Research progress on direct borohydride fuel cells.

The rapid development of industry has accelerated the utilization and consumption of fossil energy, resulting in an increasing shortage of energy resources and environmental pollution. Therefore, it is crucial to explore new energy storage devices using renewable and environment-friendly energy as fuel. Direct borohydride fuel cells (DBFCs) are expected to be a feasible and efficient energy storage device by virtue of the read availability of raw materials, non-toxicity of products, and excellent operational stability. Moreover, while utilizing H2O2 as an oxidant, a significant theoretical energy density of 17 kW h kg-1 can be achieved, indicating the broad application prospect of DBFCs in long-range operation and oxygen-free environment. This review summarizes the research progress on DBFCs in term of reaction kinetics, electrode materials, membrane materials, architecture, and electrolytes. In addition, we predict the future research challenges and feasible research directions, considering both performance and cost. We hope this review will help guide future studies on DBFCs.

State-of-the-Art Two-Dimensional Metal Phosphides for High Performance Lithium-ion Batteries: Progress and Prospects.

Lithium-ion batteries (LIBs) with high energy density, long cycle life and safety have earned recognition as outstanding energy storage devices, and have been used in extensive applications, such as portable electronics and new energy vehicles. However, traditional graphite anodes deliver low specific capacity and inferior rate performance, which is difficult to satisfy ever-increasing demands in LIBs. Very recently, two-dimensional metal phosphides (2D MPs) emerge as the cutting-edge materials in LIBs due to their overwhelming advantages including high theoretical capacity, excellent conductivity and short lithium diffusion pathway. This review summarizes the up-to-date advances of 2D MPs from typical structures, main synthesis methods and LIBs applications. The corresponding lithium storage mechanism, and relationship between 2D structure and lithium storage performance is deeply discussed to provide new enlightening insights in application of 2D materials for LIBs. Several potential challenges and inspiring outlooks are highlighted to provide guidance for future research and applications of 2D MPs.

Design of a high speed rat whiskers tracking and symmetry analysis system based on FPGA.

This paper presents a high-speed rat whisker tracking and symmetry analysis system based on FPGA. The system utilizes high-speed image sensors recording rat face videos at 120 and 1000 fps. The Xilinx Ultra96 single computer board is chosen as the platform to implement the system's processing system (PS) and the programmable logic (PL) part. The PL part is responsible for high-speed image processing and whisker tracking, while the PS part analyzes the symmetry of rat face using the tracking results from the PL part. With a processing speed FoM of 118.5 fps/GHz on the Xilinx Ultra96 single computer board and 275.47 fps/GHz on a laptop with Intel Core i5-11500T@1.5GHz, the presented system achieves excellent performance. The proposed whisker detection method has a precision of 98.2% when a threshold with a 4-degree error is selected, with an average error angle of 0.98 degrees across more than 10,000 video frames. Moreover, the proposed system is capable of local video processing within millisecond delays. These results demonstrate the feasibility of developing a high-speed, accurate, and efficient whisker tracking and symmetry analysis system for rat behavior research.

A PCA Based Artifact Removal Algorithm for Neural Signal Acquisition with kS/s Sampling Rate.

The contamination of stimulus artifacts during Deep Brain Stimulation (DBS) brings challenges to the signal processing, especially when the ratio of the kS/s sampling rate to the stimulation frequency is not an integer. In this work we study to deal with this problem. A transfer function is built to describe the relationship between the stimulation signal and the artifact at the acquisition site. A principal component analysis (PCA) based linear regression algorithm for eliminating the artifact is proposed. The algorithm can be used for the artifact removal with low sampling rate of the neural signal. Higher than 60% correlation coefficient of the artifact-free signal and the predetermined self-generated signal is achieved when the artifact is 60dB larger than the predetermined signal. The numerical recipe for the critical algorithm is also proposed, lowering the complexity from cubic degree to square degree.

Soft and stretchable organic bioelectronics for continuous intraoperative neurophysiological monitoring during microsurgery.

