Application of GIS Technology-Supported Cross Media Fusion Method Based on Deep Learning in Landscape Performance Evaluation.

GIS technology can provide reasonable and sustainable data support for landscape planning and ecological development and make wetland landscape planning consider the spatial layout of landscape and the optimal allocation of resources more. The key technologies of cross media intelligence mainly focus on intelligent information retrieval, analysis and reasoning, knowledge map construction, and intelligent storage. Convolutional neural network (CNN), as one of the representative algorithms of deep learning, plays an important role in retrieving landscape data and extracting image and text features across media. Further retrieval of media data, in-depth text processing, and image feature data extraction are realized by using deep learning technology, and comprehensive in-depth analysis is carried out by combining landscape plane images, three-dimensional images, and vector information in GIS technology. Provide quantitative information for the evaluation system of human landscape, economy, history, and region, so as to formulate a scientific and reasonable performance evaluation system.

NGF mediates protection of mesenchymal stem cells-conditioned medium against 2,5-hexanedione-induced apoptosis of VSC4.1 cells via Akt/Bad pathway.

It has been shown that the conditioned medium of bone mesenchymal stem cells (BMSC-CM) can inhibit apoptosis of neural cells exposed to 2,5-hexanedione (HD), but its protective mechanism remains unclear. To investigate the underlying mechanism, VSC4.1 cells were given HD and 5, 10 and 15% BMSC-CM (v/v) in the current experiment. Our data showed that BMSC-CM concentration-dependently attenuated HD-induced cell apoptosis. Moreover, BMSC-CM remarkably decreased the mitochondrial cytochrome c (Cyt C) release and the caspase-3 activity in HD-given VSC4.1 cells. Given a relatively high expression of NGF in BMSCs and BMSC-CM, we hypothesized that NGF might be an important mediator of the protection of BMSC-CM against apoptosis induced by HD. To verify our hypothesis, the VSC4.1 cells were administrated with NGF and anti-NGF antibody in addition to HD. As expected, NGF could perfectly mimic BMSC-CM's protective role and these beneficial effects were abolished by anti-NGF antibody intervention. To further explore its mechanism, inhibitors of TrkA and Akt were given to the VSC4.1 cells and NGF/Akt/Bad pathway turned out to be involved in anti-apoptotic role of BMSC-CM. Based on these findings, it was revealed that BMSC-CM beneficial role was mediated by NGF and relied on the Akt/Bad pathway.

Improved Adhesion Performance of Soy Protein-Based Adhesives with a Larch Tannin-Based Resin.

This study aimed to improve the bonding strength and water resistance of soy protein-based adhesives (SPAs) by modifying with larch tannin-based resins (TRs). This is especially important because of their eco-beneficial effects. The TR was characterized by Fourier Transform Infrared (FTIR) and Thermogravimetric/Derivative Thermogravimetric (TG/DTG) in order to demonstrate the formation of the self-crosslinking structure. Rheological properties, fracture morphology, solubility, and crosslinking density were characterized in detail. Three-ply poplar plywood was fabricated and the wet shear strength was measured. The experimental data showed that the addition of TR improved the moisture uptake, residual rate, and shear strength of SPA. This improvement was attributed to the crosslink reactions of TR with the relevant active functional groups of the side chains of soy protein molecules. The crosslinking structure joined with the TR self-crosslinking structure to form an interpenetrating network, which promoted a uniform and compact cured structure. The 5 wt % TR additions in the SPA was found to yield optimum results by improving the wet shear strength of the plywood by 105.4% to 1.13 MPa, which meets the interior-use plywood requirement. Therefore, the larch tannin could be applied in the modification of soy protein adhesive.

Fast Curing Bio-Based Phenolic Resins via Lignin Demethylated under Mild Reaction Condition.

