The effect of ambient temperature on hand, foot and mouth disease in Qingdao, China, 2014-2018.

Hand, foot, and mouth disease (HFMD) is a kind of infection gastrointestinal disease. The present study aims to explore the association between ambient temperature and HFMD in Qingdao. A distributed lag nonlinear model with Poisson distribution was adopted to explore the effects of daily mean temperature on HFMD incidence. Our results found that the high temperature had acute and short-term effects and then declined rapidly along the lag days, with the maximum risk occurring 0 day of exposure. Compared with low temperature, higher effects were observed for high-temperature exposure. Overall, we found that the association between temperature and HFMD incidence was non-linear, exhibiting an approximate "J" shape, with peak value occurring at 30.5℃ (RR = 2.208, 95% CI: 1.995-2.444). Our findings suggest that ambient temperature is significantly associated with the incidence of HFMD in Qingdao. Monitoring ambient temperature changes is an appropriate recommendation to prevent HFMD.

Estimating the influence of high temperature on hand, foot, and mouth disease incidence in China.

The burden of disease caused by ambient high temperature has become a public health concern, but the associations between high temperature and hand, foot, and mouth disease (HFMD) remain indistinct. We used distributed lag non-linear model (DLNM) to estimate the burden of disease attribute to high temperature, adjusting for long-term trend and weather confounders. Total 18,167,455 cases were reported in 31 Chinese provinces, the incidence of HFMD showed a gradually increasing trend from 2008 to 2017 in China. Minimum morbidity temperature (MMT) was mainly concentrated at 17 to 23 °C in ≤ 5 years old group, 18 to 25 °C in 6 ~ 10 years old group and 19 to 27 °C in > 10 years old group. The greatest relative risk (RR) in age group ≤ 5 years old was 2.06 (95% CI: 1.85 ~ 2.30) in Heilongjiang, and the lowest RR was 1.02 (95% CI: 1.00 ~ 1.05) in Guangdong; the greatest RR in age group 6 ~ 10 years old was 2.24 (95% CI: 1.72 ~ 2.91) in Guizhou, and the lowest RR was 1.01 (95% CI: 0.97 ~ 1.12) in Tianjin; the greatest RR in the age group > 10 years old was 2.53 (95% CI: 1.66 ~ 3.87) in Heilongjiang, and the lowest RR was 1.02 (95% CI: 0.71 ~ 1.46) in Henan. We found the positive association between high temperature and HFMD in China.

Involuntary Retirement and Depression Among Adults: A Systematic Review and Meta-Analysis of Longitudinal Studies.

Results from longitudinal studies on involuntary retirement and depression remain controversial. PubMed, Web of Science, Embase, ScienceDirect, Wanfang, and VIP updated on 4 January 2022 were searched for eligible publications. Pooled relative risks (RRs) with 95% confidence interval (CI) were calculated using a random-effects model. Eight published articles with 14,604 participants for the effect of involuntary retirement on depression incidence and 26,822 participants for the relationship between depression and involuntary retirement were included. Compared with working, the pooled RR for depression was 1.31 (95% CI, 1.13-1.51; I 2 = 37.7%) for the involuntary retirement overall. For involuntary retirement, the pooled RR was 1.70 (95% CI, 1.28-2.25; I 2 = 84.2%). The associations between involuntary retirement and depression did not substantially change in sensitivity and subgroup analyses. No evidence of publication bias was found. This meta-analysis indicates that there might be mutual causal relationship between involuntary retirement and depression. More large longitudinal studies with different gender and income levels are needed.

[Preparation and Application of Magnetic Water Treatment Materials Based on Iron Sludge].