In microneurosurgery, it is crucial to maintain the structural and functional integrity of the nerve through continuous intraoperative identification of neural anatomy. To this end, here we report the development of a translatable system leveraging soft and stretchable organic-electronic materials for continuous intraoperative neurophysiological monitoring. The system uses conducting polymer electrodes with low impedance and low modulus to record near-field action potentials continuously during microsurgeries, offers higher signal-to-noise ratios and reduced invasiveness when compared with handheld clinical probes for intraoperative neurophysiological monitoring and can be multiplexed, allowing for the precise localization of the target nerve in the absence of anatomical landmarks. Compared with commercial metal electrodes, the neurophysiological monitoring system allowed for enhanced post-operative prognoses after tumour-resection surgeries in rats. Continuous recording of near-field action potentials during microsurgeries may allow for the precise identification of neural anatomy through the entire procedure.

Hydrogel Nanoarchitectonics of a Flexible and Self-Adhesive Electrode for Long-Term Wireless Electroencephalogram Recording and High-Accuracy Sustained Attention Evaluation.

Hydrogels are ideal building blocks to fabricate the next generation of electrodes for acquiring high-quality physiological electrical signals, for example, electroencephalography (EEG). However, collection of EEG signals still suffers from electrode deformation, sweating, extensive body motion and vibration, and environmental interference. Herein, polyvinyl alcohol and polyvinylpyrrolidone are selected to prepare a hydrogel network with tissue-like modulus and excellent flexibility. Additionally, polydopamine nanoparticles, obtained by polydopamine peroxidation, are integrated into the hydrogel to endow them with higher transparency, higher self-adhesion, and lower impedance. Consequently, a multichannel and wirelessly operated hydrogel electrode can establish a conformal and stable interface with tissue and illustrate high channel uniformity, low interfacial contact impedance, low power noise, long-term stability, and a tolerance to sweat and motion. Furthermore, the hydrogel electrode shows the unprecedented ability to classify the recorded high-quality prefrontal EEG signals into seven-category sustained attention with high accuracy (91.5%), having great potential applications in the assessment of human consciousness and in multifunctional diagnoses.

Effects of oxygen content on gaseous and solid products during molten salt oxidation of cation exchange resins.

Molten salt oxidation (MSO) is an advanced method for waste resins treatment; nevertheless, the research about gas product variations of resins under different stoichiometric air feed coefficient (α) is rare. The optimal working condition of hazardous waste disposal is obtained through thermodynamic equilibrium calculation, and the method to improve the treatment efficiency is found to guide the optimization of the actual experiment. In this paper, Fact Sage was used to calculate the oxidation products of cation exchange resins (CERs) at different temperatures and α, focusing on the similarities and differences through the contents of CO, CH4, CO2, and SO2 during the oxidation of CERs, the MSO of CERs, and the theoretical calculation. The results indicated that the gas products of the calculation and reality of the oxidation process of CERs are quite different, while the CO contents of CERs during MSO are close to the calculated values. The main reason for this consequence is that in the oxidation process of CERs, the S in the sulfonic acid group will form thermally stable C-S with the styrene-divinylbenzene skeleton. Moreover, the introduction of carbonate can promote the destruction of C-S and absorb SO2 as sulfate, weakening the influence of C-S on the oxidation products of CERs. The gas chromatograph results indicated that the SO2 content is reduced from 0.66% in the process of CERs oxidation to 0.28% in MSO of CERs. When 1.25 times stoichiometric air feed coefficient is fed, the sulfate content in the carbonate is the highest at 900 °C, which is 23.4%.

Design of a Parkinsonian Biomarkers Combination Optimization Method Using Rodent Model.

