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J Environ Sci Health B ; 56(5): 490-502, 2021.
Article in English | MEDLINE | ID: mdl-34019462

ABSTRACT

Obsolete organochlorine pesticides (OSPs) are currently prohibited as persistent organic pollutants that contaminate the environment. If undisposed, they continue to pollute soil and water, to accumulate in the food chain and to harm plants, animals and the human body. The aim of the study was to assess water and soil pollution around the storehouses of undisposed, banned OSPs and their possible genotoxic effect. The storehouses in four villages near Almaty, Kazakhstan were investigated. Chemical analysis confirmed contamination of water and soil around storehouses with OSPs. The genotoxic effect of water and soil samples was evaluated using model objects: S.typhymurium, D.melanogaster, sheep lymphocytes cultures and human lymphocytes cultures. It was found that water and soil samples caused mutagenic effect in all model systems. They increased the frequency of revertants in Salmonella, the frequency of lethal mutations in Drosophila chromosomes, and the frequency of chromosome aberrations in cultures of human and sheep lymphocytes. Although a genotoxic effect was demonstrated for each of these models, various models showed different sensitivity to the effects of pesticides and they varied degree of response. The association between the total content of OCPs in soil and the level of mutations for different model systems was discovered.


Subject(s)
Environmental Pollutants/analysis , Hydrocarbons, Chlorinated/analysis , Mutagens/analysis , Pesticides/analysis , Animals , Environmental Monitoring , Environmental Pollutants/toxicity , Humans , Hydrocarbons, Chlorinated/toxicity , Kazakhstan , Mutagens/toxicity , Pesticides/toxicity , Risk Assessment
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