In recent years, solid waste iron sludge (red mud, iron-containing water treatment residues, and iron-rich sludge) has been widely used to remove pollutants in the water environment; however, the difficulty of separating powdered iron sludge from the water environment media makes it impossible to apply it as a water treatment material on a large scale, and preparing iron sludge into magnetic materials that are easy to be separated is one of the effective strategies to solve this bottleneck. According to the existing research on iron sludge-based magnetic materials at home and abroad, the preparation methods of magnetic materials using iron sludge as raw materials are summarized, including a series of methods, including the thermal decomposition method, hydrothermal and solvothermal method, co-precipitation method, reduction roasting method, and carbonization method. Additionally, it is pointed out that the currently commonly used preparation methods are thermal decomposition, hydrothermal and solvothermal, and co-precipitation. In addition, the performance and application of these magnetic materials as adsorbents or catalysts in water treatment are also summarized. In general, iron sludge-based magnetic materials can better absorb heavy metals and organic pollutants in water. The main adsorption mechanisms are complexation, electrostatic interaction, reduction, cation exchange, and precipitation. As a catalyst, it can efficiently oxidize and degrade organic pollutants by generating strong oxidizing substances:SO4-· and ·OH. Although there have been many studies on the preparation and application of iron sludge-based magnetic materials, because the raw material iron sludge contains many impurities, the magnetic materials prepared from iron sludge also have certain impurities. Therefore, it is still necessary to strengthen the research on the safety of iron sludge-based magnetic materials in the future to further ensure that they can be used as environmentally friendly materials for water environment restoration.

Effects of ambient temperature on cardiovascular disease: a time-series analysis of 229288 deaths during 2009-2017 in Qingdao, China.

The association between ambient temperature and cardiovascular mortality varied by regions, populations, and climates. We estimated the relative risk (RR) of cardiovascular mortality using 229,288 death cases of cardiovascular disease in Qingdao China from 1 January 2009, to 31 December 2017. A distributed lag non-linear model was used. The temperature showed a negative association with the cardiovascular mortality. The RR of cardiovascular death at -4.8 °C was 2.05 (95% CI: 1.55, 2.69). The high temperature had acute and short-term effects with the maximum risk occurring 0 day of exposure. The low temperature had the greatest effect on the 4th lag day. The cold temperature effect was stronger for males than females. The estimates of temperature-related cardiovascular mortality risk were higher in people age ≥75 years. Our study showed that the cold and hot ambient temperature had a relationship with the risk of cardiovascular mortality.

Pesticide poisoning risk attributable to ambient temperature: a time series analysis in Qingdao China during 2007-2018.

Pesticide poisoning prevention has become a public health issue of great concern. We estimated the association between temperature and attributable risk of pesticide poisoning using 3,545 pesticide poisoning cases in Qingdao China from June 2007 to July 2018. A distributed lag non-linear model was applied to estimate the temperature-pesticide poisoning associated with the assessment of attributable number and fraction. The hot temperature is responsible for the pesticide poisoning incidence, with backward and forward attributable fractions, respectively, 7.79% and 7.61%. Most of the pesticide poisoning burden (backward attributable fraction 5.30% and forward attributable fraction 5.06%) was caused by mild hot (22°C-26°C), whereas the burden due to extreme hot (27°C-31°C) was small (backward attributable fraction 2.94% and forward attributable fraction 2.69%).

First-Principle Study on the Stability of Lightly Doped (Nb1-x Ti x )C Complex Carbides and Their Verification in 1045 Steel.

The mixing Gibbs free energy and formation enthalpy difference of different Ti-doped (Nb1-x Ti x )C complex carbides were calculated using the Cambridge Serials Total Energy Package (CASTEP) module of Materials Studio 2019 software. The calculation results predict that (Nb1-x Ti x )C complex carbides have higher stability than pure NbC and TiC. Therefore, three lightly Ti-doped (Nb1-x Ti x )C complex carbides with theoretical densities close to that of the 1045 steel were designed for calculations. The calculation results show that the formation energy of (Nb1-x Ti x )C complex carbides decreases with an increase in the Ti content. These designed (Nb1-x Ti x )C complex carbides have mechanical stability, and their bulk modulus, shear modulus, Young's modulus, and hardness are all lower than those of pure NbC. The electronic performance results show that these three structures show good conductivity, and the 3d orbitals of Ti atoms and the 4d orbitals of Nb atoms are strongly hybridized with the 2p orbitals of C atoms. The Nb-C and Ti-C bonds exhibit strong covalent bonds. To verify the stability of the (Nb1-x Ti x )C complex carbides, the prepared (Nb0.8Ti0.2)C complex carbide was added to the 1045 steel as a refiner. After observing under a transmission electron microscope (TEM), we found that the (Nb0.8Ti0.2)C complex carbide could exist stably as a face-centered cubic structure, which provided a method for the design and synthesis of complex carbides used for refiners.