Demethylation technique has been used to enhance lignin reactivity for preparation of phenolic resins. However, the demethylation efficiency and the demethylated lignin (DL) reactivity were still unsatisfactory. To improve the demethylation efficiency, alkali lignin was demethylated under different mild conditions using sodium sulfite as a catalyst. Lignin and DL were characterized by ¹H-NMR (nuclear magnetic resonance) and Fourier transform infrared (FT-IR) spectroscopy to determine the demethylation mechanism. With the demethylation of lignin, the methoxyl group content decreased from 1.93 m mol/g to 1.09 m mol/g, and the phenolic hydroxyl group content increased from 0.56 m mol/g to 0.82 m mol/g. These results revealed that methoxyl groups were attacked by SO3²-, and some methoxyl groups were converted to phenolic hydroxyl groups by a nucleophilic substitution reaction, generating DL with high reactivity. The chemical properties of lignin-based phenolic resins were studied by 13C-NMR and FT-IR spectroscopy, and their physical properties were also investigated. The results indicated that lignin-based phenolic resins exhibited faster curing rate and shorter gel time. In addition, the bonding strength increased from 0.92 MPa to 1.07 MPa, and the formaldehyde emission decreased from 0.58 mg/L to 0.22 mg/L after lignin demethylated at the optimum condition.

Physico-Chemical Properties of Soybean Meal-Based Adhesives Reinforced by Ethylene Glycol Diglycidyl Ether and Modified Nanocrystalline Cellulose.

An eco-friendly soybean meal-based adhesive (SM adhesive) was developed by incorporating ethylene glycol diglycidyl ether (EGDE) and nanocrystalline cellulose (NCC). In order to introduce epoxy groups, NCC was modified by KH560 (denoted as MNCC). The functional groups, thermal stability, and cross section of the resultant adhesive were characterized. Three-ply plywood was fabricated to measure the dry and wet shear strength of the adhesive. The experimental results showed that the epoxy groups on MNCC reacted with the carboxyl group of SM protein molecules, forming a crosslinking network and a ductile adhesive layer. As a result, compared with the SM adhesive modified by EGDE, the thermal stability of the adhesive with MNCC was improved and the wet shear strength was increased to 1.08 MPa.

A New Flexible Soy-Based Adhesive Enhanced with Neopentyl Glycol Diglycidyl Ether: Properties and Application.

Soy-based adhesives inherently possess low water resistance and brittleness, which limit their application on plywood fabrication. This investigation involves using a long chain cross-linker, neopentyl glycol diglycidyl ether (NGDE), to produce an intrinsic toughening effect to reduce the brittleness and improve the water resistance of a soybean meal⁻based adhesive. The solids content, viscosity, functional groups, fracture surface micrographs, and thermal stability of the adhesives were measured. Three-layer plywood was fabricated using the resultant adhesive, and the tensile shear strength of the plywood was measured. All adhesive properties were compared with a soybean meal/polyamidoamine-epichlorohydrin (PAE) adhesive and commercial melamine urea formaldehyde resin. The results showed that adding 6 g NGDE improved the water resistance of the soybean meal-based adhesive by 12.5%. This improvement is attributed to the following reasons: (1) a dense cross-linked network is formed by the chemical reaction between NGDE and protein molecules; (2) the toughness of the adhesive increases and a smooth and homogeneous fracture surface is created, which effectively prevents moisture intrusion; (3) the addition of NGDE increases the thermostability of the cured adhesive. The tensile shear strength of the plywood bonded with the soybean meal-based adhesive with 6 g NGDE was 286.2% higher than that without NGDE and attained 1.12 MPa, which was attributed to the reduction in the adhesive's viscosity, and the improvement in the water resistance and toughness of the adhesive. The tensile shear strength of the plywood bonded with 6 g NGDE was 19.1% higher than that with 6 g PAE and was similar to the MUF resin, which validated the novel adhesive being suitable for use as an industrial plywood adhesive.

Synthesis and Mechanism of Metal-Mediated Polymerization of Phenolic Resins.

