Predicting survival in patients with buccal cancer: A study based on SEER database and external validation in China.

OBJECTIVE: Buccal mucosa cancer (BMC) is one of the most common oral cancers and has poor prognosis. The study aimed to develop and validate nomograms for predicting the 1-, 3-, and 5-year overall survival (OS) and cancer-specific survival (CSS) of BMC patients. METHODS: We collected and reviewed information on BMC patients diagnosed between 2004 and 2019 from the Surveillance Epidemiology and End Results database. Two nomograms were developed and validated to predict the OS and CSS based on predictors identified by univariate and multivariate Cox regression. An extra external validation was further performed using data from Sun Yat-sen Memorial Hospital (SYSMH). RESULTS: A total of 3154 BMC patients included in this study were randomly assigned to training and validation groups in a 2:1 ratio. Independent prognostic predictors were identified, confirmed, and fitted into nomograms for OS and CSS, respectively. The C-indices are 0.767 (Training group OS), 0.801 (Training group CSS), 0.763 (Validation group OS), and 0.781 (Validation group OS), respectively. Moreover, the nomograms exhibited remarkable precision in forecasting and significant clinical significance, as evidenced by receiver operating characteristic (ROC) curves, calibration curves, and decision curve analyses (DCA). The final validation using our data from SYSMH also showed high accuracy and substantial clinical benefits within the nomograms. The C-indices are 0.849 (SYSMH group OS) and 0.916 (SYSMH group CSS). These indexes are better than tumor, node, and metastasis stage based on prediction results. CONCLUSIONS: The nomograms developed with great performance predicted 1-, 3-, and 5-year OS and CSS of BMC patients. Use of the nomograms in clinical practices shall bring significant benefits to BMC patients.

Research on scientific sports training of students majoring in physical education / Pesquisa científica sobre o treinamento esportivo de alunos do curso de educação física / Investigación sobre la formación científico-deportiva de estudiantes de la carrera de educación física

ABSTRACT Introduction: The organization of high-level sports teams in colleges and universities is an important measure for my country's competitive sports to break the traditional monopoly and monopoly pattern and go to the market and society in an all-around way. It helps to improve the cultural quality of Chinese athletes and cultivate new sports talents for comprehensive development. It can make full use of universities' multidisciplinary and high-tech advantages, increase the technological content of competitive training, and accelerate the improvement of sports level. Objective: This article intends to take the diving team as an example to explain the role and significance of scientific training in developing competitive sports in my country's ordinary colleges and universities and put forward suggestions for the establishment, organization, and implementation of scientific training. Methods: The scientific research support system used in the thesis includes: physiological and biochemical monitoring, health and sports injury monitoring, nutrition and weight monitoring, psychological consultation and monitoring, technical training support system, training quality management system, physical training support system, and athlete training database. Results: The in-depth research on diving training focuses on: (1) the detection and evaluation of diving technique training; (2) the training of divers' specific strength qualities; (3) the monitoring of nutrition and weight of female athletes; (4) Pre-match psychological training for outstanding diving athletes. Conclusions: The diving team's training shows that scientific and systematic training is an important guarantee for high-level student-athletes training in ordinary universities in my country. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMO Introdução: A organização de equipes esportivas de alto nível em faculdades e universidades é uma medida importante para que os esportes competitivos em meu país quebrem o padrão tradicional de monopólio e entrem no mercado e na sociedade de maneira abrangente. Ajuda a melhorar a qualidade cultural dos atletas chineses e a cultivar novos talentos esportivos para um desenvolvimento integral. Pode tirar o máximo proveito das vantagens multidisciplinares e de alta tecnologia das universidades, aumentar o conteúdo tecnológico do treinamento competitivo e acelerar a melhoria do nível esportivo. Objetivo: Este artigo visa tomar a equipe de mergulho como exemplo para explicar o papel e a importância da formação científica no desenvolvimento dos esportes competitivos em faculdades e universidades comuns do meu país e apresentar sugestões para o estabelecimento, organização e implementação da formação científica. Métodos: O sistema de apoio à investigação científica utilizado na tese inclui: monitorização fisiológica e bioquímica, monitorização de lesões na saúde e desportivas, monitorização da nutrição e peso, consulta e monitorização psicológica, sistema de apoio técnico à formação, sistema de gestão da qualidade da formação, apoio à formação física sistema e banco de dados de treinamento de atletas. Resultados: A pesquisa aprofundada sobre o treinamento em mergulho concentra-se em: (1) detecção e avaliação do treinamento em técnicas de mergulho; (2) treinar as qualidades específicas de força dos mergulhadores; (3) monitorar a nutrição e o peso dos atletas; (4) Treinamento psicológico pré-jogo para atletas de mergulho de destaque. Conclusões: O treinamento da equipe de mergulho mostra que o treinamento científico e sistemático é uma garantia importante para a formação de alunos-atletas de alto nível em universidades comuns de meu país. Nível de evidência II; Estudos terapêuticos: investigação dos resultados do tratamento.

