Subject(s)
Macular Degeneration , Retinal Artery Occlusion , Retinal Diseases , Acute Disease , Angiography , Fluorescein Angiography , Humans , Ischemia/complications , Ischemia/diagnosis , Retinal Artery Occlusion/complications , Retinal Artery Occlusion/diagnosis , Retinal Diseases/diagnosis , Retinal Diseases/diagnostic imaging , Retinal Vessels/diagnostic imaging , Tomography, Optical CoherenceSubject(s)
Corneal Ulcer , Adolescent , Adult , Aged , Aged, 80 and over , Child , Cohort Studies , Corneal Ulcer/diagnosis , Corneal Ulcer/epidemiology , Corneal Ulcer/etiology , Corneal Ulcer/therapy , Delayed Diagnosis/statistics & numerical data , Eye Infections, Bacterial/diagnosis , Eye Infections, Bacterial/epidemiology , Eye Infections, Bacterial/microbiology , Eye Infections, Bacterial/therapy , Eye Infections, Fungal/diagnosis , Eye Infections, Fungal/epidemiology , Eye Infections, Fungal/microbiology , Eye Infections, Fungal/therapy , Eye Infections, Parasitic/diagnosis , Eye Infections, Parasitic/epidemiology , Eye Infections, Parasitic/parasitology , Eye Infections, Parasitic/therapy , Female , Hospitalization/statistics & numerical data , Humans , Male , Middle Aged , Prognosis , Retrospective Studies , Risk Factors , Severity of Illness Index , Young AdultSubject(s)
Behcet Syndrome/diagnosis , Retinal Artery Occlusion/diagnosis , Retinal Vein Occlusion/diagnosis , Adult , Behcet Syndrome/complications , Diagnosis, Differential , Female , Fluorescein Angiography , Fundus Oculi , Humans , Multimodal Imaging , Retinal Artery Occlusion/etiology , Retinal Vein Occlusion/etiology , Tomography, Optical CoherenceSubject(s)
Central Nervous System Fungal Infections , Eye Infections, Fungal , Mucormycosis/diagnosis , Mucormycosis/surgery , Orbital Diseases , Rhinitis , Aged , Central Nervous System Fungal Infections/complications , Central Nervous System Fungal Infections/diagnosis , Central Nervous System Fungal Infections/pathology , Central Nervous System Fungal Infections/surgery , Diabetes Complications/diagnosis , Diabetes Complications/microbiology , Diabetes Complications/surgery , Emergency Medical Services/methods , Eye Infections, Fungal/diagnosis , Eye Infections, Fungal/pathology , Eye Infections, Fungal/surgery , Fatal Outcome , Female , Humans , Invasive Fungal Infections/diagnosis , Invasive Fungal Infections/microbiology , Invasive Fungal Infections/surgery , Male , Middle Aged , Mucormycosis/pathology , Orbital Diseases/diagnosis , Orbital Diseases/microbiology , Orbital Diseases/pathology , Orbital Diseases/surgery , Rhinitis/diagnosis , Rhinitis/microbiology , Rhinitis/pathology , Rhinitis/surgerySubject(s)
Contact Lenses , Retinal Degeneration/diagnosis , Retinal Degeneration/therapy , Cornea/pathology , Corneal Topography , Humans , Male , Middle Aged , Myopia/complications , Myopia/diagnosis , Myopia/pathology , Myopia/therapy , Retinal Degeneration/complications , Retinal Degeneration/pathology , Sclera/pathology , Severity of Illness Index , Slit Lamp Microscopy , Vision Disorders/diagnosis , Vision Disorders/etiology , Vision Disorders/therapySubject(s)
Acanthamoeba Keratitis/diagnosis , Candidiasis/diagnosis , Contact Lenses/adverse effects , Contact Lenses/microbiology , Eye Infections, Fungal/diagnosis , Keratitis/microbiology , Acanthamoeba/isolation & purification , Acanthamoeba Keratitis/complications , Acanthamoeba Keratitis/drug therapy , Administration, Topical , Anti-Bacterial Agents/administration & dosage , Candida albicans/isolation & purification , Candidiasis/complications , Candidiasis/drug therapy , Coinfection/diagnosis , Coinfection/drug therapy , Coinfection/microbiology , Eye Infections, Fungal/complications , Eye Infections, Fungal/drug therapy , Humans , Keratitis/diagnosis , Keratitis/drug therapy , Male , Young AdultABSTRACT
