Subject(s)
Anemia, Sickle Cell/complications , Angioid Streaks/diagnostic imaging , Angioid Streaks/etiology , Anemia, Sickle Cell/diagnosis , Anemia, Sickle Cell/genetics , Angioid Streaks/diagnosis , Fluorescein Angiography , Fundus Oculi , Hemoglobin, Sickle/genetics , Homozygote , Humans , Male , Middle AgedSubject(s)
Boutonneuse Fever/complications , Eye Infections, Bacterial/complications , Macula Lutea/pathology , Retinal Degeneration/etiology , Adult , Atrophy , Boutonneuse Fever/diagnosis , Eye Infections, Bacterial/diagnosis , Female , Fluorescein Angiography , Fundus Oculi , Humans , Retinal Degeneration/diagnosis , Tomography, Optical CoherenceSubject(s)
Orthopedic Procedures/adverse effects , Retinal Artery Occlusion/etiology , Vision Disorders/etiology , Fracture Fixation, Internal/adverse effects , Humans , Male , Middle Aged , Postoperative Complications/diagnosis , Retinal Artery Occlusion/diagnosis , Tibial Fractures/surgery , Tomography, Optical Coherence , Vision Disorders/diagnosisSubject(s)
Ascomycota/physiology , Endophthalmitis/diagnosis , Endophthalmitis/microbiology , Eye Infections, Fungal/diagnosis , Eye Infections, Fungal/microbiology , Administration, Oral , Ascomycota/drug effects , Ascomycota/isolation & purification , Ascomycota/pathogenicity , Ceftazidime/administration & dosage , Diabetes Mellitus, Type 2/blood , Diabetes Mellitus, Type 2/complications , Endophthalmitis/drug therapy , Eye Infections, Fungal/drug therapy , Humans , Intravitreal Injections , Male , Middle Aged , Mitosporic Fungi/drug effects , Mitosporic Fungi/isolation & purification , Mitosporic Fungi/pathogenicity , Mitosporic Fungi/physiology , Vancomycin/administration & dosage , Voriconazole/administration & dosageSubject(s)
Cataract Extraction/adverse effects , Corneal Opacity/surgery , Corneal Perforation/diagnosis , Corneal Perforation/etiology , Lens Implantation, Intraocular/adverse effects , Aged , Anterior Chamber/pathology , Anterior Chamber/surgery , Cataract/complications , Cataract/therapy , Corneal Opacity/complications , Humans , Lenses, Intraocular , Male , Tissue Adhesions/complications , Tissue Adhesions/pathology , Tissue Adhesions/surgerySubject(s)
Cicatrix/diagnosis , Cicatrix/etiology , Toxoplasmosis, Congenital/complications , Toxoplasmosis, Congenital/diagnosis , Toxoplasmosis, Ocular/complications , Toxoplasmosis, Ocular/diagnosis , Chorioretinitis/diagnosis , Chorioretinitis/etiology , Chorioretinitis/pathology , Cicatrix/pathology , Humans , Male , Morocco , Toxoplasmosis, Congenital/pathology , Toxoplasmosis, Ocular/pathology , Young AdultSubject(s)
Eyelid Neoplasms/diagnosis , Hemangioma/diagnosis , Abdominal Neoplasms/diagnosis , Abdominal Neoplasms/drug therapy , Abdominal Neoplasms/pathology , Eyelid Neoplasms/drug therapy , Eyelid Neoplasms/pathology , Eyelids/pathology , Female , Hemangioma/drug therapy , Hemangioma/pathology , Humans , Infant , Propranolol/therapeutic use , Tumor Burden/drug effectsSubject(s)
Endophthalmitis/etiology , Klebsiella Infections/complications , Klebsiella pneumoniae , Liver Abscess/complications , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/microbiology , Endophthalmitis/microbiology , Endophthalmitis/pathology , Eye Infections, Bacterial/microbiology , Eye Infections, Bacterial/pathology , Humans , Klebsiella Infections/pathology , Klebsiella pneumoniae/isolation & purification , Liver Abscess/pathology , Male , Middle Aged , Uveitis/microbiology , Uveitis/pathologyABSTRACT
INTRODUCTION: Best's disease is a progressive macular dystrophy, beginning either in childhood or adolescence. CASE STUDY: We report a rare case of choroidal neovascularization complicating vitelliform dystrophy in a child of 8 years with bilateral progressive loss of visual acuity. The ophthalmoscopic examination showed vitelliform lesions in both foveas. Fluorescein angiography confirmed a subretinal neovascular membrane in the left eye. Additional testing also confirmed the diagnosis of Best's disease associated with choroidal neovascularization. DISCUSSION: Best's vitelliform macular dystrophy is often asymptomatic because visual acuity tends to remain stable for a long time. A sudden loss of vision suggests the occurrence of complications, such as choroidal neovascularization.
