Copper(II)-Catalyzed Alkene Aminosulfonylation with Sodium Sulfinates For the Synthesis of Sulfonylated Pyrrolidones.

A copper-catalyzed direct aminosulfonylation of unactivated alkenes with sodium sulfinates for the efficient synthesis of sulfonylated pyrrolidones is described. This reaction features good functional group tolerance and wide substrate scope, providing an efficient and straightforward protocol to access this kind of pyrrolidones. Moreover, preliminary mechanistic investigations disclosed that a free-radical pathway might be invovled in the process.

Selective O-Cyclization of N-Methoxy Aryl Amides with CH2Br2 or 1,2-DCE via Palladium-Catalyzed C-H Activation.

A selective O-cyclization of N-methoxy aryl amides with CH2Br2 or 1,2-DCE (1,2-dichloroethane) via palladium-catalyzed C-H activation has been described. New C(sp3)-O and C(sp2)-C(sp3) bonds are forged simultaneously with the assistance of an N-methoxy amide group, and good functional group tolerance in substrates is observed. Preliminary mechanistic investigations show that the process may involve a five-membered palladacycle intermediate.