RESUMEN Introducción: La organización de equipos deportivos de alto nivel en colegios y universidades es una medida importante para que el deporte competitivo de mi país rompa el patrón tradicional de monopolio e ingrese al mercado y a la sociedad de manera integral. Ayuda a mejorar la calidad cultural de los atletas chinos y a cultivar nuevos talentos deportivos para un desarrollo integral. Puede aprovechar al máximo las ventajas multidisciplinarias y de alta tecnología de las universidades, aumentar el contenido tecnológico de la formación competitiva y acelerar la mejora del nivel deportivo. Objetivo: Este artículo pretende tomar al equipo de buceo como ejemplo para explicar el papel y la importancia de la formación científica en el desarrollo de deportes competitivos en los colegios y universidades ordinarios de mi país y presentar sugerencias para el establecimiento, organización e implementación de la formación científica. Métodos: El sistema de apoyo a la investigación científica utilizado en la tesis incluye: seguimiento fisiológico y bioquímico, seguimiento de la salud y lesiones deportivas, seguimiento de la nutrición y el peso, consulta y seguimiento psicológico, sistema de apoyo al entrenamiento técnico, sistema de gestión de la calidad del entrenamiento, sistema de apoyo al entrenamiento físico, y base de datos de entrenamiento de atletas. Resultados: La investigación en profundidad sobre el entrenamiento de buceo se enfoca en: (1) la detección y evaluación del entrenamiento de técnicas de buceo; (2) el entrenamiento de las cualidades de fuerza específicas de los buzos; (3) el seguimiento de la nutrición y el peso de las atletas; (4) Entrenamiento psicológico previo al partido para atletas de buceo destacados. Conclusiones: La formación del equipo de buceo muestra que la formación científica y sistemática es una garantía importante para la formación de estudiantes-deportistas de alto nivel en las universidades ordinarias de mi país. Nivel de evidencia II; Estudios terapéuticos: investigación de los resultados del tratamiento.

Effects of aerobic exercise on TC, HDL-C, LDL-C and TG in patients with hyperlipidemia: A protocol of systematic review and meta-analysis.

BACKGROUND: With the development of the social level and the improvement of living standards, people's dietary structure changes in the direction of high blood fat, high sugar and high fever, which leads to the occurrence of many diseases.Long-term increase in blood lipids can easily cause cholesterol to invade the walls of large blood vessels, deposit and accumulate, and promote the proliferation of smooth muscle cells and fibroblasts in the arterial intima, leading to coronary heart disease and atherosclerosis (AS) and other cardiovascular and cerebrovascular diseases. METHODS: Electronic databases including Google Scholar, PubMed, Web of Science(WOS), the Cochrane Library, EMBASE and VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang. These databases will be searched to identify randomized controlled trials published January 1, 1980, and January 20, 2021. Language is limited with English and Chinese. We will use the standards provided in Cochrane Handbook 5.3.0 for quality assessment and risk assessment, and use Revman 5.3 software for meta-analysis. The primary outcomes are mainly evaluated by total cholesterol and triglyceride. CONCLUSION: The results of this study can provide a beneficial basis for the improvement of total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and triglyceride in patients with hyperlipidemia.

