ABSTRACT
A series of degradable, water-swellable PEGs are prepared using crosslinking between primary amines of N,N',Nâ³-tris(2-aminoethyl)phosphoric triamide (TAEPT) and diglycidyl ether of epichlorohydrin-modified PEGs (EMPs). In the crosslinking process, the glycidyl ether is mainly consumed by the -NH2 of TAEPT and the hydroxyl generated from the opened glycidyl ethers (C-OH), producing degradable phosphonyl-amide frameworks as crosslinked points, and ether bonds as short branches, respectively. Studies on anticancer drug entrapment, chemoimmunotherapy agent delivery, degradation, and biological cytotoxicity in vitro suggest that the generated hydrogels have great potential as biomaterials in biomedical applications.
Subject(s)
Antibiotics, Antineoplastic/pharmacology , Carcinoma/drug therapy , Colonic Neoplasms/drug therapy , Doxorubicin/pharmacology , Hydrogels/chemical synthesis , Polyethylene Glycols/chemistry , Animals , Antibiotics, Antineoplastic/chemistry , Carcinoma/pathology , Cell Survival/drug effects , Colonic Neoplasms/pathology , Cross-Linking Reagents/chemistry , Doxorubicin/chemistry , Drug Carriers , Drug Compounding , Epichlorohydrin/chemistry , Epoxy Compounds/chemistry , Female , HEK293 Cells , Humans , Hydrogels/pharmacology , Mice , Mice, Inbred BALB C , Organophosphorus Compounds/chemistry , Xenograft Model Antitumor AssaysABSTRACT
This paper reviews the recent research and development of hyperbranched polymers (HPs) and dendrimers, and their use as templates for organic-inorganic hybrid nanomaterials. Hyperbranched polymers (HPs) are highly branched macromolecules with three-dimensional globular structures featuring unique properties such as low viscosity, high solubility, and a large number of terminal functional groups compared to their linear analogs. They are easily prepared by (1) condensation polymerization, (2) self-condensing vinyl copolymerization (SCVCP), and (3) ring-opening multibranch polymerization methods. Organic-inorganic hybrid nanomaterials are synthesized by a template approach using HPs/dendrimers. Monometallic, bimetallic (alloy and core/shell), semiconductor, and metal oxide nanoparticles have been prepared by this route. The dendrimer component of these composites serves not only as a template for preparing the nanoparticles but also as a stabilizer for the nanoparticles.
Subject(s)
Dendrimers/chemistry , Inorganic Chemicals/chemistry , Molecular Imprinting/methods , Nanostructures/chemistry , Nanostructures/ultrastructure , Organic Chemicals/chemistry , Polymers/chemistry , Macromolecular Substances/chemistry , Molecular Conformation , Surface PropertiesABSTRACT
A series of oleamide derivatives, (C(18)H(34)NO)(2)(CH(2))(n) [n = 2 (1a), 3 (1b), 4 (1c), or 6 (1d); C(18)H(34)NO = oleic amide fragment] and (C(18)H(34)NO)(CH(2))(6)NH(2) (2), have been synthesized and their self-assembly is investigated in ethanol/water media. Self-assembly of 1a and 1b in ethanol/water (1/0.1 v/v) solution (5 mg mL(-1)) yields microspheres (MSs) with the average diameter â¼10 µm via a gradual temperature reduction and solvent volatilization process. Under the same self-assembly conditions, microrods (average diameter â¼6 µm and several tens of micrometers in length), micronecklace-like, and shape-irregular microparticles are formed from the self-assembly of 1c, 1d, and 2, respectively. The kinetics of evolution for their self-assemblies by dynamic light scattering technique and in situ observation by optical microscopy reveals that the microstructures formation is from a well-behaved aggregation of nanoscale micelles induced by solvent volatilization. The FT-IR and temperature-dependent (1)H-NMR spectra demonstrate the hydrogen bonding force and π-π stacking, which drove the self-assembly of all oleamide derivatives in ethanol/water. Among the fabricated microstructures, the MSs from 1a exhibit the best dispersity, which thus have been used as a scaffold for the in vitro release of doxorubicin. The results demonstrate a pH-sensitive release process, enhanced release specifically at low pH 5.2.