Longitudinal Association of Sleep Duration with Depressive Symptoms among Middle-aged and Older Chinese.

This study aimed to evaluate the associations of nighttime sleep duration and midday napping with risk of depressive symptoms incidence and persistence among middle-aged and older Chinese. Data from China Health and Retirement Longitudinal Study, CHARLS (2011-2013), were analyzed. Depressive symptoms were identified by the 10-item version of the Centre for Epidemiological Studies Depression scale (CESD-10). Multivariate binary logistic regression models were fitted. There were 7156 individuals with CESD-10 scores < 10 and 3896 individuals with CESD-10 scores ≥ 10 at baseline included in this study. After controlling for potential covariates, nighttime sleep duration <6 hours was associated with high risk of incident depressive symptoms (OR = 1.450, 95%CI: 1.193, 1.764 for middle aged population, and OR = 2.084, 95%CI:1.479, 2.936 for elderly) and persistent depressive symptoms (OR = 1.404, 95%CI: 1.161, 1.699 for middle aged population, and OR = 1.365, 95%CI: 0.979, 1.904 for elderly). For depressed individuals, longer midday napping (≥60 minutes) was associated with lower persistent depressive symptoms (OR = 0.842, 95%CI: 0.717, 0.989). Our study concluded that short nighttime sleep duration was an independent risk factor of depressive symptoms incidence and persistence. Depressed individuals with long midday napping were more likely to achieve reversion than those who have no siesta habit.

A Prospective Study on the Association between Uric Acid and Cognitive Function among Middle-Aged and Older Chinese.

BACKGROUND: Uric acid (UA) is a powerful antioxidant that may have neuroprotective properties, yet it is also a risk factor of vascular disease that predisposes individuals to cognitive impairment. Results from longitudinal studies on UA and cognitive decline remain controversial. OBJECTIVE: We examined the associations of baseline plasma UA level with follow-up cognitive function as well as cognitive decline over time among a large sample of middle-aged and older Chinese. METHODS: Data from China Health and Retirement Longitudinal Study (CHARLS) were used. Cognitive function, including episodic memory, mental intactness, and global cognition, were tested twice with 2-year interval. Plasma UA was measured at baseline. Basic demographics, life habits, and health status were considered as potential confounders. Multiple linear regression models and mixed-effects regression models were fitted. RESULTS: A total of 12,798 individuals aged above 45 years were eligible with the follow-up time ranging from 1.33 to 2.42 years. Both global cognitive function and mental intactness declined, while episodic memory remained stable over time. In multiple linear regression models, compared with the lowest baseline UA level, 3rd baseline UA quartile was associated with better follow-up global cognitive function (b = 0.425, p = 0.041) and episodic memory (b = 0.413, p = 0.004), and highest baseline UA quartile was associated with better follow-up mental intactness (b = 0.253, p = 0.041) in males; highest baseline UA level was associated with better follow-up cognition for each measure (b = 0.281∼0.768, p≤0.046) in females. Mixed-effects regression models suggested no significant baseline UA-by-time interactions on any cognitive measure. CONCLUSION: Higher baseline UA level was associated with better cognition in later life but not with rates of cognitive decline among middle-aged and older Chinese.

SLEEP DURATION AND DEPRESSION AMONG ADULTS: A META-ANALYSIS OF PROSPECTIVE STUDIES.

BACKGROUND: Results from longitudinal studies on sleep duration and incidence of depression remain controversial. METHODS: PubMed and Web of Science updated on October 22, 2014 were searched for eligible publications. Pooled relative risks (RRs) with 95% confidence interval (CI) were calculated using a random-effects model. RESULTS: Seven prospective studies were included, involving 25,271 participants for short sleep duration and 23,663 participants for long sleep duration. Compared with the normal sleep duration, the pooled RR for depression was 1.31 (95% CI, 1.04-1.64; I(2) = 0%) for the short sleep duration overall. For long sleep duration, the pooled RR was 1.42 (95% CI, 1.04-1.92; I(2) = 0%). The associations between short or long sleep duration and risk of depression did not substantially change in sensitivity and subgroup analyses. No evidence of publication bias was found. CONCLUSION: This meta-analysis indicates that short and long sleep duration was significantly associated with increased risk of depression in adults.