Peroneus Longus Tendon Autograft is a Safe and Effective Alternative for Anterior Cruciate Ligament Reconstruction.

The ipsilateral peroneus longus tendon (PLT) was utilized as an autograft for anterior cruciate ligament (ACL) reconstruction of patients with acute ACL rupture and grade III medial collateral ligament (MCL) injury. We investigated the efficacy and safety of this alternative autograft compared with autologous hamstring tendon (HT). Biomechanical testing of the graft options was performed and compared with the native ACL. Thirty-eight patients with acute ACL ruptures and grade III MCL injuries were treated with ACL reconstruction with a doubled autologous PLT or quadrupled autologous HT. Knee stability and function was evaluated clinically with the Lachman test and KT-2000 arthometer as well as subjectively with functional scores. Effects on the donor ankle were evaluated by biomechanical testing. The ultimate tensile strengths of doubled PLT and quadrupled HT were significantly higher than that of the native ACL and the ultimate tensile strength of doubled PLT was comparable with that of quadrupled HT. There were no significant differences in clinical or functional scores between the two groups. There were no significant differences in pre- and postoperative biomechanical testing of the donor ankle. PLT is a suitable alternative autograft for an ACL reconstruction in patients with a concomitant grade III MCL injury without a significant biomechanical disadvantage to the ankle donor site.

[DORSALIS PEDIS FLAP SERIES-PARALLEL BIG TOE NAIL COMPOSITE TISSUE FLAP TO REPAIR HAND SKIN OF DEGLOVING INJURY WITH THUMB DEFECT].

OBJECTIVE: To investigate the effectiveness of dorsalis pedis flap series-parallel big toe nail composite tissue flap in the repairment of hand skin of degloving injury with tumb defect. METHODS: Between March 2009 and June 2013, 8 cases of hand degloving injury with thumb defect caused by machine twisting were treated. There were 7 males and 1 female with the mean age of 36 years (range, 26-48 years). Injury located at the left hand in 3 cases and at the right hand in 5 cases. The time from injury to hospitalization was 1.5-4.0 hours (mean, 2.5 hours). The defect area was 8 cm x 6 cm to 15 cm x 1 cm. The thumb defect was rated as degree I in 5 cases and as degree II in 3 cases. The contralateral dorsal skin flap (9 cm x 7 cm to 10 cm x 8 cm) combined with ipsilateral big toe nail composite tissue flap (2.5 cm x 1.8 cm to 3.0 cm x 2.0 cm) was used, including 3 parallel anastomosis flaps and 5 series anastomosis flaps. The donor site of the dorsal flap was repaired with thick skin grafts, the stumps wound was covered with tongue flap at the shank side of big toe. RESULTS: Vascular crisis occurred in 1 big toe nail composite tissue flap, margin necrosis occurred in 2 dorsalis pedis flap; the other flaps survived, and primary healing of wound was obtained. The grafted skin at dorsal donor site all survived, skin of hallux toe stump had no necrosis. Eight cases were followed up 4-20 months (mean, 15.5 months). All flaps had soft texture and satisfactory appearance; the cutaneous sensory recovery time was 4-7 months (mean, 5 months). At 4 months after operation, the two-point discrimination of the thumb pulp was 8-10 mm (mean, 9 mm), and the two-point discrimination of dorsal skin flap was 7-9 mm (mean, 8.5 mm). According to Society of Hand Surgery standard for the evaluation of upper part of the function, the results were excellent in 4 cases, good in 3 cases, and fair in 1 case. The donor foot had normal function. CONCLUSION: Dorsalis pedis flap series-parallel big toe nail composite tissue flap is an ideal way to repair hand skin defect, and reconstructs the thumb, which has many advantages, including simple surgical procedure, no limitation to recipient site, soft texture, satisfactory appearance and function of reconstructing thumb, and small donor foot loss.

[Clinical research of ulnar styloid fracture complicated with wrist dorsal branch of ulnar nerve injury].