Adaptive Deep Brain Stimulation (aDBS) has been proposed in literature to avoid the negative consequences associated with the continuous stimulation delivered through traditional deep brain stimulation. This work seeks to determine a group of neural biomarkers that a classification algorithm could use on an aDBS device using rodent animal models. The neural activities were acquired from the primary motor cortex of four Parkinsonian model rats and four healthy rats from a control group. To overcome the variability introduced from the small rat sample size, this work proposes a novel method for combining and running Genetic Feature Selection and Forward Stepwise Feature Selection in an environment where classification accuracy varies greatly based on how the folds are organized before cross-validation. Three separate classification algorithms, Logistic Regression, k-Nearest Neighbor, and Random Forest are used to verify the proposed method. For Logistic Regression, the set of Alpha Power (7-12 Hz), High Beta Power (20-30 Hz), and 55-95 Hz Gamma Power shows the best performance in classification. For k-Nearest Neighbor, the characterizing features are Low Beta Power (12-20 Hz), High Beta Power, All Beta Power (12-30 Hz), 55-95 Hz Gamma Power, and 95-105 Hz Gamma Power. For Random Forest, they are High Beta Power, All Beta Power, 55-95 Hz Gamma Power, 95-105 Hz Gamma Power, and 300-350 Hz High-Frequency Oscillations Power. With the selected feature set, experimental results show an increasing classification accuracy from 59.08% to 77.69% for Logistic Regression, from 49.53% to 73.44% for k-Nearest Neighbor, and from 54.10% to 71.15% for Random Forest. Clinical Relevance- This experiment provides a method for determining the most effective biomarkers from a larger set for classifying Parkinsonian behavior for an aDBS device.

A flexible and highly sensitive organic electrochemical transistor-based biosensor for continuous and wireless nitric oxide detection.

As nitric oxide (NO) plays significant roles in a variety of physiological processes, the capability for real-time and accurate detection of NO in live organisms is in great demand. Traditional assessments of NO rely on indirect colorimetric techniques or electrochemical sensors that often comprise rigid constituent materials and can hardly satisfy sensitivity and spatial resolution simultaneously. Here, we report a flexible and highly sensitive biosensor based on organic electrochemical transistors (OECTs) capable of continuous and wireless detection of NO in biological systems. By modifying the geometry of the active channel and the gate electrodes of OECTs, devices achieve optimum signal amplification of NO. The sensor exhibits a low response limit, a wide linear range, high sensitivity, and excellent selectivity, with a miniaturized active sensing region compared with a conventional electrochemical sensor. The device demonstrates continuous detection of the nanomolar range of NO in cultured cells for hours without significant signal drift. Real-time and wireless measurement of NO is accomplished for 8 d in the articular cavity of New Zealand White rabbits with anterior cruciate ligament (ACL) rupture injuries. The observed high level of NO is associated with the onset of osteoarthritis (OA) at the later stage. The proposed device platform could provide critical information for the early diagnosis of chronic diseases and timely medical intervention to optimize therapeutic efficacy.

Catalytic effect of cesium on the oxidation behavior of cation exchange resins in Li2CO3-Na2CO3-K2CO3 melt.

After the treatment of liquid radioactive waste, there is a certain amount of Cs in the waste resin, and these Cs-doped resins are prone to volatilize during the thermal treatment process and cause radionuclide leakage. The molten salt oxidation (MSO) can effectively prevent the volatilization of toxic metal, especially the volatilization of Cs. Under nitrogen and air conditions, it is found that the oxidation behavior between Cs-doped and clean cation exchange resins (CERs) is quite different. In the presence of oxygen and molten carbonate salt, Cs2CO3 is generated by the destruction of functional groups in Cs-doped CERs. The Cs2CO3 in Na2CO3-K2CO3-Li2CO3 reacts with oxygen to form Li2O2, which reduces the content of S in residue from 26.33 to 13.38% in air conditions at 400 °C and promotes the generation of sulfate in the molten carbonate salt. The elements Cs and S in the Cs doped CERs spontaneously form thermally stable Cs2SO4 in the molten carbonate salt.

Efficacy and safety of 5% glycolic acid-based Gel essence in the treatment of mild to moderate acne.