Subject(s)
Choroidal Neovascularization/etiology , Vitelliform Macular Dystrophy/complications , Child , Electrooculography , Fluorescein Angiography , Humans , Male , Ophthalmoscopy , Slit Lamp , Tomography, Optical Coherence , Visual Acuity , Vitelliform Macular Dystrophy/diagnosisSubject(s)
Antineoplastic Agents/therapeutic use , Carcinoma, Squamous Cell/drug therapy , Conjunctival Neoplasms/drug therapy , Cryotherapy , Mitomycin/therapeutic use , Neoplasms, Radiation-Induced/drug therapy , Xeroderma Pigmentosum/complications , Antineoplastic Agents/administration & dosage , Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Child , Combined Modality Therapy , Conjunctival Neoplasms/etiology , Conjunctival Neoplasms/pathology , Conjunctival Neoplasms/surgery , Consanguinity , Contraindications , Eye Enucleation , Female , Genetic Predisposition to Disease , Humans , Mitomycin/administration & dosage , Neoplasm Invasiveness , Neoplasms, Radiation-Induced/etiology , Neoplasms, Radiation-Induced/pathology , Neoplasms, Radiation-Induced/surgery , Neoplasms, Second Primary , Ophthalmic Solutions , Ophthalmologic Surgical Procedures , Remission Induction , Skin Neoplasms/etiology , Sunlight/adverse effects , Xeroderma Pigmentosum/classification , Xeroderma Pigmentosum/geneticsABSTRACT
PURPOSE: The purpose of this study is to evaluate the diagnostic ability of segmentation of the various internal macular layers by spectral domain optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec (CZM), Dublin, CA, USA) and to compare it to that of the peripapillary retinal nerve fiber layer (cpRNFL) in primary open angle glaucoma (POAG). MATERIALS AND METHODS: This study included 252 eyes diagnosed with primary open angle glaucoma (POAG) (164 early POAG, 44 moderate POAG and 44 advanced POAG) and 223 eyes of control subjects. All patients underwent visual field testing (Humphrey Field Analyser, SITA-Standard 24-2, CZM), and SD-OCT imaging (Cirrus HD-OCT) of the macular and optic nerve head regions (ganglion cell analysis (GCA), macular cube 200×200; optic disc cube 200×200). OCT macular scans were segmented into macular nerve fiber layer (mNFL), ganglion cell layer with inner plexiform layer (GCIPL), outer retinal layers, and ganglion cell complex (GCC) (mNFL+GCIPL). Glaucoma discriminating ability was assessed using the area under the receiver operator characteristic curve (AUC) for all macular parameters and mean circumpapillary retinal nerve fibre layer (cpRNFL). RESULTS: For the entire POAG population of this study, the minimum GCIPL index provided greater diagnostic ability than the other parameters studied, with a statistically significant difference in their AUC (minimum GCIPL [0.887], mean GCIPL [0.865], GCC [0.863], cpRNFL [0.823], mean mNFL [0.786] and minimum mNFL [0.742]). The results were similar in the early POAG group but without any statistically significant difference with the cpRNFL parameter. In the moderate POAG group, the diagnostic ability was similar for all indices, whereas in the advanced POAG group, minimum GCIPL and GCC gave the largest AUC indices. DISCUSSION AND CONCLUSION: The minimum macular GCIPL is a new index obtained with the GCA algorithm of the Cirrus HD-OCT. It appears to have an excellent ability to detect glaucoma at every stage and demonstrates performance comparable to that of the cpRNFL parameter, in combination with which it may provide important complementary information for clinical practice.