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1.
J Asian Nat Prod Res ; 17(10): 996-1001, 2015.
Article in English | MEDLINE | ID: mdl-26120736

ABSTRACT

Two new triterpenoids, termichebuloside A (1), an unusual dimeric triterpenoid saponin, and termichebulolide (2), an oleanolic acid-type lactone, along with 11 known triterpenoids, were isolated from MeOH extract of the barks of Terminalia chebula. The structures of 1 and 2 were elucidated to be arjunglucoside I-(3-O-19',23-O-19')-18,19-seco-19-hydroxyarjunglucoside I (1) and 2α,3ß,23-trihydroxyolean-11,13(18)-dien-28,19ß-olide (2), respectively, on the basis of spectroscopic evidences and biogenetic consideration.


Subject(s)
Saponins/isolation & purification , Terminalia/chemistry , Triterpenes/isolation & purification , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Plant Bark/chemistry , Saponins/chemistry , Stereoisomerism , Triterpenes/chemistry
2.
J Psychiatr Res ; 43(2): 124-8, 2008 Dec.
Article in English | MEDLINE | ID: mdl-18423490

ABSTRACT

BACKGROUND: While most of the second generation antipsychotic agents are associated with abnormal glucose metabolism, previous studies have shown that risperidone has relatively little effect upon blood glucose levels. This study aimed to explore the effect of risperidone on the glucose-regulating mechanism of patients with schizophrenia by using the oral glucose tolerance test (OGTT), measuring insulin and C-peptide levels. METHODS: Thirty inpatients with schizophrenia taking risperidone were studied. All the patients were given a simplified OGTT at baseline and six weeks after treatment. Plasma glucose, insulin, and C-peptide concentrations were measured at fasting, then 1 and 2h after OGTT respectively. Other data, including demographic characteristics and plasma drug concentrations, were also recorded. RESULTS: (1) There was no significant increase in the proportion of patients demonstrating abnormal plasma glucose levels compared with baseline (p=1.000, McNemar test); (2) risperidone was associated with elevated insulin concentrations (p=0.013), C-peptide levels (p=0.020), insulin/glucose ratio (p=0.020) and BMI (p<0.01); (3) no sex differences in glucose-related measures were observed. CONCLUSION: Risperidone treatment may be associated with alterations in glucose-regulating mechanisms in patients with schizophrenia.


Subject(s)
Antipsychotic Agents/therapeutic use , Blood Glucose/metabolism , Risperidone/therapeutic use , Schizophrenia/blood , Adult , Antipsychotic Agents/blood , Blood Glucose/drug effects , Body Mass Index , C-Peptide/blood , C-Peptide/drug effects , China , Cohort Studies , Female , Glucose Tolerance Test/methods , Glucose Tolerance Test/statistics & numerical data , Humans , Insulin/blood , Male , Prospective Studies , Risperidone/blood , Schizophrenia/drug therapy
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