PURPOSE: Prospective randomised study to compare the impact of phacoemusification (PHACO) and small incision cataract surgery (SICS) on endothelial structure (cell density and morphology) and refractive results (visual acuity, induced astigmatism). METHODS: Prospective study of 57 patients (63 eyes) over 20 months (May 2012-January 2014) undergoing surgery by 2 experienced surgeons. We included patients with senile or presenile cataracts, LOCS III class 2, 3 and 4. Patients were randomized into 2 groups based on their birth month (group 1: PHACO [33]; group 2: SICS [30]). All pre- intra- and postoperative data were collected prospectively. The minimum follow-up was 6 months. We used the SPSS 18.0 for statistical analysis. Statistical tests used included the test-t Student, the Anova test, the Mann-Witney non-parametric test and the Khi2 test. A threshold of significance was set at 0.05. RESULTS: The mean preoperative endothelial cell density was 2447.5±225 c/mm2 with no significant difference between the two groups (P=0.207). The mean percentage of hexagonality was 55.5±8.2% in groups 1 and 2. The most significant cell loss was during the first immediate postoperative period for both groups. At Day 15 postoperative, the decrease in cell loss was significant (P<0.001) with a mean loss of 312.9±208.9 c/mm2 (P<10-2). Postoperatively, the mean best-corrected visual acuity was 0.057 log MAR for all of our patients (P=0.170); no patient had an acuity ≤1/10. The mean astigmatism at the conclusion of follow-up was 1.08±0.42 D in group 1 and 1.51±0.55 D in group 2, with a significant difference (P=0.001). CONCLUSION: Both SICS and PHACO give excellent results, both anatomical and refractive. However, SICS appears to be more advantageous than PHACO in terms of speed, cost, and independence from technology, and appears to be better suited to dense cataracts and mass surgery.
Subject(s)
Cataract Extraction/methods , Cataract/therapy , Microsurgery/methods , Phacoemulsification/methods , Aged , Aged, 80 and over , Cataract/pathology , Cataract Extraction/adverse effects , Female , Humans , Intraoperative Complications/etiology , Male , Microsurgery/adverse effects , Middle Aged , Phacoemulsification/adverse effects , Postoperative Complications/etiology , Postoperative Period , Visual AcuityABSTRACT
A pterygium is characterized by abnormal fibrovascular corneoconjunctival tissue. A number of investigations have attempted to elucidate this incompletely understood pathology. Since vascular endothelial growth factor (VEGF) and p53 are known to participate in tumor vascularization, our purpose was to study VEGF and p53 expression in active primary and recurrent pterygium from Tunisian patients. To this end, 15 cases of active primary pterygium and five cases of recurrent pterygium from Tunisia were studied by immunohistochemistry. Antibodies raised against VEGF and p53 were used to analyze the distribution and expression of these markers in pterygium and normal human conjunctiva were used as negative control. VEGF and p53 proteins were found in all cases of primary pterygium in epithelial, fibroblast and vascular endothelial cells. Active primary and recurrent pterygium have different patterns of expression. In primary pterygium, an important variability of p53 and VEGF expression was observed. However, in recurrent pterygium, p53 immunoreactivity was weak to moderate, whereas VEGF immunoreactivity was strong. In normal human conjunctiva, VEGF and p53 expression was weak to negative. The overexpression of VEGF in active primary and recurrent pterygium suggests that angiogenesis may play a role in pterygium pathogenesis and the expression of p53 in active primary pterygium, which might be associated with its mutated form, supports the hypothesis that actinic radiation may be involved in the genesis of pterygium. Thus, VEGF and p53 may be useful biomarkers for understanding the physiopathology of pterygium.