Association of cholesterol with risk of pancreatic cancer: a meta-analysis.

AIM: To evaluate the effect of dietary cholesterol and serum total cholesterol (TC) on the risk of pancreatic cancer. METHODS: A literature search was performed up to June 2014 in PubMed, EMBASE, China National Knowledge Infrastructure and China Biology Medical literature database for relevant articles published in English or Chinese. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model. RESULTS: We included 14 published articles with 439355 participants for dietary cholesterol, and 6 published articles with 1805697 participants for serum TC. For the highest vs lowest category of dietary cholesterol, the pooled RR (95%CI) of pancreatic cancer was 1.308 (1.097-1.559). After excluding two studies (RR > 3.0), the pooled RR (95%CI) was 1.204 (1.050-1.380). In subgroup analysis stratified by study design, the pooled RRs (95%CIs) were 1.523 (1.226-1.893) for case-control studies and 1.023 (0.871-1.200) for cohort studies. The association of dietary cholesterol with the risk of pancreatic cancer was significant for studies conducted in North America [1.275 (1.058-1.537)] and others [2.495 (1.565-3.977)], but not in Europe [1.149 (0.863-1.531)]. No significant association [1.003 (0.859-1.171)] was found between the risk of pancreatic cancer and serum TC. CONCLUSION: Dietary cholesterol may be associated with an increased risk of pancreatic cancer in worldwide populations, except for Europeans. The results need to be confirmed further.

Dietary carbohydrate and prostate cancer risk: a meta-analysis.

Carbohydrate intake has been inconsistently associated with risk of prostate cancer. We review and quantitatively summarize the evidence from observational studies in a meta-analysis. We searched the PubMed database for observational studies related to the association of carbohydrate intake and prostate cancer risk up to December 25, 2013. Summary relative risks (RRs) were estimated by the use of a random effects model. We included 13 case-control studies with 4,367 cases and 6,205 controls, and 5 cohort studies with 3,679 cases and 74,115 participants in this meta-analysis. The summary RR of prostate cancer for the highest vs. the lowest carbohydrate intake was 1.06 [95% confidence interval (CI): 0.93-1.20, I(2) = 46.8%] for all included studies. In the subgroup analyses stratified by study design, the summary RRs for the highest vs. the lowest carbohydrate intake were 1.04 (95% CI: 0.87-1.23) for case-control studies and 1.06 (95% CI: 0.88-1.28) for cohort studies. For the 5 studies that reported results for advanced prostate cancer, the summary RR was 0.92 (95% CI: 0.71-1.20). This meta-analysis of observational studies indicates that there is no association between carbohydrate intake and prostate cancer risk. Further studies are needed to confirm our findings.

Sedentary behaviour and the risk of depression: a meta-analysis.

BACKGROUND: Sedentary behaviour is associated with risk of depression. We review and quantitatively summarise the evidence from observational studies in a meta-analysis. METHODS: We searched the PubMed, Web of Knowledge, Chinese National Knowledge Infrastructure and Wanfang databases for observational studies related to the association of sedentary behaviour and depression risk up to 15 January 2014. Summary relative risks (RRs) were estimated by the use of a random effects model. RESULTS: Thirteen cross-sectional studies with 110,152 participants and 11 longitudinal studies with 83,014 participants were included in this meta-analysis. The summary RR of depression for the highest versus non-occasional/occasional sedentary behaviour was 1.25 (95% CI 1.16 to 1.35, I(2)=50.7%) for all included studies. The pooled RRs of depression for sedentary behaviour were 1.31 (95% CI 1.16 to 1.48) in cross-sectional studies and 1.14 (95% CI 1.06 to 1.21) in longitudinal studies. In subgroup analysis by different types of sedentary behaviour, the pooled RRs of depression were 1.13 (95% CI 1.06 to 1.21) for long-time TV viewing and 1.22 (95% CI 1.10 to 1.34) for prolonged computer or internet use. CONCLUSIONS: This meta-analysis of observational studies indicates that sedentary behaviour is associated with increased risk of depression.