The efficacy and safety of commercial low-concentration glycolic acid products on acne were evaluated by recruiting volunteers accompanying mild to moderate acne of different ages and genders, which is a clinical practice for acne. We recruited a total of 30 volunteers according to the inclusion criteria, conducting clinical evaluation and skin physiological index testing, VISIA skin analysis, distributing products, and informing the trial method. Clinical testing and assessment will be carried out in weeks 0, 1, 2, and 4. 27 acne volunteers finished the entire trial. After 4 weeks of using low-concentration glycolic acid products, most subjects experienced a significant improvement in their skin lesions and the GAGS score. At the same time, the VISIA test showed that the subjects had an obvious amelioration in facial porphyrins, which was statistically significant, and there was a slight improvement in residual spots and erythema. The skin physiological indexes showed that the skin hydration value increased from 236.2 ± 98.05 to 278.2 ± 90.26 after 14 days. At the end of the test, the skin hydration value dropped to 234.6 ± 81.88. Regarding the melanin and erythema, the value decreased in the 4th week significantly. Repeated use of 5% low-concentration glycolic acid improves the appearance and chromaticity of the treatment site. It increases the brightness L* and reduces the redness a*. This study shows that low concentrations of glycolic acids have a good effect on the treatment of mild to moderate acne. It may pay the way to carry out further large-scale clinical research.

Molten salt/liquid metal extraction: Electrochemical behaviors and thermodynamics properties of La, Pr, U and separation factors of La/U and Pr/U couples in liquid gallium cathode.

The electrochemical behavior of lanthanides (La, Pr) and actinide (U) on inert W and liquid Ga electrodes in LiCl-KCl molten salt as well as their related thermodynamic properties were experimentally determined for further Lns/Ans separation. The results indicate that the reductions of La3+ and Pr3+ in LiCl-KCl melts are both one-step process with three electrons exchanged, and the reactions are quasi-reversible processes at low scan rate. Temperature dependencies of apparent standard redox potentials of La(Ga), Pr(Ga) and U(Ga) alloys were determined by open-circuit chronopotentiometry versus Cl-/Cl2 reference electrode. The activity and activity coefficients of lanthanum, praseodymium and uranium on the liquid Ga electrode in the temperature interval 723-813 K were calculated. The separation factors for La/U and Pr/U on the liquid Ga electrode in the molten salt were determined by logθU/La=-10.39+11440.69T±0.0125 and logθU/Pr=-5.84+7763.27T±0.07. The separation factors of La/U and Pr/U on the liquid Ga electrode indicate that lower temperature should be more effective for separating uranium.

MOF-derived electrochemical catalyst Cu-N/C for the enhancement of amperometric oxygen detection.

Electrochemical sensors using ionic liquids as electrolytes for oxygen detection are now getting more and more attention. Recently, an ionic liquid combined with an electrochemically active catalyst system has become popular for boosting the sensing performance of oxygen sensors. In this work, the imidazolyl-based ionic liquid 1-butyl-2,3-dimethylimidazole bis((trifluoromethyl)sulfonyl)imide [Bmmim][TFSI] is first prepared by a facile two-step method. Subsequently, a transition metal and N-codoped porous carbon oxygen reduction electrochemical catalyst Cu-N/C is synthesized by calcining the Cu-doped ZIF-8 precursor and then blending it in different ratios with the ionic liquid [Bmmim][TFSI] as composite electrolytes for oxygen detection. The composite electrolyte Cu-N/C/[Bmmim][TFSI] exhibits increased responses in cyclic voltammetry (CV) and chronoamperometry (CA) relative to that of the pure ionic liquid. Furthermore, the CV and CA data show that 6% Cu-N/C/[Bmmim][TFSI] has the optimum oxygen sensing response with an enhanced reduction peak current, a sensitivity of 0.1678 µA/[% O2] and a good linear fitting coefficient of 0.9991. In conclusion, the results confirm the success of using Cu-N/C as an electrochemical catalyst composed of the Cu-N/C/[Bmmim][TFSI] electrolyte for improving the responsivity, stability and sensitivity towards a wide range of oxygen concentrations.

Electrochemical preparation and properties of a Mg-Li-Y alloy via co-reduction of Mg(ii) and Y(iii) in chloride melts.

