , Fibroblasts/physiology , Granulocytes/pathology , Hematopoietic Stem Cells/pathology , Humans , Leukemia/physiopathology , Lymphoproliferative Disorders/physiopathology , Monocytes/pathology
19.
Vestn Akad Med Nauk SSSR ; (9): 37-41, 1990.
Article in Russian | MEDLINE | ID: mdl-2264386

ABSTRACT

The influence of human fetal bone (FB) on the hemopoietic and stromal cells were studied in the morphometric assay of the bone marrow trephine biopsy samples after a preliminary cultivation using the Marbrook system for 1-5 weeks. The rat FB effect on the hemopoiesis and survival were also studied in experiment with FB transplantation to rats with prior administration of lethal and sublethal doses of cyclophosphamide. In long-term cultivation of the bone marrow trephine biopsy samples, enhanced proliferation of the fibrous tissue and elimination of hemopoietic elements were seen. Combined cultivation of the trephine biopsy samples of the bone marrow and FB inhibited the fibrous tissue proliferation and enhanced the viability of the hemopoietic and lipid cells. Transplantation of the FB in experiment shortened the leukocytopenia period in rats after sublethal (300 mg/kg) and lethal (500 mg/kg) doses of cyclophosphamide and increased their survival.


Subject(s)
Bone Marrow/physiology , Hematopoiesis , Animals , Bone Marrow Cells , Bone Marrow Transplantation , Cells, Cultured , Cyclophosphamide/pharmacology , Embryo, Mammalian , Humans , Rats , Time Factors
20.
Biull Eksp Biol Med ; 108(12): 710-2, 1989 Dec.
Article in Russian | MEDLINE | ID: mdl-2634445

ABSTRACT

The role of thymus in the regulation of stromal elements, responsible for haemopoiesis inducing microsurrounding transfer of animals, subjected to 10-hours immobilization, was studied. The development of bone marrow hyperplasia and stimulation of functional activity of stromal cells, responsible for haemopoiesis inducing microsurrounding transfer, were shown to be thymus dependent processes during stress.


Subject(s)
Hematopoiesis/physiology , Hematopoietic Stem Cells/pathology , Stress, Psychological/physiopathology , Thymus Gland/physiology , Animals , Bone Marrow/physiopathology , Bone Marrow Transplantation , Colony-Forming Units Assay , Hematopoietic Stem Cells/physiology , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Restraint, Physical , Thymectomy
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