Effect of recombinant human bone morphogenetic protein 2/poly-lactide-co-glycolic acid (rhBMP-2/PLGA) with core decompression on repair of rabbit femoral head necrosis.

OBJECTIVE: To observe the effect of recombinant human bone morphogenetic protein 2/poly-lactide-co-glycolic acid (rhBMP-2/PLGA) with core decompression on repair of rabbit femoral head necrosis. METHOD: Bilateral femoral head necrosis models of rabbit were established by steroid injection. A total of 48 rabbits (96 femoral head necrosis) were randomly divided into 4 groups: Group A, control group with12 rabbits, 24 femoral head necrosis; Group B, treated with rhBMP-2/PLGA implantation after core depression, with 12 rabbits, 24 femoral head necrosis; Group C, treated with rhBMP-2 implantation after core depression, with 12 rabbits, 24 femoral head necrosis; Group D treated with core depression group without implantation, with 12 rabbits, 24 femoral head necrosis. All animals were sacrificed after 12 weeks. The ability of repairing bone defect was evaluated by X-ray radiograph. Bone mineral density analysis of the defect regions were used to evaluate the level of ossification. The morphologic change and bone formation was assessed by HE staining. The angiogenesis was evaluated by VEGF immunohistochemistry. RESULTS: The osteogenetic ability and quality of femoral head necrosis in group B were better than those of other groups after 12 weeks by X-ray radiograph and morphologic investigation. And the angiogenesis in group B was better than other groups. Group C had similar osteogenetic quality of femoral head necrosis and angiogenesis with group D. CONCLUSION: The treatment of rhBMP-2/PLGA implantation after core depression can promote the repair of rabbit femoral head necrosis. It is a promising and efficient synthetic bone material to treat the femoral head necrosis.

Sleep duration and obesity among adults: a meta-analysis of prospective studies.

BACKGROUND: Results from longitudinal studies on sleep duration and incidence of obesity remain controversial. METHODS: PubMed and Web of Science updated on 20 February 2014 were searched for eligible publications. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using a random-effects model. RESULTS: Eleven published articles were included, involving 197,906 participants for short sleep duration and 164,016 participants for long sleep duration. Compared with the normal sleep duration, the pooled OR for obesity was 1.45 (95% CI, 1.25-1.67) for the short sleep duration overall. After removing the three studies that had strong effects on heterogeneity, the pooled OR was 1.25 (95% CI, 1.14-1.38). The positive association was consistent among all subgroups analysis except in the European group (OR, 1.45; 95% CI, 0.79-2.64). No significant association was found between long sleep duration and risk of obesity overall (OR, 1.06; 95% CI, 0.98-1.15) and in subgroup analysis. CONCLUSION: This meta-analysis indicated that short sleep duration was significantly associated with incidence of obesity, whereas long sleep duration had no effect on future obesity among adults.

[Arthroscopic surgery for severe elbow osteoarthritis and ankylosis].

OBJECTIVE: to investigate the clinical efficacy of arthroscopic debridement, shaping and soft tissue releasing in the treatment of severe elbow osteoarthritis and ankylosis. METHODS: arthroscopies were performed in 34 patients with severe elbow osteoarthritis. Among them, 13 were accompanied by ankylosis. In arthroscopic surgery, articular cavity was cleared. And loose bodies, osteophytes of coronoid process and olecranon of ulna were excised, the coracoid fossa and olecranon fossa shaped and joint capsules and collateral ligaments severely contracted properly released. Rehabilitation training was guided postoperatively. Arthralgia and range of motion of elbow were scored by Mayo's scoring criteria in contrast with that preoperatively. RESULTS: the pain and range of motion (ROM) of elbow improved obviously in 34 patients. Angle of extension postoperatively increased by 30° ± 16° and angle of flexion increased by 34° ± 19°. Postoperative ROM of elbow show significant difference with the preoperative status (P < 0.01). According to the Mayo's scoring criteria, the excellent and good rate was 85.3%. CONCLUSION: arthroscopic treatment of severe osteoarthritis and ankylosis of elbow is reliable. Trauma of arthroscopy is minimal and complications are rare.