OBJECTIVE: To analyze the therapy and effectiveness of ulnar styloid fracture complicated with wrist dorsal branch of ulnar nerve injury. METHODS: Between October 2005 and October 2012, 16 cases of ulnar styloid fracture complicated with wrist dorsal branch of ulnar nerve injury were treated. There were 14 males and 2 females with an average age of 42 years (range, 22-58 years). Fracture was caused by traffic accident in 8 cases, by mechanical crush in 5 cases, and by falling in 3 cases. According to the anatomical features of the ulnar styloid and imaging findings, ulnar styloid fractures were classified as type I (ulnar styloid tip fracture) in 1 case and type II (ulnar styloid base fracture) in 15 cases. The skin sensation of ulnar wrist was S0 in 5 cases, S1 in 1 case, S2 in 7 cases, and S3 in 3 cases according to the criteria of the British Medical Research Council in 1954 for the sensory functions of the ulnar wrist. The time from injury to operation was 6-72 hours (mean, 18 hours). Fracture was treated by operative fixation, and nerve was repaired by epineurium neurolysis in 13 cases of nerve contusion and by sural nerve graft in 3 cases of complete nerve rupture. RESULTS: All incisions healed by first intention. Sixteen patients were followed up for an average time of 14 months (range, 6-24 months). The X-ray films showed that all of them achieved bone union at 4-10 weeks after operation (mean, 6 weeks). No patient had complications such as ulnar wrist chronic pain and an inability to rotate. According to Green-O'Brien wrist scoring system, the results were excellent in 13 cases and good in 3 cases; according to the criteria of the British Medical Research Council in 1954 for the sensory functions of the ulnar wrist, the results were excellent in all cases, including 11 cases of S4 and 5 cases of S3+. Two-point discrimination of the ulnar wrist was 5-9 mm (mean, 6.6 mm). CONCLUSION: For patients with ulnar styloid fracture complicated with wrist dorsal branch of ulnar nerve injury, internal fixation and nerve repair should be performed. It can prevent ulnar wrist pain and promote sensory recovery.

[Microsurgical treatment of arterial occlusion in lower extremity].

OBJECTIVE: To investigate the procedure and clinical effect of revascularization for arterial occlusion in lower extremity. METHODS: From July 1998 to March 2005, 29 cases of arterial occlusion were treated by microsurgery. Of 29 cases, there 22 males and 7 females, aging 22-86 years, including 9 cases of thromboangiitis obliterans (TAO), 17 cases of arterial sclerosis obstruction (ASO) and 3 cases of diabetic foot (DF). The location was the left in 17 cases, the right in 11 cases and both sides in 1 case. All cases were inspected by color-Doppler ultrasonic scanning before operation. The cases of ASO and DF were checked with MRA. The results of examinations showed that the locations of arteriostenosis and obstruction were: in 9 cases of TAO, the distal superficial femoral artery in 3 cases, popliteal artery in 5 cases, bilateral dorsal metatarsal artery in 1 case; in 17 cases of ASO, common iliac artery in 2 cases, external iliac artery in 4 cases, femoral artery in 10 cases and popliteal artery in 1 case; and were all superficial femoral artery in 3 cases of DF. DSA examination confirmed that there was appropriate outflow in 15 cases. Basing on the location and extent of the arterial occlusion, 11 cases were treated by the primary deep vein arterializing, 16 cases by arterial bypass distribution and 2 cases of extensive common iliac arterial occlusion were amputated in the level of 1/3 distal thigh. RESULTS: The postoperative duration of follow-up for all cases was 3 months to 7 years. In 9 cases of TAO, 2 healed by first intention after deterioration, 4 healed after changing dressing and 3 had fresh soft tissue growth after debrided superficial secondary necrosis. In 17 cases of ASO, 13 healed by first intention, 2 healed after changing dressing and 2 were amputated. In 3 cases of DF, 2 healed after changed dressing and debrided, 1 was aggravated with the second toe necrosis. CONCLUSION: Performing primary deep vein-arterialization and arterial bypass distribution is effective for treatment of arterial occlusion of lower extremity. The arterial reconstructive patency rate can be improved by microsurgical treatment.