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1.
HNO ; 64(12): 917-921, 2016 Dec.
Article in German | MEDLINE | ID: mdl-27858099

ABSTRACT

Paragangliomas are highly vascularized usually benign neoplasms originating from the sympathoadrenal and parasympathetic paraganglia of the autonomic nervous system. When resectable, the management of these tumors consists of surgical ablation preceded by transarterial embolization. The aim of this article is to describe a novel treatment strategy combining intralesional percutaneous embolization with dissection using ultrasound scissors. The case of a 74-year-old women presenting with a Shamblin type III carotid body paraganglioma is presented. The combined approach of percutaneous embolization and ultrasound scissors permitted complete resection of the tumor with preservation of both the internal and external carotid artery, without postoperative cranial nerve deficits and with minimal blood loss. Preoperative intralesional embolization with a liquid embolic agent less than 24 h prior to surgical intervention in combination with ultrasound scissors appears to be an excellent strategy for surgical management of carotid body paragangliomas.


Subject(s)
Carotid Body Tumor/diagnosis , Carotid Body Tumor/therapy , Combined Modality Therapy/methods , Embolization, Therapeutic/methods , High-Intensity Focused Ultrasound Ablation/methods , Aged , Female , Humans , Treatment Outcome
3.
Forensic Sci Int ; 225(1-3): 32-41, 2013 Feb 10.
Article in English | MEDLINE | ID: mdl-22721937

ABSTRACT

Cases of fatal outcome after surgical intervention are autopsied to determine the cause of death and to investigate whether medical error caused or contributed to the death. For medico-legal purposes, it is imperative that autopsy findings are documented clearly. Modern imaging techniques such as multi-detector computed tomography (MDCT) and postmortem CT angiography, which is used for vascular system imaging, are useful tools for determining cause of death. The aim of this study was to determine the utility of postmortem CT angiography for the medico-legal death investigation. This study investigated 10 medico-legal cases with a fatal outcome after surgical intervention using multi-phase postmortem whole body CT angiography. A native CT scan was performed as well as three angiographic phases (arterial, venous, and dynamic) using a Virtangio(®) perfusion device and the oily contrast agent, Angiofil(®). The results of conventional autopsy were compared to those from the radiological investigations. We also investigated whether the radiological findings affected the final interpretation of cause-of-death. Causes of death were hemorrhagic shock, intracerebral hemorrhage, septic shock, and a combination of hemorrhage and blood aspiration. The diagnoses were made by conventional autopsy as well as by postmortem CT angiography. Hemorrhage played an important role in eight of ten cases. The radiological exam revealed the exact source of bleeding in seven of the eight cases, whereas conventional autopsy localized the source of bleeding only generally in five of the seven cases. In one case, neither conventional autopsy nor CT angiography identified the source of hemorrhage. We conclude that postmortem CT angiography is extremely useful for investigating deaths following surgical interventions. This technique helps document autopsy findings and allows a second examination if it is needed; specifically, it detects and visualizes the sources of hemorrhages in detail, which is often of particular interest in such cases.


Subject(s)
Angiography/methods , Autopsy , Intraoperative Complications/pathology , Multidetector Computed Tomography , Postoperative Complications/pathology , Adolescent , Aged , Cerebral Hemorrhage/pathology , Contrast Media , Exsanguination/pathology , Female , Forensic Pathology , Humans , Iatrogenic Disease , Male , Malpractice , Middle Aged , Respiratory Aspiration/pathology , Retrospective Studies , Shock, Hemorrhagic/pathology , Shock, Septic/pathology
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