Mg-Li based alloys have been widely used in various fields. However, the widespread use of Mg-Li based alloys were restricted by their poor properties. The addition of rare earth element in Mg-Li can significantly improve the properties of alloys. In the present work, different electrochemical methods were used to investigate the electrochemical behavior of Y(iii) on the W electrode in LiCl-KCl melts and LiCl-KCl-MgCl2 melts. In LiCl-KCl melts, typical cyclic voltammetry was used to study the electrochemical mechanism and thermodynamic parameters for the reduction of Y(iii) to metallic Y. In LiCl-KCl-MgCl2 melts, the formation mechanism of Mg-Y intermetallic compounds was investigated, and the results showed that only one kind of Mg-Y intermetallic compound was formed under our experimental conditions. Mg-Li-Y alloys were prepared via galvanostatic electrolysis, and XRD and SEM equipped with EDS analysis were used to analyze the samples. Because of the restrictions of EDS analysis, ICP-AES was used to analyze the Li content in Mg-Li-Y alloys. The microhardness and Young's modulus of the Mg-Li-Y alloys were then evaluated.

Fabrication of Conductive, Adhesive, and Stretchable Agarose-Based Hydrogels for a Wearable Biosensor.

Herein, a strategy is proposed to prepare a conductive, self-adhesive, and stretchable agarose gel with the merits of distinct heat resistance, freeze resistance, and long-term moisture retention. To endow the gels with conductivity, monodisperse carbon nanotubes modified by polydopamine are introduced into the gel networks, which promote both conductivity and mechanical strength of the gels. Meanwhile, further addition of glycerol enhances excellent stretchability as well as heating/freezing tolerability and moisture retention of the gels. A wearable biosensor based on the gel is fabricated to record body motions precisely with good biocompatibility, which benefits the development of smart wearable devices.

Design of a Low Noise Bio-Potential Recorder With High Tolerance to Power-Line Interference Under 0.8 V Power Supply.

A bio-potential recorder working under 0.8 V supply voltage with a tunable low-pass filter is proposed in this paper. The prototype is implemented in TSMC 180 nm CMOS technology, featuring a power consumption of 2.27  µW, while preserving a high tolerance of power-line interference (PLI) up to 600 m Vpp, a common-mode rejection ratio (CMRR) of higher than 100 dB, a THD of -65.5 dB, and a noise density of 50 nV/ √{Hz} by employing four new techniques, including 1) low noise chopper modulator, 2) feedback loop based common-mode cancellation loop (CMCL), 3) offset cancellation loop (OCL) with PMOS backgate control scheme, and 4) a very-lower transconductance (VLT) operational transconductance amplifier (OTA) using in the DC-servo-loop (DSL). The measured mid-band gain is 43.3 dB with a high-pass cut-off frequency of 1.2 Hz. The low-pass cut-off frequency can be configured from 650 Hz to 7.5 kHz. The measured input-referred integrated noise is 1.2 uVrms in the frequency band of 1-650 Hz and 4.1 uVrms in the 1 Hz-7.5 kHz frequency band, respectively, leading to a power efficiency factor (PEF) of 7.49 and 7.59.

Electrical stimulation of the endopiriform nucleus attenuates epilepsy in rats by network modulation.

OBJECTIVE: Neuromodulatory anterior thalamic deep brain stimulation (DBS) is an effective therapy for intractable epilepsy, but few patients achieve complete seizure control with thalamic DBS. Other stimulation sites may be considered for anti-seizure DBS. We investigated bilateral low-frequency stimulation of the endopiriform nuclei (LFS-EPN) to control seizures induced by intracortically implanted cobalt wire in rats. METHODS: Chronic epilepsy was induced by cobalt wire implantation in the motor cortex unilaterally. Bipolar-stimulating electrodes were implanted into the EPN bilaterally. Continuous electroencephalography (EEG) was recorded using electrodes placed into bilateral motor cortex and hippocampus CA1 areas. Spontaneous seizures were monitored by long-term video-EEG, and behavioral seizures were classified based on the Racine scale. Continuous 1-Hz LFS-EPN began on the third day after electrode implantation and was controlled by a multi-channel stimulator. Stimulation continued until the rats had no seizures for three consecutive days. RESULTS: Compared with the control and sham stimulation groups, the LFS-EPN group experienced significantly fewer seizures per day and the mean Racine score of seizures was lower due to fewer generalized seizures. Ictal discharges at the epileptogenic site had significantly reduced theta band power in the LFS-EPN group compared to the other groups. INTERPRETATION: Bilateral LFS-EPN attenuates cobalt wire-induced seizures in rats by modulating epileptic networks. Reduced ictal theta power of the EEG broadband spectrum at the lesion site may be associated with the anti-epileptogenic mechanism of LFS-EPN. Bilateral EPN DBS may have therapeutic applications in human partial epilepsies.