Phenol-formaldehyde (PF) resin is a high performance adhesive, but has not been widely developed due to its slow curing rate and high curing temperature. To accelerate the curing rate and to lower the curing temperature of PF resin, four types of metal-mediated catalysts were employed in the synthesis of PF resin; namely, barium hydroxide (Ba(OH)2), sodium carbonate (Na2CO3), lithium hydroxide (LiOH), and zinc acetate ((CH3COO)2Zn). The cure-acceleration effects of these catalysts on the properties of PF resins were measured, and the chemical structures of the PF resins accelerated with the catalysts were investigated by using Fourier transform infrared (FT-IR) spectroscopy and quantitative liquid carbon-13 nuclear magnetic resonance (13C NMR). The results showed that the accelerated efficiency of these catalysts to PF resin could be ordered in the following sequence: Na2CO3 > (CH3COO)2Zn > Ba(OH)2 > LiOH. The catalysts (CH3COO)2Zn and Na2CO3 increased the reaction activity of the phenol ortho position and the condensation reaction of ortho methylol. The accelerating mechanism of (CH3COO)2Zn on PF resin is probably different from that of Na2CO3, which can be confirmed by the differences in the differential thermogravimetric (DTG) curve and thermogravimetric (TG) data. Compared to the Na2CO3-accelerated PF resin, the (CH3COO)2Zn-accelerated PF resin showed different peaks in the DTG curve and higher weight residues. In the synthesis process, the catalyst (CH3COO)2Zn may form chelating compounds (containing a metal-ligand bond), which can promote the linkage of formaldehyde to the phenolic hydroxyl ortho position.

A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia.

Hyperprolactinemia is a common adverse effect that occurs as a result of antipsychotic therapies, which often results in discontinuation. Empirical evidence has shown that some herbal medicines have suppressive effects on prolactin (PRL) hyperactivities. This study was designed to compare the herbal preparation called Peony-Glycyrrhiza Decoction (PGD) with bromocriptine (BMT), a dopamine agonist widely used for PRL-secreting disorders, in the treatment of risperidone-induced hyperprolactinemia. Twenty schizophrenic women who were under risperidone maintenance treatment, diagnosed with hyperprolactinemia (serum PRL levels >50 mug/L), and currently experiencing oligomenorrhea or amenorrhea were selected for the study. Subjects were randomized to additional treatment with PGD (45 g/d) followed by BMT (5 mg/d) or BMT followed by PGD at the same doses for 4 weeks each, with an interval of 4-week washout period between 2 treatment sessions. The severity of psychotic symptoms, adverse events, serum PRL, estradiol, testosterone, and progesterone levels were examined at baseline and end point. Peony-Glycyrrhiza Decoction treatment produced a significant baseline-end point decrease in serum PRL levels, without exacerbating psychosis and changing other hormones, and the decreased amplitudes were similar to those of BMT (24% vs 21%-38%). Moreover, there was a significantly greater proportion of patients during PGD treatment than BMT treatment showing improvements on adverse effects associated with hyperprolactinemia (56% vs 17%, P = 0.037). These results suggest that the herbal therapy can yield additional benefits while having comparable efficacy in treating antipsychotic-induced hyperprolactinemia in individuals with schizophrenia.

Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells.

Amyloid beta-protein (A beta) is a pivotal pathological factor in Alzheimer's disease (AD). Tenuigenin, extracted from the Chinese herb Polygala tenuifolia, seems to ameliorate the reduction in cholinergic function on rat models induced by A beta. To examine this therapeutic effect, we tested whether Tenuigenin could inhibit secretion of A beta in neuroblastoma cells stably transfected with two amyloid precursor protein (APP) constructs: the APP695 cDNA (SH-SY5Y APP695) and the C-terminal 99 amino acid residues of APP plus the signal peptide (SH-SY5Y SPA4CT). Tenuigenin inhibited the secretion of A beta and the C-terminal 99 amino acids of APP (C99) in SH-SY5Y APP695 cells, but did not change the A beta and C99 levels in SH-SY5Y SPA4CT cells. Fluorescence Resonance Energy Transfer (FRET) assays showed that Tenuigenin inhibited the proteolytic activities of BACE1 (beta-secretase) on its substrate in vitro. In addition, Tenuigenin did not demonstrate any cytotoxic effects, nor did it affect APP mRNA expression, holoAPP synthesis or sAPP alpha secretion. Our data suggest that Tenuigenin can inhibit the secretion of A beta in SH-SY5Y APP 695 cells via BACE1 inhibition. Taken together, these results suggest that Tenuigenin may be worthy of future study as an anti-AD drug.