Subject(s)
Corneal Neovascularization/genetics , Pterygium/metabolism , Vascular Endothelial Growth Factor A/biosynthesis , Adult , Aged , Conjunctiva/metabolism , Female , Genes, p53 , Humans , Immunoenzyme Techniques , Male , Middle Aged , Pterygium/epidemiology , Pterygium/genetics , Recurrence , Tumor Suppressor Protein p53/biosynthesis , Tunisia/epidemiology , Vascular Endothelial Growth Factor A/genetics , Young AdultABSTRACT
PURPOSE: Diabetic fibrovascular membranes are the main pathological changes of proliferative diabetic retinopathy that can cause serious complications leading to blindness. Since the mechanism of fibrovascular membrane development is still unknown, the aim of our study was to identify potential biomarkers for this pathology. To this end, we analyzed the simultaneous expression of ICAM-1, VCAM-1 and VEGF within tissues of diabetic fibrovascular membranes. PATIENTS AND METHODS: Fibrovascular membranes were taken from nine diabetic patients with proliferative diabetic retinopathy. The fibrovascular membrane specimens were analyzed by immunohistochemistry to determine ICAM-1, VCAM-1 and VEGF expression. Controls were collected on nine normal conjunctivas removed during senile cataract surgery. RESULTS: Coexpression of ICAM-1, VCAM-1 and VEGF was found in most of the diabetic fibrovascular membranes studied. Thus, ICAM-1 was positive in eight of nine membranes (82%), VCAM-1 in seven of nine membranes (78%) and VEGF in all the membranes. CONCLUSIONS: The substantial overexpression of adhesion molecules ICAM-1, VCAM-1 and of VEGF suggests that these molecules might contribute to the development of fibrovascular membranes in patients with proliferative diabetic retinopathy, and that they could constitute suitable markers of this pathology.
Subject(s)
Diabetic Retinopathy/pathology , Intercellular Adhesion Molecule-1/analysis , Retinal Vessels/pathology , Vascular Cell Adhesion Molecule-1/analysis , Vascular Endothelial Growth Factor A/analysis , Adult , Aged , Aging , Biopsy , Cataract Extraction , Cell Adhesion Molecules/analysis , Conjunctiva/pathology , Disease Progression , Female , Humans , Immunohistochemistry/methods , Intercellular Adhesion Molecule-1/genetics , Male , Middle Aged , Reference Values , Vascular Cell Adhesion Molecule-1/genetics , Vascular Endothelial Growth Factor A/genetics , Young AdultABSTRACT
PURPOSE: To evaluate the frequency, characteristics, causes, and risk factors of late recurrent retinal detachments (LRRD). METHODS: The authors retrospectively analyzed 445 eyes operated consecutively for rhegmatogenous retinal detachment between 1990 and 2003 by the same surgeon. Only eyes with complete reattachment after a minimum follow-up of 6 months were included. The authors defined LRRD as detachment occurring at least 6 months after a complete retinal reattachment. RESULTS: Nine eyes had a LRRD (2.02%). Mean age was 52.55 years. Six eyes had scleral buckle procedure and three eyes had vitrectomy silicone oil injection then silicone oil removal. LRRD occurred after an average period of 54 months. During follow-up two patients had a removal of extrusion of scleral buckling material. New or reopened breaks were associated with LRRD in all eyes. Endo-ocular surgery was carried out in seven eyes. The retinal reattachment was achieved in the seven eyes. Final visual acuity ranged from 20/400 to 20/60 after an average follow-up of 37.8 months. Relation between aphakic eyes (and more generally nonphakic eyes) and LRRD was close to significant value (p=0.05). LRRD was statistically independent (p>0.05) of myopia, preoperative pseudophakia, vitrectomy for initial detachment, scleral buckle removal, and cataract surgery after reattachment. CONCLUSIONS: LRRD were rare. Most of them were due to a retinal break. This break can be a new break, or reopened break especially after removal of scleral buckle material. Vitreous traction, at the vitreous base, seemed to be the cause of these breaks.