A flexible and physically transient electrochemical sensor for real-time wireless nitric oxide monitoring.

Real-time sensing of nitric oxide (NO) in physiological environments is critically important in monitoring neurotransmission, inflammatory responses, cardiovascular systems, etc. Conventional approaches for NO detection relying on indirect colorimetric measurement or built with rigid and permanent materials cannot provide continuous monitoring and/or require additional surgical retrieval of the implants, which comes with increased risks and hospital cost. Herein, we report a flexible, biologically degradable and wirelessly operated electrochemical sensor for real-time NO detection with a low detection limit (3.97 nmol), a wide sensing range (0.01-100 µM), and desirable anti-interference characteristics. The device successfully captures NO evolution in cultured cells and organs, with results comparable to those obtained from the standard Griess assay. Incorporated with a wireless circuit, the sensor platform achieves continuous sensing of NO levels in living mammals for several days. The work may provide essential diagnostic and therapeutic information for health assessment, treatment optimization and postsurgical monitoring.

Water-locking molecule-assisted fabrication of nature-inspired Mg(OH)2 for highly efficient and economical uranium capture.

With the depletion of uranium terrestrial deposits, researchers have focused on the development of adsorbents to extract radioactive uranium from seawater/wastewater. However, the artificial manipulation of adsorbents for the cost-effective extraction of radioactive uranium from large numbers of water samples is still significantly challenging. Herein, a facile yet versatile stepwise strategy has been reported for the fabrication of adsorbents. Magnesium hydroxide (Mg(OH)2) was fabricated via the in situ conversion of a natural ore powder (magnesite), whose unique internal pore structure is highly suitable for the development of highly efficient sorbents. The coordination interaction of the synthesized adsorbent with uranium was enhanced by further introducing inexpensive molecules with water-locking properties, which resulted in superior extraction capacity and low production cost. After careful calculation, the cost per kilogram of the adsorbent was found to be about $0.21. The adsorption behaviors of the synthesized adsorbent CMC-PAM/Mg(OH)2 were investigated by batch adsorption, flow-through column adsorption (in laboratory), and field adsorption experiments in natural seawater and river. Representatively, CMC-PAM/Mg(OH)2 was exceptional in extracting uranium not only at high concentrations with sufficient capacities in a wide pH range (1584.67 mg g-1 and 454.55 mg g-1 at pH = 5 and pH = 8, respectively), but also in trace quantities including uranium in a flow-through column (55.68 mg g-1), natural seawater (8.6 mg g-1), and river (6.7 mg g-1). Inspired by this excellent performance, the effects of competitive ions on the selective adsorption of uranium by CMC-PAM/Mg(OH)2 in simulated wastewater and seawater environments were further studied. Using a combination of FTIR spectroscopic and XPS studies, it was revealed that the amine and hydroxyl groups enhanced the overall uranyl affinity of the CMC-PAM/Mg(OH)2 composite.

Design of a Flexible Wearable Smart sEMG Recorder Integrated Gradient Boosting Decision Tree Based Hand Gesture Recognition.

This paper proposed a wearable smart sEMG recorder integrated gradient boosting decision tree (GBDT) based hand gesture recognition. A hydrogel-silica gel based flexible surface electrode band is used as the tissue interface. The sEMG signal is collected using a neural signal acquisition analog front end (AFE) chip. A quantitative analysis method is proposed to balance the algorithm complexity and recognition accuracy. A parallel GBDT implementation is proposed featuring a low latency. The proposed GBDT based neural signal processing unit (NSPU) is implemented on an FPGA near the AFE. A RF module is used for wireless communication. A hand gesture set including 12 gestures is designed for human-computer interaction. Experimental results show an overall hand gesture recognition accuracy of 91%.